Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer
Photodynamic therapy (PDT) using porphyrins has been approved for treatment of several solid tumors due to the generation of cytotoxic reactive oxygen species (ROS). However, low physiological solubility and lack of selectivity towards tumor sites are the main limitations of their clinical use. Nano...
Gespeichert in:
| Veröffentlicht in: | Cancers 2019-10, Vol.11 (10), p.1474 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | 1474 |
| container_title | Cancers |
| container_volume | 11 |
| creator | Bretin, Ludovic Pinon, Aline Bouramtane, Soukaina Ouk, Catherine Richard, Laurence Perrin, Marie-Laure Chaunavel, Alain Carrion, Claire Bregier, Frédérique Sol, Vincent Chaleix, Vincent Leger, David Yannick Liagre, Bertrand |
| description | Photodynamic therapy (PDT) using porphyrins has been approved for treatment of several solid tumors due to the generation of cytotoxic reactive oxygen species (ROS). However, low physiological solubility and lack of selectivity towards tumor sites are the main limitations of their clinical use. Nanoparticles are able to spontaneously accumulate in solid tumors through an enhanced permeability and retention (EPR) effect due to leaky vasculature, poor lymphatic drainage, and increased vessel permeability. Herein, we proved the added value of nanoparticle vectorization on anticancer efficacy and tumor-targeting by 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin (TPPOH). Using 80 nm silica nanoparticles (SNPs) coated with xylan-TPPOH conjugate (TPPOH-X), we first showed very significant phototoxic effects of TPPOH-X SNPs mediated by post-PDT ROS generation and stronger cell uptake in human colorectal cancer cell lines compared to free TPPOH. Additionally, we demonstrated apoptotic cell death induced by TPPOH-X SNPs-PDT and the interest of autophagy inhibition to increase anticancer efficacy. Finally, we highlighted in vivo, without toxicity, elevated anticancer efficacy of TPPOH-X SNPs through improvement of tumor-targeting compared to a free TPPOH protocol. Our work demonstrated for the first time the strong anticancer efficacy of TPPOH in vitro and in vivo and the merit of SNPs vectorization. |
| doi_str_mv | 10.3390/cancers11101474 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6826978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2547515681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-bc5c5abaf3c0384d5dc7316dec6ad59dfb87a5c1b06a50def4e0efb00bf3b2e43</originalsourceid><addsrcrecordid>eNpdkU1v1DAQhiNERavSM1dLXOAQ6o_YSS5IqwhYpFWp1FbqzZrYDnFJ7GA7i_LvybIVgp3LjGbeeWY0k2VvCP7AWI2vFThlQiSEYFKUxYvsguKS5kLUxct_4vPsKsYnvBpjpBTlq-ycEV5yzOlF9uO298nrxcFoFbrvTYBpQRuV7N6mBfkO3Zhf6NaHqV-CdfnjMoDLGw_JaHRnB6sA3YDzE4Rk1WAisg5t5xEcavzgg1EJBtT82fR1dtbBEM3Vs7_MHj5_um-2-e7bl6_NZpergtGUt4orDi10TGFWFZprVTIitFECNK9111YlcEVaLIBjbbrCYNO1GLcda6kp2GX28cid5nY0WhmXAgxyCnaEsEgPVv5fcbaX3_1eioqKuqxWwPsjoD9p22528pDDtKgJ5vWerNp3z8OC_zmbmORoozLDeibj5ygpw5isXMFX6dsT6ZOfg1tPISkvSk64qA7A66NKBR9jMN3fDQiWh7_Lk7-z355jonA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2547515681</pqid></control><display><type>article</type><title>Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>Bretin, Ludovic ; Pinon, Aline ; Bouramtane, Soukaina ; Ouk, Catherine ; Richard, Laurence ; Perrin, Marie-Laure ; Chaunavel, Alain ; Carrion, Claire ; Bregier, Frédérique ; Sol, Vincent ; Chaleix, Vincent ; Leger, David Yannick ; Liagre, Bertrand</creator><creatorcontrib>Bretin, Ludovic ; Pinon, Aline ; Bouramtane, Soukaina ; Ouk, Catherine ; Richard, Laurence ; Perrin, Marie-Laure ; Chaunavel, Alain ; Carrion, Claire ; Bregier, Frédérique ; Sol, Vincent ; Chaleix, Vincent ; Leger, David Yannick ; Liagre, Bertrand</creatorcontrib><description>Photodynamic therapy (PDT) using porphyrins has been approved for treatment of several solid tumors due to the generation of cytotoxic reactive oxygen species (ROS). However, low physiological solubility and lack of selectivity towards tumor sites are the main limitations of their