Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450

Cytochromes P450 (P450s) are nature’s catalysts of choice for performing demanding and physiologically vital oxidation reactions. Biochemical characterization of these enzymes over the past decades has provided detailed mechanistic insight and highlighted the diversity of substrates P450s accommodat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2019-11, Vol.294 (44), p.15947-15961
Hauptverfasser:	DeMars, Matthew D., Samora, Nathan L., Yang, Song, Garcia-Borràs, Marc, Sanders, Jacob N., Houk, K.N., Podust, Larissa M., Sherman, David H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism cytochrome P450 enzyme structure Enzymology macrolide antibiotics molecular dynamics Molecular Dynamics Simulation natural product biosynthesis Protein Binding protein chimera Streptomyces Streptomyces - enzymology Substrate Specificity Tylosin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!