Oxidative stress in dogs with multicentric lymphoma: Effect of chemotherapy on oxidative and antioxidant biomarkers
Introduction: Lymphoma is one of the most common types of cancer in dogs, characterized by the proliferation of lymphoid cells. The treatment of this type of cancer is usually based on drugs with high toxicity, which can cause severe side effects. Objectives: Therefore, the aim of this study was to...
Gespeichert in:
| Veröffentlicht in: | Redox report : communications in free radical research 2015-11, Vol.20 (6), p.267-274 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 274 |
|---|---|
| container_issue | 6 |
| container_start_page | 267 |
| container_title | Redox report : communications in free radical research |
| container_volume | 20 |
| creator | Bottari, Nathieli B. Munhoz, Thiago D. Torbitz, Vanessa D. Tonin, Alexandre A. Anai, Letícia A. Semolin, Lívia M. S. Jark, Paulo C. Bollick, Yãnaí S. Moresco, Rafael N. França, Raqueli T. Lopes, Sonia T. A. Stefani, Lenita M. Tinucci-Costa, Mirela Silva, Aleksandro S. Da |
| description | Introduction: Lymphoma is one of the most common types of cancer in dogs, characterized by the proliferation of lymphoid cells. The treatment of this type of cancer is usually based on drugs with high toxicity, which can cause severe side effects.
Objectives: Therefore, the aim of this study was to measure the levels of advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances (TBARS), and ferric reducing antioxidant power (FRAP) in dogs with multicentric lymphoma before and after chemotherapy.
Methods: For this purpose, serum samples of 25 dogs diagnosed with multicentric lymphoma and 15 healthy dogs were used. The animals were exposed to CHOP chemotherapy (cyclophosphamide, vincristine, doxorubicin, and prednisone) and serum samples were collected 5 weeks after treatment.
Results: High levels of TBARS, AOPP, and FRAP were observed in sera of dogs with multicentric lymphoma when compared to healthy dogs (P 0.05). Exacerbated oxidative stress was observed in dogs with multicentric lymphoma Group II (Stage IV-V: involvement of lymph nodes and organs ) compared to those in Group I (Stage I-III: only affected lymph nodes) of the disease, as well as the dogs with clinical signs and T immunophenotype. Another important result was observed after chemotherapy, where FRAP levels were higher in dogs that showed complete disease remission compared to animals with progressive disease.
Conclusions: Therefore, dogs with lymphoma showed protein oxidation and lipid peroxidation, as well as increased total antioxidants before and after chemotherapy compared to the control group. |
| doi_str_mv | 10.1179/1351000215Y.0000000037 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6837369</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>26274787</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-195d427c9bab83ebdbf6e235c3246bb7efeca7bef5dbac56576bb5377449a9ed3</originalsourceid><addsrcrecordid>eNqFUclOwzAUtBAIyvILyD8QiO0kTjggIcQmVeoFDpwsr40hiSvbBfr3uAulnLBk2XpvZt4yAJyj_AIh2lwiUqI8zzEqXy_yzSF0D4wQLUiGG1zvp38CZUvUETgO4W0JqZr6EBzhCtOC1nQEwuTLKh7th4Yheh0CtANUbhrgp40t7OddtFIP0VsJu0U_a13Pr-CdMVpG6AyUre5dbLXnswV0A3RbOT6odKNdRYYIhU1U_659OAUHhndBn23eE_Byf_d8-5iNJw9PtzfjTBYUxww1pSowlY3goiZaKGEqjUkpCS4qIahOPXAqtCmV4LKsSpqiJaG0KBreaEVOwPVadzYXvVarMXjHZt6mRhbMccv-Zgbbsqn7YFVNaNpUEqjWAtK7ELw2Wy7K2dIGtmMD-7UhEc93K29pP3tPgJs1wA7G-Z5_Ot8pFvmic954PkgbGPmnyDeXD5y2</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Oxidative stress in dogs with multicentric lymphoma: Effect of chemotherapy on oxidative and antioxidant biomarkers</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Bottari, Nathieli B. ; Munhoz, Thiago D. ; Torbitz, Vanessa D. ; Tonin, Alexandre A. ; Anai, Letícia A. ; Semolin, Lívia M. S. ; Jark, Paulo C. ; Bollick, Yãnaí S. ; Moresco, Rafael N. ; França, Raqueli T. ; Lopes, Sonia T. A. ; Stefani, Lenita M. ; Tinucci-Costa, Mirela ; Silva, Aleksandro S. Da</creator><creatorcontrib>Bottari, Nathieli B. ; Munhoz, Thiago D. ; Torbitz, Vanessa D. ; Tonin, Alexandre A. ; Anai, Letícia A. ; Semolin, Lívia M. S. ; Jark, Paulo C. ; Bollick, Yãnaí S. ; Moresco, Rafael N. ; França, Raqueli T. ; Lopes, Sonia T. A. ; Stefani, Lenita M. ; Tinucci-Costa, Mirela ; Silva, Aleksandro S. Da</creatorcontrib><description>Introduction: Lymphoma is one of the most common types of cancer in dogs, characterized by the proliferation of lymphoid cells. The treatment of this type of cancer is usually based on drugs with high toxicity, which can cause severe side effects.
