Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma

Targeting the function of membrane transporters in cancer stemlike cells is a potential new therapeutic approach. Cystine‐glutamate antiporter xCT expressed in CD44 variant (CD44v)‐expressing cancer cells contributes to the resistance to oxidative stress as well as cancer therapy through promoting g...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer science 2019-11, Vol.110 (11), p.3453-3463
Hauptverfasser:	Okazaki, Shogo, Umene, Kiyoko, Yamasaki, Juntaro, Suina, Kentaro, Otsuki, Yuji, Yoshikawa, Momoko, Minami, Yushi, Masuko, Takashi, Kawaguchi, Sho, Nakayama, Hideki, Banno, Kouji, Aoki, Daisuke, Saya, Hideyuki, Nagano, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Amino Acid Transport System ASC - genetics Amino Acid Transport System y+ - antagonists & inhibitors Amino Acid Transport System y+ - metabolism Amino acids Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antineoplastic Agents - pharmacology Antioxidants Apoptosis ASCT2 Cancer Capillary electrophoresis CD44 antigen CD44 variant Cell Adhesion Cell Differentiation Cell Line, Tumor Cisplatin - pharmacology Cytotoxicity Dehydrogenases Genes Glutamate dehydrogenase Glutamate Dehydrogenase - metabolism Glutamine Glutamine - metabolism Glutathione Glutathione - metabolism Head & neck cancer head and neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Homeostasis Humans Hyaluronan Receptors - analysis Hyaluronan Receptors - metabolism Infections Ketoglutaric acid Ketoglutaric Acids - metabolism Mass spectrometry Medical prognosis Medical research Metabolism Metabolome Mice Mice, Nude Minor Histocompatibility Antigens - genetics Mitochondria Mitochondria - metabolism Molecular Targeted Therapy - methods Neoplastic Stem Cells - metabolism Original Oxidation-Reduction Oxidative Stress Phosphorylation Polyclonal antibodies R&D Reactive oxygen species Research & development Respiration RNA, Messenger - metabolism Scientific imaging Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - drug therapy Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - metabolism Squamous Cell Carcinoma of Head and Neck - pathology Sulfasalazine Sulfasalazine - pharmacology Tricarboxylic acid cycle Tumors xCT
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!