The glucose-6-phosphate dehydrogenase Mahidol variant protects against uncomplicated Plasmodium vivax infection and reduces disease severity in a Kachin population from northeast Myanmar

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common red cell disorders in the world. The aim of this study was to investigate whether the G6PD Mahidol variant and haplotype 1311 T/93C, which are prevalent in the Kachin ethnic population along the China-Myanmar border area,...

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Veröffentlicht in:	Infection, genetics and evolution genetics and evolution, 2019-11, Vol.75, p.103980-103980, Article 103980
Hauptverfasser:	Yi, Haoan, Li, Hong, Liang, Luxin, Wu, Yanrui, Zhang, Lu, Qiu, Wanfang, Jiang, Weiyang, Yang, Fang, Li, Qing, Yang, Zhaoqing, Wang, Chengqi, Cui, Liwang, He, Yongshu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged alleles Case-Control Studies Child Child, Preschool disease severity enzyme activity Female females G6PD Glucosephosphate Dehydrogenase - genetics Haplotype 1311T/93C Haplotypes hemizygote heterozygosity Humans Kachin population Mahidol variant Malaria Malaria - ethnology Malaria, Vivax - genetics Malaria, Vivax - parasitology Male males Middle Aged mutation Myanmar NADP-glucose-6-phosphate dehydrogenase odds ratio patients Plasmodium vivax Plasmodium vivax - pathogenicity Point Mutation regression analysis villages Young Adult
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