Dietary Intake of Green Nut Oil or DHA Ameliorates DHA Distribution in the Brain of a Mouse Model of Dementia Accompanied by Memory Recovery
Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has significant healthbenefits. Previous studies reported decreased levels of DHA and DHA-containing phosphatidylcholines inthe brain of animals suffering from Alzheimer's disease, the most common type of dementia; furthermore,D...
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| Veröffentlicht in: | Nutrients 2019-10, Vol.11 (10), p.2371 |
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| creator | Takeyama, Emiko Islam, Ariful Watanabe, Nakamichi Tsubaki, Hiroe Fukushima, Masako Mamun, Md Al Sato, Shumpei Sato, Tomohito Eto, Fumihiro Yao, Ikuko Ito, Takashi K Horikawa, Makoto Setou, Mitsutoshi |
| description | Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has significant healthbenefits. Previous studies reported decreased levels of DHA and DHA-containing phosphatidylcholines inthe brain of animals suffering from Alzheimer's disease, the most common type of dementia; furthermore,DHA supplementation has been found to improve brain DHA levels and memory efficiency in dementia. Oilextracted from the seeds of
(green nut oil; GNO) is also expected to have DHA like effectsas it contains approximately 50% α-linolenic acid, a precursor of DHA. Despite this, changes in the spatialdistribution of DHA in the brain of animals with dementia following GNO or DHA supplementation remainunexplored. In this study, desorption electrospray ionization imaging mass spectrometry (DESI-IMS) wasapplied to observe the effects of GNO or DHA supplementation upon the distribution of DHA in the brain ofmale senescence-accelerated mouse-prone 8 (SAMP8) mice, a mouse model of dementia. DESI-IMS revealedthat brain DHA distribution increased 1.85-fold and 3.67-fold in GNO-fed and DHA-fed SAMP8 mice,respectively, compared to corn oil-fed SAMP8 mice. Memory efficiency in SAMP8 mice was also improvedby GNO or DHA supplementation. In summary, this study suggests the possibility of GNO or DHAsupplementation for the prevention of dementia. |
| doi_str_mv | 10.3390/nu11102371 |
| format | Article |
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(green nut oil; GNO) is also expected to have DHA like effectsas it contains approximately 50% α-linolenic acid, a precursor of DHA. Despite this, changes in the spatialdistribution of DHA in the brain of animals with dementia following GNO or DHA supplementation remainunexplored. In this study, desorption electrospray ionization imaging mass spectrometry (DESI-IMS) wasapplied to observe the effects of GNO or DHA supplementation upon the distribution of DHA in the brain ofmale senescence-accelerated mouse-prone 8 (SAMP8) mice, a mouse model of dementia. DESI-IMS revealedthat brain DHA distribution increased 1.85-fold and 3.67-fold in GNO-fed and DHA-fed SAMP8 mice,respectively, compared to corn oil-fed SAMP8 mice. Memory efficiency in SAMP8 mice was also improvedby GNO or DHA supplementation. In summary, this study suggests the possibility of GNO or DHAsupplementation for the prevention of dementia.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu11102371</identifier><identifier>PMID: 31590339</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>alpha-linolenic acid ; Animal Feed ; animal models ; animal suffering ; Animals ; Apoptosis ; Behavior, Animal ; Blood-brain barrier ; Brain ; Brain - metabolism ; Brain - physiopathology ; Brain research ; corn ; Dementia ; Dementia - metabolism ; Dementia - physiopathology ; Dementia - prevention & control ; Dementia - psychology ; Dementia disorders ; desorption ; Diet ; Dietary intake ; Disease Models, Animal ; docosahexaenoic acid ; Docosahexaenoic Acids - administration & dosage ; Docosahexaenoic Acids - metabolism ; electrospray ionization mass spectrometry ; Euphorbiaceae - chemistry ; Fatty acids ; Fish oils ; food intake ; image analysis ; Male ; males ; Mass spectrometry ; Maze Learning ; Medicine ; Memory ; Metabolites ; mice ; Neurogenesis ; Neurotransmission ; nut oils ; Nutrition research ; Nuts - chemistry ; Oils & fats ; omega-3 fatty acids ; phosphatidylcholines ; Phosphorylation ; Photonics ; Plant Oils - administration & dosage ; Plant Oils - metabolism ; Plukenetia volubilis ; Scientific imaging ; seeds ; Senescence ; Soybeans ; Spatial distribution ; Spectrometry, Mass, Electrospray Ionization ; Systematic review ; Tau protein ; Vegetable oils ; Womens health</subject><ispartof>Nutrients, 2019-10, Vol.11 (10), p.2371</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-b75f32fead031faefab82af96e2dcb1c20ab31a6c0b9249d17d3484aef147f5b3</citedby><cites>FETCH-LOGICAL-c505t-b75f32fead031faefab82af96e2dcb1c20ab31a6c0b9249d17d3484aef147f5b3</cites><orcidid>0000-0001-9274-3386 ; 0000-0001-7497-3540 ; 0000-0002-1302-6467</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835595/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835595/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31590339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takeyama, Emiko</creatorcontrib><creatorcontrib>Islam, Ariful</creatorcontrib><creatorcontrib>Watanabe, Nakamichi</creatorcontrib><creatorcontrib>Tsubaki, Hiroe</creatorcontrib><creatorcontrib>Fukushima, Masako</creatorcontrib><creatorcontrib>Mamun, Md Al</creatorcontrib><creatorcontrib>Sato, Shumpei</creatorcontrib><creatorcontrib>Sato, Tomohito</creatorcontrib><creatorcontrib>Eto, Fumihiro</creatorcontrib><creatorcontrib>Yao, Ikuko</creatorcontrib><creatorcontrib>Ito, Takashi K</creatorcontrib><creatorcontrib>Horikawa, Makoto</creatorcontrib><creatorcontrib>Setou, Mitsutoshi</creatorcontrib><title>Dietary Intake of Green Nut Oil or DHA Ameliorates DHA Distribution in the Brain of a Mouse Model of Dementia Accompanied by Memory Recovery</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has significant healthbenefits. Previous studies reported decreased levels of DHA and DHA-containing phosphatidylcholines inthe brain of animals suffering from Alzheimer's disease, the most common type of dementia; furthermore,DHA supplementation has been found to improve brain DHA levels and memory efficiency in dementia. Oilextracted from the seeds of
(green nut oil; GNO) is also expected to have DHA like effectsas it contains approximately 50% α-linolenic acid, a precursor of DHA. Despite this, changes in the spatialdistribution of DHA in the brain of animals with dementia following GNO or DHA supplementation remainunexplored. In this study, desorption electrospray ionization imaging mass spectrometry (DESI-IMS) wasapplied to observe the effects of GNO or DHA supplementation upon the distribution of DHA in the brain ofmale senescence-accelerated mouse-prone 8 (SAMP8) mice, a mouse model of dementia. DESI-IMS revealedthat brain DHA distribution increased 1.85-fold and 3.67-fold in GNO-fed and DHA-fed SAMP8 mice,respectively, compared to corn oil-fed SAMP8 mice. Memory efficiency in SAMP8 mice was also improvedby GNO or DHA supplementation. In summary, this study suggests the possibility of GNO or DHAsupplementation for the prevention of dementia.</description><subject>alpha-linolenic acid</subject><subject>Animal Feed</subject><subject>animal models</subject><subject>animal suffering</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Behavior, Animal</subject><subject>Blood-brain barrier</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Brain - physiopathology</subject><subject>Brain research</subject><subject>corn</subject><subject>Dementia</subject><subject>Dementia - metabolism</subject><subject>Dementia - physiopathology</subject><subject>Dementia - prevention & control</subject><subject>Dementia - psychology</subject><subject>Dementia disorders</subject><subject>desorption</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Disease Models, Animal</subject><subject>docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - administration & dosage</subject><subject>Docosahexaenoic Acids - metabolism</subject><subject>electrospray ionization mass spectrometry</subject><subject>Euphorbiaceae - chemistry</subject><subject>Fatty acids</subject><subject>Fish oils</subject><subject>food intake</subject><subject>image analysis</subject><subject>Male</subject><subject>males</subject><subject>Mass spectrometry</subject><subject>Maze Learning</subject><subject>Medicine</subject><subject>Memory</subject><subject>Metabolites</subject><subject>mice</subject><subject>Neurogenesis</subject><subject>Neurotransmission</subject><subject>nut