Inhibition of TFF3 Enhances Sensitivity—and Overcomes Acquired Resistance—to Doxorubicin in Estrogen Receptor-Positive Mammary Carcinoma

Dose-dependent toxicity and acquired resistance are two major challenges limiting the efficacious treatment of mammary carcinoma (MC) with doxorubicin. Herein, we investigated the function of Trefoil Factor 3 (TFF3) in the sensitivity and acquired resistance of estrogen receptor positive (ER+) MC ce...

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Veröffentlicht in:	Cancers 2019-10, Vol.11 (10), p.1528
Hauptverfasser:	Poh, Han, Chiou, Yi, Chong, Qing, Chen, Ru-Mei, Rangappa, Kanchugarakoppal, Ma, Lan, Zhu, Tao, Kumar, Alan, Pandey, Vijay, Basappa, Lee, Soo-Chin, Lobie, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Apoptosis Cancer therapies Carcinoma Doxorubicin Drug dosages Estrogen receptors Gene expression Kinases Mammary gland Proteins siRNA Toxicity Trefoil factor Xenografts
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