Relationship between inflammatory markers and visceral obesity in obese and overweight Korean adults: An observational study
Obesity is now considered a state of chronic low-grade inflammation. We investigated the relationship between several inflammatory markers and body composition for identifying patients with an increased risk of visceral obesity and compared the predictive values of inflammatory indices in visceral o...
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| Veröffentlicht in: | Medicine (Baltimore) 2019-03, Vol.98 (9), p.e14740-e14740 |
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| creator | Yu, Ju-Yeon Choi, Won-Jun Lee, Hye-Sun Lee, Ji-Won |
| description | Obesity is now considered a state of chronic low-grade inflammation. We investigated the relationship between several inflammatory markers and body composition for identifying patients with an increased risk of visceral obesity and compared the predictive values of inflammatory indices in visceral obesity.Six hundred individuals who received health checkups for obesity-related risk factors in Severance Hospital between January 2008 and March 2017 were included in our study. Serum inflammatory markers, such as white blood cell (WBC), high-sensitivity C-reactive protein (hsCRP), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) levels were assessed. Intra-abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were measured with computed tomography. We performed analysis of covariance, trend analysis, Steiger's Z tests, and multiple linear regression analysis to investigate associations between abdominal adiposity indices and inflammatory markers.Pearson's correlation analysis revealed a stronger association of VAT with WBC counts (r = 0.157, P |
| doi_str_mv | 10.1097/MD.0000000000014740 |
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We investigated the relationship between several inflammatory markers and body composition for identifying patients with an increased risk of visceral obesity and compared the predictive values of inflammatory indices in visceral obesity.Six hundred individuals who received health checkups for obesity-related risk factors in Severance Hospital between January 2008 and March 2017 were included in our study. Serum inflammatory markers, such as white blood cell (WBC), high-sensitivity C-reactive protein (hsCRP), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) levels were assessed. Intra-abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were measured with computed tomography. We performed analysis of covariance, trend analysis, Steiger's Z tests, and multiple linear regression analysis to investigate associations between abdominal adiposity indices and inflammatory markers.Pearson's correlation analysis revealed a stronger association of VAT with WBC counts (r = 0.157, P < .001) than with levels of NLR (r = 0.108, P = .11; Steiger's Z test, P = .04) and PLR (r = 0.036, P = .39; Steiger's Z test, P = .003). WBC and hsCRP levels linearly increased with VAT area (overall P < .001 and trend P < .001) and VAT/SAT ratio (overall P = .001 and trend P = .002; overall P < .001 and trend P < .001, respectively) but linearly decreased with SAT (overall P = .02 and trend P = .17; overall P = .03 and trend P = .01, respectively). Visceral adipose tissue area was more highly associated with WBC and hsCRP levels than with NLR and PLR. Only VAT area was significantly associated with WBC, hsCRP, and NLR levels after adjusting for confounding variables.We found that VAT, but not SAT area is independently associated with several inflammatory markers. WBC and hsCRP are more strongly correlated with VAT compared with NLR and PLR. Thus, WBC and hsCRP could be useful parameters for identifying individuals at risk for visceral obesity and cardiometabolic diseases.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000014740</identifier><identifier>PMID: 30817629</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Adult ; Body Mass Index ; Body Weights and Measures ; Female ; Health Behavior ; Hematologic Tests ; Humans ; Inflammation Mediators - blood ; Intra-Abdominal Fat - metabolism ; Male ; Middle Aged ; Obesity - blood ; Observational Study ; Overweight - blood ; Republic of Korea - epidemiology ; Young Adult</subject><ispartof>Medicine (Baltimore), 2019-03, Vol.98 (9), p.e14740-e14740</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4059-b3f0eac1b7165bb7de75d0d7d715b48de76e09081f60bdb851e168660d09e8a13</citedby><cites>FETCH-LOGICAL-c4059-b3f0eac1b7165bb7de75d0d7d715b48de76e09081f60bdb851e168660d09e8a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831265/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831265/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30817629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Ju-Yeon</creatorcontrib><creatorcontrib>Choi, Won-Jun</creatorcontrib><creatorcontrib>Lee, Hye-Sun</creatorcontrib><creatorcontrib>Lee, Ji-Won</creatorcontrib><title>Relationship between inflammatory markers and visceral obesity in obese and overweight Korean adults: An observational study</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Obesity is now considered a state of chronic low-grade inflammation. We investigated the relationship between several inflammatory markers and body composition for identifying patients with an increased risk of visceral obesity and compared the predictive values of inflammatory indices in visceral obesity.Six hundred individuals who received health checkups for obesity-related risk factors in Severance Hospital between January 2008 and March 2017 were included in our study. Serum inflammatory markers, such as white blood cell (WBC), high-sensitivity C-reactive protein (hsCRP), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) levels were assessed. Intra-abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were measured with computed tomography. We performed analysis of covariance, trend analysis, Steiger's Z tests, and multiple linear regression analysis to investigate associations between abdominal adiposity indices and inflammatory markers.Pearson's correlation analysis revealed a stronger association of VAT with WBC counts (r = 0.157, P < .001) than with levels of NLR (r = 0.108, P = .11; Steiger's Z test, P = .04) and PLR (r = 0.036, P = .39; Steiger's Z test, P = .003). WBC and hsCRP levels linearly increased with VAT area (overall P < .001 and trend P < .001) and VAT/SAT ratio (overall P = .001 and trend P = .002; overall P < .001 and trend P < .001, respectively) but linearly decreased with SAT (overall P = .02 and trend P = .17; overall P = .03 and trend P = .01, respectively). Visceral adipose tissue area was more highly associated with WBC and hsCRP levels than with NLR and PLR. Only VAT area was significantly associated with WBC, hsCRP, and NLR levels after adjusting for confounding variables.We found that VAT, but not SAT area is independently associated with several inflammatory markers. WBC and hsCRP are more strongly correlated with VAT compared with NLR and PLR. Thus, WBC and hsCRP could be useful parameters for identifying individuals at risk for visceral obesity and cardiometabolic diseases.