Objectives: Therefore, the aim of this study was to measure the levels of advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances (TBARS), and ferric reducing antioxidant power (FRAP) in dogs with multicentric lymphoma before and after chemotherapy.
Methods: For this purpose, serum samples of 25 dogs diagnosed with multicentric lymphoma and 15 healthy dogs were used. The animals were exposed to CHOP chemotherapy (cyclophosphamide, vincristine, doxorubicin, and prednisone) and serum samples were collected 5 weeks after treatment.
Results: High levels of TBARS, AOPP, and FRAP were observed in sera of dogs with multicentric lymphoma when compared to healthy dogs (P < 0.01), and even higher levels (TBARS and AOPP) were found after chemotherapy i.e. treatment exacerbated the oxidative stress levels. On the other hand, FRAP levels did not differ statistically between animals with lymphoma before and after treatment (P > 0.05). Exacerbated oxidative stress was observed in dogs with multicentric lymphoma Group II (Stage IV-V: involvement of lymph nodes and organs ) compared to those in Group I (Stage I-III: only affected lymph nodes) of the disease, as well as the dogs with clinical signs and T immunophenotype. Another important result was observed after chemotherapy, where FRAP levels were higher in dogs that showed complete disease remission compared to animals with progressive disease.
Conclusions: Therefore, dogs with lymphoma showed protein oxidation and lipid peroxidation, as well as increased total antioxidants before and after chemotherapy compared to the control group.</description><identifier>ISSN: 1351-0002</identifier><identifier>EISSN: 1743-2928</identifier><identifier>DOI: 10.1179/1351000215Y.0000000037</identifier><identifier>PMID: 26274787</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; Antineoplastic Agents - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antioxidants ; Antioxidants - metabolism ; Biomarkers, Tumor - metabolism ; Cancer ; Cell Proliferation ; Cyclophosphamide - adverse effects ; Disease Progression ; Dog ; Dogs ; Doxorubicin - adverse effects ; Female ; Immunohistochemistry ; Immunophenotyping ; Lipid Peroxidation ; Lymphoma ; Lymphoma - blood ; Lymphoma - drug therapy ; Male ; Oxidant ; Oxidative Stress ; Oxygen - metabolism ; Prednisolone - adverse effects ; Reactive Oxygen Species - metabolism ; Remission Induction ; Thiobarbituric Acid Reactive Substances - metabolism ; Vincristine - adverse effects</subject><ispartof>Redox report : communications in free radical research, 2015-11, Vol.20 (6), p.267-274</ispartof><rights>W. S. Maney & Son Ltd 2015 2015</rights><rights>W. S. Maney & Son Ltd 2015 2015 W. S. Maney & Son Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-195d427c9bab83ebdbf6e235c3246bb7efeca7bef5dbac56576bb5377449a9ed3</citedby><cites>FETCH-LOGICAL-c472t-195d427c9bab83ebdbf6e235c3246bb7efeca7bef5dbac56576bb5377449a9ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837369/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837369/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26274787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bottari, Nathieli B.</creatorcontrib><creatorcontrib>Munhoz, Thiago D.</creatorcontrib><creatorcontrib>Torbitz, Vanessa D.</creatorcontrib><creatorcontrib>Tonin, Alexandre A.</creatorcontrib><creatorcontrib>Anai, Letícia A.</creatorcontrib><creatorcontrib>Semolin, Lívia M. S.</creatorcontrib><creatorcontrib>Jark, Paulo C.</creatorcontrib><creatorcontrib>Bollick, Yãnaí S.</creatorcontrib><creatorcontrib>Moresco, Rafael N.</creatorcontrib><creatorcontrib>França, Raqueli T.</creatorcontrib><creatorcontrib>Lopes, Sonia T. A.</creatorcontrib><creatorcontrib>Stefani, Lenita M.