clinical use. Nanoparticles are able to spontaneously accumulate in solid tumors through an enhanced permeability and retention (EPR) effect due to leaky vasculature, poor lymphatic drainage, and increased vessel permeability. Herein, we proved the added value of nanoparticle vectorization on anticancer efficacy and tumor-targeting by 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin (TPPOH). Using 80 nm silica nanoparticles (SNPs) coated with xylan-TPPOH conjugate (TPPOH-X), we first showed very significant phototoxic effects of TPPOH-X SNPs mediated by post-PDT ROS generation and stronger cell uptake in human colorectal cancer cell lines compared to free TPPOH. Additionally, we demonstrated apoptotic cell death induced by TPPOH-X SNPs-PDT and the interest of autophagy inhibition to increase anticancer efficacy. Finally, we highlighted in vivo, without toxicity, elevated anticancer efficacy of TPPOH-X SNPs through improvement of tumor-targeting compared to a free TPPOH protocol. Our work demonstrated for the first time the strong anticancer efficacy of TPPOH in vitro and in vivo and the merit of SNPs vectorization.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers11101474</identifier><identifier>PMID: 31575052</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Apoptosis ; Autophagy ; Biocompatibility ; Cancer ; Cancer therapies ; Cell death ; Colorectal cancer ; Colorectal carcinoma ; Cytotoxicity ; Drug delivery systems ; Flow cytometry ; Life Sciences ; Nanoparticles ; Permeability ; Phagocytosis ; Pharmaceutical sciences ; Photodynamic therapy ; Porphyrins ; Reactive oxygen species ; Single-nucleotide polymorphism ; Solid tumors ; Tumor cell lines ; Xylan</subject><ispartof>Cancers, 2019-10, Vol.11 (10), p.1474</ispartof><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-bc5c5abaf3c0384d5dc7316dec6ad59dfb87a5c1b06a50def4e0efb00bf3b2e43</citedby><cites>FETCH-LOGICAL-c432t-bc5c5abaf3c0384d5dc7316dec6ad59dfb87a5c1b06a50def4e0efb00bf3b2e43</cites><orcidid>0000-0002-9880-7616 ; 0000-0003-4148-2598 ; 0000-0003-2419-8974 ; 0000-0002-2949-0512 ; 0000-0002-5324-3095 ; 0000-0003-0175-0156</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826978/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826978/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://hal.science/hal-02491059$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bretin, Ludovic</creatorcontrib><creatorcontrib>Pinon, Aline</creatorcontrib><creatorcontrib>Bouramtane, Soukaina</creatorcontrib><creatorcontrib>Ouk, Catherine</creatorcontrib><creatorcontrib>Richard, Laurence</creatorcontrib><creatorcontrib>Perrin, Marie-Laure</creatorcontrib><creatorcontrib>Chaunavel, Alain</creatorcontrib><creatorcontrib>Carrion, Claire</creatorcontrib><creatorcontrib>Bregier, Frédérique</creatorcontrib><creatorcontrib>Sol, Vincent</creatorcontrib><creatorcontrib>Chaleix, Vincent</creatorcontrib><creatorcontrib>Leger, David Yannick</creatorcontrib><creatorcontrib>Liagre, Bertrand</creatorcontrib><title>Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer</title><title>Cancers</title><description>Photodynamic therapy (PDT) using porphyrins has been approved for treatment of several solid tumors due to the generation of cytotoxic reactive oxygen species (ROS). However, low physiological solubility and lack of selectivity towards tumor sites are the main limitations of their clinical use. Nanoparticles are able to spontaneously accumulate in solid tumors through an enhanced permeability and retention (EPR) effect due to leaky vasculature, poor lymphatic drainage, and increased vessel permeability. Herein, we proved the added value of nanoparticle vectorization on anticancer efficacy and tumor-targeting by 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin (TPPOH). Using 80 nm silica nanoparticles (SNPs) coated with xylan-TPPOH conjugate (TPPOH-X), we first showed very significant phototoxic effects of TPPOH-X SNPs mediated by post-PDT ROS generation and stronger cell uptake in human colorectal cancer cell lines compared to free TPPOH. Additionally, we demonstrated apoptotic cell death induced by TPPOH-X SNPs-PDT and the interest of autophagy inhibition to increase anticancer efficacy. Finally, we highlighted in vivo, without toxicity, elevated anticancer efficacy of TPPOH-X SNPs through improvement of tumor-targeting compared to a free TPPOH protocol. Our work demonstrated for the first time the strong anticancer efficacy of TPPOH in vitro and in vivo and the merit of SNPs vectorization.