Tau oligomers mediate aggregation of RNA‐binding proteins Musashi1 and Musashi2 inducing Lamin alteration

The exact mechanisms leading to neurodegeneration in Alzheimer's disease (AD) and other tauopathies are not yet entirely understood. However, it is known that several RNA‐binding proteins (RBPs) form toxic aggregates and also interact with tau in such granules in tauopathies, including AD. The...

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Veröffentlicht in:	Aging cell 2019-12, Vol.18 (6), p.e13035-n/a
Hauptverfasser:	Montalbano, Mauro, McAllen, Salome, Sengupta, Urmi, Puangmalai, Nicha, Bhatt, Nemil, Ellsworth, Anna, Kayed, Rakez
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Alzheimer's disease Analysis Binding proteins Cell Line Cytoplasm Ethylenediaminetetraacetic acid Humans Lamin Type B - metabolism Localization Medical research Medicine, Experimental Musashi Mutants Nerve Tissue Proteins - metabolism Nervous system diseases Neurodegeneration Neurodegenerative diseases nuclear dysfunction Nuclear transport Oligomers Original Protein Aggregates protein aggregation Protein binding Proteins Ribonucleic acid RNA RNA-Binding Proteins - metabolism tau Tau protein tau Proteins - metabolism Tetracycline Tetracyclines
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