Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

Parkinson's disease prevalence is rapidly increasing in an aging global population. With this increase comes exponentially rising social and economic costs, emphasizing the immediate need for effective disease‐modifying treatments. Motor dysfunction results from the loss of dopaminergic neurons...

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Veröffentlicht in:	Aging cell 2019-12, Vol.18 (6), p.e13031-n/a
Hauptverfasser:	Trist, Benjamin G., Hare, Dominic J., Double, Kay L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Animals antioxidant Calcium - metabolism Causes and theories of causation Cell death Cellular Senescence Development and progression Diseases Dopamine Dopamine receptors Etiology Humans Mitochondria - metabolism Mitochondria - pathology Movement disorders Neurodegenerative diseases Neurons Neurophysiology Neurotransmission Oxidative Stress Parkinson Disease - etiology Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease reactive oxygen species Review Reviews Substantia nigra Substantia Nigra - metabolism Substantia Nigra - pathology
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