</description><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Biocompatibility</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cell death</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Cytotoxicity</subject><subject>Drug delivery systems</subject><subject>Flow cytometry</subject><subject>Life Sciences</subject><subject>Nanoparticles</subject><subject>Permeability</subject><subject>Phagocytosis</subject><subject>Pharmaceutical sciences</subject><subject>Photodynamic therapy</subject><subject>Porphyrins</subject><subject>Reactive oxygen species</subject><subject>Single-nucleotide polymorphism</subject><subject>Solid tumors</subject><subject>Tumor cell lines</subject><subject>Xylan</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU1v1DAQhiNERavSM1dLXOAQ6o_YSS5IqwhYpFWp1FbqzZrYDnFJ7GA7i_LvybIVgp3LjGbeeWY0k2VvCP7AWI2vFThlQiSEYFKUxYvsguKS5kLUxct_4vPsKsYnvBpjpBTlq-ycEV5yzOlF9uO298nrxcFoFbrvTYBpQRuV7N6mBfkO3Zhf6NaHqV-CdfnjMoDLGw_JaHRnB6sA3YDzE4Rk1WAisg5t5xEcavzgg1EJBtT82fR1dtbBEM3Vs7_MHj5_um-2-e7bl6_NZpergtGUt4orDi10TGFWFZprVTIitFECNK9111YlcEVaLIBjbbrCYNO1GLcda6kp2GX28cid5nY0WhmXAgxyCnaEsEgPVv5fcbaX3_1eioqKuqxWwPsjoD9p22528pDDtKgJ5vWerNp3z8OC_zmbmORoozLDeibj5ygpw5isXMFX6dsT6ZOfg1tPISkvSk64qA7A66NKBR9jMN3fDQiWh7_Lk7-z355jonA</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Bretin, Ludovic</creator><creator>Pinon, Aline</creator><creator>Bouramtane, Soukaina</creator><creator>Ouk, Catherine</creator><creator>Richard, Laurence</creator><creator>Perrin, Marie-Laure</creator><creator>Chaunavel, Alain</creator><creator>Carrion, Claire</creator><creator>Bregier, Frédérique</creator><creator>Sol, Vincent</creator><creator>Chaleix, Vincent</creator><creator>Leger, David Yannick</creator><creator>Liagre, Bertrand</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9880-7616</orcidid><orcidid>https://orcid.org/0000-0003-4148-2598</orcidid><orcidid>https://orcid.org/0000-0003-2419-8974</orcidid><orcidid>https://orcid.org/0000-0002-2949-0512</orcidid><orcidid>https://orcid.org/0000-0002-5324-3095</orcidid><orcidid>https://orcid.org/0000-0003-0175-0156</orcidid></search><sort><creationdate>20191001</creationdate><title>Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer</title><author>Bretin, Ludovic ; Pinon, Aline ; Bouramtane, Soukaina ; Ouk, Catherine ; Richard, Laurence ; Perrin, Marie-Laure ; Chaunavel, Alain ; Carrion, Claire ; Bregier, Frédérique ; Sol, Vincent ; Chaleix, Vincent ; Leger, David Yannick ; Liagre, Bertrand</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-bc5c5abaf3c0384d5dc7316dec6ad59dfb87a5c1b06a50def4e0efb00bf3b2e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Apoptosis</topic><topic>Autophagy</topic><topic>Biocompatibility</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Cell death</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Cytotoxicity</topic><topic>Drug delivery systems</topic><topic>Flow cytometry</topic><topic>Life Sciences</topic><topic>Nanoparticles</topic><topic>Permeability</topic><topic>Phagocytosis</topic><topic>Pharmaceutical sciences</topic><topic>Photodynamic therapy</topic><topic>Porphyrins</topic><topic>Reactive oxygen species</topic><topic>Single-nucleotide polymorphism</topic><topic>Solid tumors</topic><topic>Tumor cell