</description><subject>Adult</subject><subject>Body Mass Index</subject><subject>Body Weights and Measures</subject><subject>Female</subject><subject>Health Behavior</subject><subject>Hematologic Tests</subject><subject>Humans</subject><subject>Inflammation Mediators - blood</subject><subject>Intra-Abdominal Fat - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Observational Study</subject><subject>Overweight - blood</subject><subject>Republic of Korea - epidemiology</subject><subject>Young Adult</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1vFCEUhonR2LX6C0zMXHozFYYBBi9Mmtav2MbE6DWB4UwHywwrMLvZxB8vu1vrBzdwOM95D4cXoecEnxEsxavryzP8Z5FWtPgBWhFGec0kbx-iFcYNq4UU7Ql6ktL3AlHRtI_RCcUdEbyRK_TzC3idXZjT6NaVgbwFmCs3D15Pk84h7qpJx1uIqdKzrTYu9RC1r4KB5PKukIcjHLJhA3EL7mbM1acQQc-VtovP6XV1vscSxM2hV6lPebG7p-jRoH2CZ3f7Kfr27u3Xiw_11ef3Hy_Or-q-xUzWhg4YdE-MIJwZIywIZrEVVhBm2q6EHLAsIw0cG2s6RoDwjnNssYROE3qK3hx114uZwPYw5zKDWkdXZtupoJ36NzO7Ud2EjeIdJQ1nReDlnUAMPxZIWU37j_BezxCWpBrSCUYJJbyg9Ij2MaQUYbhvQ7Da-6auL9X_vpWqF3-_8L7mt1EFaI_ANvhc3Lj1yxaiGkH7PB70mJBN3WAiMcUE1-WGS_oLarammA</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Yu, Ju-Yeon</creator><creator>Choi, Won-Jun</creator><creator>Lee, Hye-Sun</creator><creator>Lee, Ji-Won</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190301</creationdate><title>Relationship between inflammatory markers and visceral obesity in obese and overweight Korean adults: An observational study</title><author>Yu, Ju-Yeon ; Choi, Won-Jun ; Lee, Hye-Sun ; Lee, Ji-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4059-b3f0eac1b7165bb7de75d0d7d715b48de76e09081f60bdb851e168660d09e8a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Body Mass Index</topic><topic>Body Weights and Measures</topic><topic>Female</topic><topic>Health Behavior</topic><topic>Hematologic Tests</topic><topic>Humans</topic><topic>Inflammation Mediators - blood</topic><topic>Intra-Abdominal Fat - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Observational Study</topic><topic>Overweight - blood</topic><topic>Republic of Korea - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Ju-Yeon</creatorcontrib><creatorcontrib>Choi, Won-Jun</creatorcontrib><creatorcontrib>Lee, Hye-Sun</creatorcontrib><creatorcontrib>Lee, Ji-Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Ju-Yeon</au><au>Choi, Won-Jun</au><au>Lee, Hye-Sun</au><au>Lee, Ji-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between inflammatory markers and visceral obesity in obese and overweight Korean adults: An observational study</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>98</volume><issue>9</issue><spage>e14740</spage><epage>e14740</epage><pages>e14740-e14740</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Obesity is now considered a state of chronic low-grade inflammation. We investigated the relationship between several inflammatory markers and body composition for identifying patients with an increased risk of visceral obesity and compared the predictive values of inflammatory indices in visceral obesity.Six hundred individuals who received health checkups for obesity-related risk factors in Severance Hospital between January 2008 and March 2017 were included in our study. Serum inflammatory markers, such as white blood cell (WBC), high-sensitivity C-reactive protein (hsCRP), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) levels were assessed. Intra-abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were measured with computed tomography. We performed analysis of covariance, trend analysis, Steiger's Z tests, and multiple linear regression analysis to investigate associations between abdominal adiposity indices and inflammatory markers.Pearson's correlation analysis revealed a stronger association of VAT with WBC counts (r = 0.157, P < .001) than with levels of NLR (r = 0.108, P = .11; Steiger's Z test, P = .04) and PLR (r = 0.036, P = .39; Steiger's Z test, P = .003). WBC and hsCRP levels linearly increased with VAT area (overall P < .001 and trend P < .001) and VAT/SAT ratio (overall P = .001 and trend P = .002; overall P < .001 and trend P < .001, respectively) but linearly decreased with SAT (overall P = .02 and trend P = .17; overall P = .03 and trend P = .01, respectively). Visceral adipose tissue area was more highly associated with WBC and hsCRP levels than with NLR and PLR. Only VAT area was significantly associated with WBC, hsCRP, and NLR levels after adjusting for confounding variables.We found that VAT, but not SAT area is independently associated with several inflammatory markers. WBC and hsCRP are more strongly correlated with VAT compared with NLR and PLR. Thus, WBC and hsCRP could be useful parameters for identifying individuals at risk for visceral obesity and cardiometabolic diseases.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>30817629</pmid><doi>10.1097/MD.0000000000014740</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Body Mass Index Body Weights and Measures Female Health Behavior Hematologic Tests Humans Inflammation Mediators - blood Intra-Abdominal Fat - metabolism Male Middle Aged Obesity - blood Observational Study Overweight - blood Republic of Korea - epidemiology Young Adult |
| title | Relationship between inflammatory markers and visceral obesity in obese and overweight Korean adults: An observational study |
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