</creatorcontrib><creatorcontrib>Tinucci-Costa, Mirela</creatorcontrib><creatorcontrib>Silva, Aleksandro S. Da</creatorcontrib><title>Oxidative stress in dogs with multicentric lymphoma: Effect of chemotherapy on oxidative and antioxidant biomarkers</title><title>Redox report : communications in free radical research</title><addtitle>Redox Rep</addtitle><description>Introduction: Lymphoma is one of the most common types of cancer in dogs, characterized by the proliferation of lymphoid cells. The treatment of this type of cancer is usually based on drugs with high toxicity, which can cause severe side effects.
Objectives: Therefore, the aim of this study was to measure the levels of advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances (TBARS), and ferric reducing antioxidant power (FRAP) in dogs with multicentric lymphoma before and after chemotherapy.
Methods: For this purpose, serum samples of 25 dogs diagnosed with multicentric lymphoma and 15 healthy dogs were used. The animals were exposed to CHOP chemotherapy (cyclophosphamide, vincristine, doxorubicin, and prednisone) and serum samples were collected 5 weeks after treatment.
Results: High levels of TBARS, AOPP, and FRAP were observed in sera of dogs with multicentric lymphoma when compared to healthy dogs (P < 0.01), and even higher levels (TBARS and AOPP) were found after chemotherapy i.e. treatment exacerbated the oxidative stress levels. On the other hand, FRAP levels did not differ statistically between animals with lymphoma before and after treatment (P > 0.05). Exacerbated oxidative stress was observed in dogs with multicentric lymphoma Group II (Stage IV-V: involvement of lymph nodes and organs ) compared to those in Group I (Stage I-III: only affected lymph nodes) of the disease, as well as the dogs with clinical signs and T immunophenotype. Another important result was observed after chemotherapy, where FRAP levels were higher in dogs that showed complete disease remission compared to animals with progressive disease.
Conclusions: Therefore, dogs with lymphoma showed protein oxidation and lipid peroxidation, as well as increased total antioxidants before and after chemotherapy compared to the control group.</description><subject>Animals</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Cell Proliferation</subject><subject>Cyclophosphamide - adverse effects</subject><subject>Disease Progression</subject><subject>Dog</subject><subject>Dogs</subject><subject>Doxorubicin - adverse effects</subject><subject>Female</subject><subject>Immunohistochemistry</subject><subject>Immunophenotyping</subject><subject>Lipid Peroxidation</subject><subject>Lymphoma</subject><subject>Lymphoma - blood</subject><subject>Lymphoma - drug therapy</subject><subject>Male</subject><subject>Oxidant</subject><subject>Oxidative Stress</subject><subject>Oxygen - metabolism</subject><subject>Prednisolone - adverse effects</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Remission Induction</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Vincristine - adverse effects</subject><issn>1351-0002</issn><issn>1743-2928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUclOwzAUtBAIyvILyD8QiO0kTjggIcQmVeoFDpwsr40hiSvbBfr3uAulnLBk2XpvZt4yAJyj_AIh2lwiUqI8zzEqXy_yzSF0D4wQLUiGG1zvp38CZUvUETgO4W0JqZr6EBzhCtOC1nQEwuTLKh7th4Yheh0CtANUbhrgp40t7OddtFIP0VsJu0U_a13Pr-CdMVpG6AyUre5dbLXnswV0A3RbOT6odKNdRYYIhU1U_659OAUHhndBn23eE_Byf_d8-5iNJw9PtzfjTBYUxww1pSowlY3goiZaKGEqjUkpCS4qIahOPXAqtCmV4LKsSpqiJaG0KBreaEVOwPVadzYXvVarMXjHZt6mRhbMccv-Zgbbsqn7YFVNaNpUEqjWAtK7ELw2Wy7K2dIGtmMD-7UhEc93K29pP3tPgJs1wA7G-Z5_Ot8pFvmic954PkgbGPmnyDeXD5y2</recordid><startdate>20151102</startdate><enddate>20151102</enddate><creator>Bottari, Nathieli B.</creator><creator>Munhoz, Thiago D.</creator><creator>Torbitz, Vanessa D.