lines</topic><topic>Xylan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bretin, Ludovic</creatorcontrib><creatorcontrib>Pinon, Aline</creatorcontrib><creatorcontrib>Bouramtane, Soukaina</creatorcontrib><creatorcontrib>Ouk, Catherine</creatorcontrib><creatorcontrib>Richard, Laurence</creatorcontrib><creatorcontrib>Perrin, Marie-Laure</creatorcontrib><creatorcontrib>Chaunavel, Alain</creatorcontrib><creatorcontrib>Carrion, Claire</creatorcontrib><creatorcontrib>Bregier, Frédérique</creatorcontrib><creatorcontrib>Sol, Vincent</creatorcontrib><creatorcontrib>Chaleix, Vincent</creatorcontrib><creatorcontrib>Leger, David Yannick</creatorcontrib><creatorcontrib>Liagre, Bertrand</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bretin, Ludovic</au><au>Pinon, Aline</au><au>Bouramtane, Soukaina</au><au>Ouk, Catherine</au><au>Richard, Laurence</au><au>Perrin, Marie-Laure</au><au>Chaunavel, Alain</au><au>Carrion, Claire</au><au>Bregier, Frédérique</au><au>Sol, Vincent</au><au>Chaleix, Vincent</au><au>Leger, David Yannick</au><au>Liagre, Bertrand</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer</atitle><jtitle>Cancers</jtitle><date>2019-10-01</date><risdate>2019</risdate><volume>11</volume><issue>10</issue><spage>1474</spage><pages>1474-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Photodynamic therapy (PDT) using porphyrins has been approved for treatment of several solid tumors due to the generation of cytotoxic reactive oxygen species (ROS). However, low physiological solubility and lack of selectivity towards tumor sites are the main limitations of their clinical use. Nanoparticles are able to spontaneously accumulate in solid tumors through an enhanced permeability and retention (EPR) effect due to leaky vasculature, poor lymphatic drainage, and increased vessel permeability. Herein, we proved the added value of nanoparticle vectorization on anticancer efficacy and tumor-targeting by 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin (TPPOH). Using 80 nm silica nanoparticles (SNPs) coated with xylan-TPPOH conjugate (TPPOH-X), we first showed very significant phototoxic effects of TPPOH-X SNPs mediated by post-PDT ROS generation and stronger cell uptake in human colorectal cancer cell lines compared to free TPPOH. Additionally, we demonstrated apoptotic cell death induced by TPPOH-X SNPs-PDT and the interest of autophagy inhibition to increase anticancer efficacy. Finally, we highlighted in vivo, without toxicity, elevated anticancer efficacy of TPPOH-X SNPs through improvement of tumor-targeting compared to a free TPPOH protocol. Our work demonstrated for the first time the strong anticancer efficacy of TPPOH in vitro and in vivo and the merit of SNPs vectorization.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>31575052</pmid><doi>10.3390/cancers11101474</doi><orcidid>https://orcid.org/0000-0002-9880-7616</orcidid><orcidid>https://orcid.org/0000-0003-4148-2598</orcidid><orcidid>https://orcid.org/0000-0003-2419-8974</orcidid><orcidid>https://orcid.org/0000-0002-2949-0512</orcidid><orcidid>https://orcid.org/0000-0002-5324-3095</orcidid><orcidid>https://orcid.org/0000-0003-0175-0156</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6694 |
| ispartof | Cancers, 2019-10, Vol.11 (10), p.1474 |
| issn | 2072-6694 2072-6694 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6826978 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Apoptosis Autophagy Biocompatibility Cancer Cancer therapies Cell death Colorectal cancer Colorectal carcinoma Cytotoxicity Drug delivery systems Flow cytometry Life Sciences Nanoparticles Permeability Phagocytosis Pharmaceutical sciences Photodynamic therapy Porphyrins Reactive oxygen species Single-nucleotide polymorphism Solid tumors Tumor cell lines Xylan |
| title | Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T03%3A33%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Photodynamic%20Therapy%20Activity%20of%20New%20Porphyrin-Xylan-Coated%20Silica%20Nanoparticles%20in%20Human%20Colorectal%20Cancer&rft.jtitle=Cancers&rft.au=Bretin,%20Ludovic&rft.date=2019-10-01&rft.volume=11&rft.issue=10&rft.spage=1474&rft.pages=1474-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers11101474&rft_dat=%3Cproquest_pubme%3E2547515681%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2547515681&rft_id=info:pmid/31575052&rfr_iscdi=true |