oils</subject><subject>Nutrition research</subject><subject>Nuts - chemistry</subject><subject>Oils & fats</subject><subject>omega-3 fatty acids</subject><subject>phosphatidylcholines</subject><subject>Phosphorylation</subject><subject>Photonics</subject><subject>Plant Oils - administration & dosage</subject><subject>Plant Oils - metabolism</subject><subject>Plukenetia volubilis</subject><subject>Scientific imaging</subject><subject>seeds</subject><subject>Senescence</subject><subject>Soybeans</subject><subject>Spatial distribution</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Systematic review</subject><subject>Tau protein</subject><subject>Vegetable oils</subject><subject>Womens health</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkktrFTEUxwdRbKnd-AEk4EaEa_Oc3NkI115tC60F0XVIMic2dSa5TTKF-x380Gbs241ZJCfJ7_zPg9M0rwn-wFiHD8JECMGUSfKs2aVY0kXbcvb8kb3T7Od8ieclsWzZy2aHEdHh6r7b_F57KDpt0Uko-heg6NBRAgjo61TQuR9QTGh9vEKrEQYfky6Q_97XPpfkzVR8DMgHVC4AfUq6WlVBo7M4Zah7D8P8sIYRQvEarayN40YHDz0yW3QGY6yxv4GN15C2r5oXTg8Z9m_PvebHl8_fD48Xp-dHJ4er04UVWJSFkcIx6kD3mBGnwWmzpNp1LdDeGmIp1oYR3VpsOsq7nsie8SWvIOHSCcP2mo83upvJjNDbmlvSg9okP9ZWqKi9evoT_IX6Ga9Vu2RCdKIKvLsVSPFqglzU6LOFYdABauWKMkE5lbJ2__8oplxSuZzRt_-gl3FKoXaiUkTwlmMxx35_Q9kUc07g7vMmWM0joR5GosJvHld6j94NAPsDDeixYg</recordid><startdate>20191004</startdate><enddate>20191004</enddate><creator>Takeyama, Emiko</creator><creator>Islam, Ariful</creator><creator>Watanabe, Nakamichi</creator><creator>Tsubaki, Hiroe</creator><creator>Fukushima, Masako</creator><creator>Mamun, Md Al</creator><creator>Sato, Shumpei</creator><creator>Sato, Tomohito</creator><creator>Eto, Fumihiro</creator><creator>Yao, Ikuko</creator><creator>Ito, Takashi K</creator><creator>Horikawa, Makoto</creator><creator>Setou, Mitsutoshi</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9274-3386</orcidid><orcidid>https://orcid.org/0000-0001-7497-3540</orcidid><orcidid>https://orcid.org/0000-0002-1302-6467</orcidid></search><sort><creationdate>20191004</creationdate><title>Dietary Intake of Green Nut Oil or DHA Ameliorates DHA Distribution in the Brain of a Mouse Model of Dementia Accompanied by Memory Recovery</title><author>Takeyama, Emiko ; Islam, Ariful ; Watanabe, Nakamichi ; Tsubaki, Hiroe ; Fukushima, Masako ; Mamun, Md Al ; Sato, Shumpei ; Sato, Tomohito ; Eto, Fumihiro ; Yao, Ikuko ; Ito, Takashi K ; Horikawa, Makoto ; Setou, Mitsutoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-b75f32fead031faefab82af96e2dcb1c20ab31a6c0b9249d17d3484aef147f5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>alpha-linolenic acid</topic><topic>Animal Feed</topic><topic>animal models</topic><topic>animal suffering</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Behavior, Animal</topic><topic>Blood-brain barrier</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Brain - physiopathology</topic><topic>Brain research</topic><topic>corn</topic><topic>Dementia</topic><topic>Dementia - metabolism</topic><topic>Dementia - physiopathology</topic><topic>Dementia - prevention & control</topic><topic>Dementia - psychology</topic><topic>Dementia disorders</topic><topic>desorption</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>Disease Models, Animal</topic><topic>docosahexaenoic acid</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Docosahexaenoic Acids - metabolism</topic><topic>electrospray ionization mass spectrometry</topic><topic>Euphorbiaceae - chemistry</topic><topic>Fatty acids</topic><topic>Fish oils</topic><topic>food intake</topic><topic>image analysis</topic><topic>Male</topic><topic>males</topic><topic>Mass spectrometry</topic><topic>Maze Learning</topic><topic>Medicine</topic><topic>Memory</topic><topic>Metabolites</topic><topic>mice</topic><topic>Neurogenesis</topic><topic>Neurotransmission</topic><topic>nut oils</topic><topic>Nutrition research</topic><topic>Nuts - chemistry</topic><topic>Oils & fats</topic><topic>omega-3 fatty acids</topic><topic>phosphatidylcholines</topic><topic>Phosphorylation</topic><topic>Photonics</topic><topic>Plant Oils - administration & dosage</topic><topic>Plant Oils - metabolism</topic><topic>Plukenetia volubilis</topic><topic>Scientific imaging</topic><topic>seeds</topic><topic>Senescence</topic><topic>Soybeans</topic><topic>Spatial distribution</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Systematic