</creator><creator>Tonin, Alexandre A.</creator><creator>Anai, Letícia A.</creator><creator>Semolin, Lívia M. S.</creator><creator>Jark, Paulo C.</creator><creator>Bollick, Yãnaí S.</creator><creator>Moresco, Rafael N.</creator><creator>França, Raqueli T.</creator><creator>Lopes, Sonia T. A.</creator><creator>Stefani, Lenita M.</creator><creator>Tinucci-Costa, Mirela</creator><creator>Silva, Aleksandro S. Da</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20151102</creationdate><title>Oxidative stress in dogs with multicentric lymphoma: Effect of chemotherapy on oxidative and antioxidant biomarkers</title><author>Bottari, Nathieli B. ; Munhoz, Thiago D. ; Torbitz, Vanessa D. ; Tonin, Alexandre A. ; Anai, Letícia A. ; Semolin, Lívia M. S. ; Jark, Paulo C. ; Bollick, Yãnaí S. ; Moresco, Rafael N. ; França, Raqueli T. ; Lopes, Sonia T. A. ; Stefani, Lenita M. ; Tinucci-Costa, Mirela ; Silva, Aleksandro S. Da</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-195d427c9bab83ebdbf6e235c3246bb7efeca7bef5dbac56576bb5377449a9ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Cell Proliferation</topic><topic>Cyclophosphamide - adverse effects</topic><topic>Disease Progression</topic><topic>Dog</topic><topic>Dogs</topic><topic>Doxorubicin - adverse effects</topic><topic>Female</topic><topic>Immunohistochemistry</topic><topic>Immunophenotyping</topic><topic>Lipid Peroxidation</topic><topic>Lymphoma</topic><topic>Lymphoma - blood</topic><topic>Lymphoma - drug therapy</topic><topic>Male</topic><topic>Oxidant</topic><topic>Oxidative Stress</topic><topic>Oxygen - metabolism</topic><topic>Prednisolone - adverse effects</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Remission Induction</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Vincristine - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bottari, Nathieli B.</creatorcontrib><creatorcontrib>Munhoz, Thiago D.</creatorcontrib><creatorcontrib>Torbitz, Vanessa D.</creatorcontrib><creatorcontrib>Tonin, Alexandre A.</creatorcontrib><creatorcontrib>Anai, Letícia A.</creatorcontrib><creatorcontrib>Semolin, Lívia M. S.</creatorcontrib><creatorcontrib>Jark, Paulo C.</creatorcontrib><creatorcontrib>Bollick, Yãnaí S.</creatorcontrib><creatorcontrib>Moresco, Rafael N.</creatorcontrib><creatorcontrib>França, Raqueli T.</creatorcontrib><creatorcontrib>Lopes, Sonia T. A.</creatorcontrib><creatorcontrib>Stefani, Lenita M.</creatorcontrib><creatorcontrib>Tinucci-Costa, Mirela</creatorcontrib><creatorcontrib>Silva, Aleksandro S. Da</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Redox report : communications in free radical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bottari, Nathieli B.</au><au>Munhoz, Thiago D.</au><au>Torbitz, Vanessa D.</au><au>Tonin, Alexandre A.</au><au>Anai, Letícia A.</au><au>Semolin, Lívia M. S.</au><au>Jark, Paulo C.</au><au>Bollick, Yãnaí S.</au><au>Moresco, Rafael N.</au><au>França, Raqueli T.</au><au>Lopes, Sonia T. A.</au><au>Stefani, Lenita M.</au><au>Tinucci-Costa, Mirela</au><au>Silva, Aleksandro S. Da</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative stress in dogs with multicentric lymphoma: Effect of chemotherapy on oxidative and antioxidant biomarkers</atitle><jtitle>Redox report : communications in free radical research</jtitle><addtitle>Redox Rep</addtitle><date>2015-11-02</date><risdate>2015</risdate><volume>20</volume><issue>6</issue><spage>267</spage><epage>274</epage><pages>267-274</pages><issn>1351-0002</issn><eissn>1743-2928</eissn><abstract>Introduction: Lymphoma is one of the most common types of cancer in dogs, characterized by the proliferation of lymphoid cells. The treatment of this type of cancer is usually based on drugs with high toxicity, which can cause severe side effects.
