Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation

Activation of peroxisome proliferator-activated receptor (PPAR)-β/δ reduces tissue injury in murine endotoxemia. We hypothesized that the PPAR-β/δ-agonist GW0742 improves long-term outcome after sepsis caused by cecal ligation and puncture (CLP). Fifty-one CD-1 female mice underwent CLP and received...

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Veröffentlicht in:	Innate immunity (London, England) England), 2018-05, Vol.24 (4), p.262-273
Hauptverfasser:	Busch, Daniel, Kapoor, Amar, Rademann, Pia, Hildebrand, Frank, Bahrami, Soheyl, Thiemermann, Christoph, Osuchowski, Marcin F
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Animals Biochemical markers Blood Coagulation - drug effects Cecum Chemokines Clotting Coagulation Creatine Creatine kinase Creatinine Cytokines - blood Endotoxemia Female Fibrinogen Inflammation - drug therapy L-Lactate dehydrogenase Lactic acid Mice Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Original Peroxisome proliferator-activated receptors Plasminogen activator inhibitors PPAR delta - agonists PPAR delta - metabolism PPAR-beta - agonists PPAR-beta - metabolism Sepsis Sepsis - blood Sepsis - drug therapy Sepsis - mortality Sulfones - pharmacology Survival Thiazoles - therapeutic use Thiophenes - pharmacology Thrombin Triglycerides Urea γ-Interferon
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