Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers

Recapitulating human disease pathophysiology using genetic animal models is a powerful approach to enable mechanistic understanding of genotype–phenotype relationships for drug development. NaV1.7 is a sodium channel expressed in the peripheral nervous system with strong human genetic validation as...

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Veröffentlicht in:	Molecular pain 2019, Vol.15, p.1744806919881846-1744806919881846
Hauptverfasser:	Grubinska, B, Chen, L, Alsaloum, M, Rampal, N, Matson, DJ, Yang, C, Taborn, K, Zhang, M, Youngblood, B, Liu, D, Galbreath, E, Allred, S, Lepherd, M, Ferrando, R, Kornecook, TJ, Lehto, SG, Waxman, SG, Moyer, BD, Dib-Hajj, S, Gingras, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Analgesics Animal models Binding sites Brain stem Capsaicin Dorsal root ganglia Drug development Genotypes Nervous system Nonsense mutation Olfaction Olfactory bulb Pain Pain perception Peripheral neuropathy Phenotypes Sciatic nerve Sodium channels (voltage-gated) Spinal nerves Stop codon Sulfonamides Tetrodotoxin Transcription
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