Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities

Immune checkpoint (IC) therapy provides substantial benefits to cancer patients but can also cause distinctive toxicities termed immune-related adverse events (irAEs). Biomarkers to predict toxicities will be necessary to improve management of patients receiving IC therapy. We relied on serological...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-10, Vol.116 (44), p.22246-22251
Hauptverfasser:	Tahir, Salahaldin A., Gao, Jianjun, Miura, Yuji, Blando, Jorge, Tidwell, Rebecca S. S., Zhao, Hao, Subudhi, Sumit K., Tawbi, Hussein, Keung, Emily, Wargo, Jennifer, Allison, James P., Sharma, Padmanee
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - immunology Aged Antibodies Autoantibodies Autoantibodies - blood Autoantibodies - immunology Autoantibodies - toxicity Autoimmune Hypophysitis - diagnosis Autoimmune Hypophysitis - etiology Autoimmune Hypophysitis - immunology Biological Sciences Biomarkers Biomarkers - blood Correlation Enzyme-linked immunosorbent assay Female GTP-Binding Protein alpha Subunits, Gi-Go - immunology Humans Immune checkpoint Immunotherapy - adverse effects Male Middle Aged Neoplasms - therapy Pneumonia - etiology Pneumonia - immunology Pneumonitis Pretreatment Therapy Toxicity
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