Homer1 mediates CaSR-dependent activation of mTOR complex 2 and initiates a novel pathway for AKT-dependent β-catenin stabilization in osteoblasts

The calcium-sensing receptor (CaSR) is critical for skeletal development, but its mechanism of action in osteoblasts is not well-characterized. In the central nervous system (CNS), Homer scaffolding proteins form signaling complexes with two CaSR-related members of the G protein–coupled receptor (GP...

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Veröffentlicht in:	The Journal of biological chemistry 2019-11, Vol.294 (44), p.16337-16350
Hauptverfasser:	Rybchyn, Mark S., Islam, Kazi S., Brennan-Speranza, Tara C., Cheng, Zhiqiang, Brennan, Sarah C., Chang, Wenhan, Mason, Rebecca S., Conigrave, Arthur David
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt PKB Animals Apoptosis - physiology beta Catenin - metabolism bone formation Calcium - metabolism calcium-sensing receptor (CaSR) cell signaling family C G-protein–coupled receptor Female G protein-coupled receptor (GPCR) HEK293 Cells Homer Scaffolding Proteins - metabolism Homer1 Humans Male Mechanistic Target of Rapamycin Complex 2 - metabolism Mice Mice, Inbred C57BL Mice, Knockout mTOR complex (mTORC) osteoblast Osteoblasts - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Receptors, Calcium-Sensing - genetics Receptors, Calcium-Sensing - metabolism scaffold protein Signal Transduction TOR Serine-Threonine Kinases - metabolism β-catenin
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