Objectives: Therefore, the aim of this study was to measure the levels of advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances (TBARS), and ferric reducing antioxidant power (FRAP) in dogs with multicentric lymphoma before and after chemotherapy.
Methods: For this purpose, serum samples of 25 dogs diagnosed with multicentric lymphoma and 15 healthy dogs were used. The animals were exposed to CHOP chemotherapy (cyclophosphamide, vincristine, doxorubicin, and prednisone) and serum samples were collected 5 weeks after treatment.
Results: High levels of TBARS, AOPP, and FRAP were observed in sera of dogs with multicentric lymphoma when compared to healthy dogs (P < 0.01), and even higher levels (TBARS and AOPP) were found after chemotherapy i.e. treatment exacerbated the oxidative stress levels. On the other hand, FRAP levels did not differ statistically between animals with lymphoma before and after treatment (P > 0.05). Exacerbated oxidative stress was observed in dogs with multicentric lymphoma Group II (Stage IV-V: involvement of lymph nodes and organs ) compared to those in Group I (Stage I-III: only affected lymph nodes) of the disease, as well as the dogs with clinical signs and T immunophenotype. Another important result was observed after chemotherapy, where FRAP levels were higher in dogs that showed complete disease remission compared to animals with progressive disease.
Conclusions: Therefore, dogs with lymphoma showed protein oxidation and lipid peroxidation, as well as increased total antioxidants before and after chemotherapy compared to the control group.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>26274787</pmid><doi>10.1179/1351000215Y.0000000037</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1351-0002 |
| ispartof | Redox report : communications in free radical research, 2015-11, Vol.20 (6), p.267-274 |
| issn | 1351-0002 1743-2928 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6837369 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antineoplastic Agents - adverse effects Antineoplastic Combined Chemotherapy Protocols - adverse effects Antioxidants Antioxidants - metabolism Biomarkers, Tumor - metabolism Cancer Cell Proliferation Cyclophosphamide - adverse effects Disease Progression Dog Dogs Doxorubicin - adverse effects Female Immunohistochemistry Immunophenotyping Lipid Peroxidation Lymphoma Lymphoma - blood Lymphoma - drug therapy Male Oxidant Oxidative Stress Oxygen - metabolism Prednisolone - adverse effects Reactive Oxygen Species - metabolism Remission Induction Thiobarbituric Acid Reactive Substances - metabolism Vincristine - adverse effects |
| title | Oxidative stress in dogs with multicentric lymphoma: Effect of chemotherapy on oxidative and antioxidant biomarkers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T20%3A17%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oxidative%20stress%20in%20dogs%20with%20multicentric%20lymphoma:%20Effect%20of%20chemotherapy%20on%20oxidative%20and%20antioxidant%20biomarkers&rft.jtitle=Redox%20report%20:%20communications%20in%20free%20radical%20research&rft.au=Bottari,%20Nathieli%20B.&rft.date=2015-11-02&rft.volume=20&rft.issue=6&rft.spage=267&rft.epage=274&rft.pages=267-274&rft.issn=1351-0002&rft.eissn=1743-2928&rft_id=info:doi/10.1179/1351000215Y.0000000037&rft_dat=%3Cpubmed_cross%3E26274787%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/26274787&rfr_iscdi=true |