review</topic><topic>Tau protein</topic><topic>Vegetable oils</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takeyama, Emiko</creatorcontrib><creatorcontrib>Islam, Ariful</creatorcontrib><creatorcontrib>Watanabe, Nakamichi</creatorcontrib><creatorcontrib>Tsubaki, Hiroe</creatorcontrib><creatorcontrib>Fukushima, Masako</creatorcontrib><creatorcontrib>Mamun, Md Al</creatorcontrib><creatorcontrib>Sato, Shumpei</creatorcontrib><creatorcontrib>Sato, Tomohito</creatorcontrib><creatorcontrib>Eto, Fumihiro</creatorcontrib><creatorcontrib>Yao, Ikuko</creatorcontrib><creatorcontrib>Ito, Takashi K</creatorcontrib><creatorcontrib>Horikawa, Makoto</creatorcontrib><creatorcontrib>Setou, Mitsutoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takeyama, Emiko</au><au>Islam, Ariful</au><au>Watanabe, Nakamichi</au><au>Tsubaki, Hiroe</au><au>Fukushima, Masako</au><au>Mamun, Md Al</au><au>Sato, Shumpei</au><au>Sato, Tomohito</au><au>Eto, Fumihiro</au><au>Yao, Ikuko</au><au>Ito, Takashi K</au><au>Horikawa, Makoto</au><au>Setou, Mitsutoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Intake of Green Nut Oil or DHA Ameliorates DHA Distribution in the Brain of a Mouse Model of Dementia Accompanied by Memory Recovery</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2019-10-04</date><risdate>2019</risdate><volume>11</volume><issue>10</issue><spage>2371</spage><pages>2371-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has significant healthbenefits. Previous studies reported decreased levels of DHA and DHA-containing phosphatidylcholines inthe brain of animals suffering from Alzheimer's disease, the most common type of dementia; furthermore,DHA supplementation has been found to improve brain DHA levels and memory efficiency in dementia. Oilextracted from the seeds of
(green nut oil; GNO) is also expected to have DHA like effectsas it contains approximately 50% α-linolenic acid, a precursor of DHA. Despite this, changes in the spatialdistribution of DHA in the brain of animals with dementia following GNO or DHA supplementation remainunexplored. In this study, desorption electrospray ionization imaging mass spectrometry (DESI-IMS) wasapplied to observe the effects of GNO or DHA supplementation upon the distribution of DHA in the brain ofmale senescence-accelerated mouse-prone 8 (SAMP8) mice, a mouse model of dementia. DESI-IMS revealedthat brain DHA distribution increased 1.85-fold and 3.67-fold in GNO-fed and DHA-fed SAMP8 mice,respectively, compared to corn oil-fed SAMP8 mice. Memory efficiency in SAMP8 mice was also improvedby GNO or DHA supplementation. In summary, this study suggests the possibility of GNO or DHAsupplementation for the prevention of dementia.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31590339</pmid><doi>10.3390/nu11102371</doi><orcidid>https://orcid.org/0000-0001-9274-3386</orcidid><orcidid>https://orcid.org/0000-0001-7497-3540</orcidid><orcidid>https://orcid.org/0000-0002-1302-6467</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | alpha-linolenic acid Animal Feed animal models animal suffering Animals Apoptosis Behavior, Animal Blood-brain barrier Brain Brain - metabolism Brain - physiopathology Brain research corn Dementia Dementia - metabolism Dementia - physiopathology Dementia - prevention & control Dementia - psychology Dementia disorders desorption Diet Dietary intake Disease Models, Animal docosahexaenoic acid Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - metabolism electrospray ionization mass spectrometry Euphorbiaceae - chemistry Fatty acids Fish oils food intake image analysis Male males Mass spectrometry Maze Learning Medicine Memory Metabolites mice Neurogenesis Neurotransmission nut oils Nutrition research Nuts - chemistry Oils & fats omega-3 fatty acids phosphatidylcholines Phosphorylation Photonics Plant Oils - administration & dosage Plant Oils - metabolism Plukenetia volubilis Scientific imaging seeds Senescence Soybeans Spatial distribution Spectrometry, Mass, Electrospray Ionization Systematic review Tau protein Vegetable oils Womens health |
| title | Dietary Intake of Green Nut Oil or DHA Ameliorates DHA Distribution in the Brain of a Mouse Model of Dementia Accompanied by Memory Recovery |
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