Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) is often sensitive to initial treatment with platinum and taxane combination chemotherapy, but most patients relapse with chemotherapy-resistant disease. To systematically identify genes modulating chemotherapy response, we performed pooled functional genomic...

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Veröffentlicht in:	Molecular cancer research 2019-11, Vol.17 (11), p.2281-2293
Hauptverfasser:	Stover, Elizabeth H, Baco, Maria B, Cohen, Ofir, Li, Yvonne Y, Christie, Elizabeth L, Bagul, Mukta, Goodale, Amy, Lee, Yenarae, Pantel, Sasha, Rees, Matthew G, Wei, Guo, Presser, Adam G, Gelbard, Maya K, Zhang, Weiqun, Zervantonakis, Ioannis K, Bhola, Patrick D, Ryan, Jeremy, Guerriero, Jennifer L, Montero, Joan, Liang, Felice J, Cherniack, Andrew D, Piccioni, Federica, Matulonis, Ursula A, Bowtell, David D L, Sarosiek, Kristopher A, Letai, Anthony, Garraway, Levi A, Johannessen, Cory M, Meyerson, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - genetics Apoptosis Regulatory Proteins - genetics bcl-X Protein - antagonists & inhibitors bcl-X Protein - genetics bcl-X Protein - metabolism Cell Line, Tumor Cisplatin - pharmacology Drug Resistance, Neoplasm Female Genomics Humans Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors Myeloid Cell Leukemia Sequence 1 Protein - genetics Myeloid Cell Leukemia Sequence 1 Protein - metabolism Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Paclitaxel - pharmacology
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