UGCG influences glutamine metabolism of breast cancer cells

UDP-glucose ceramide glucosyltransferase (UGCG) is the key enzyme in glycosphingolipid (GSL) metabolism by being the only enzyme that generates glucosylceramide (GlcCer) de novo . Increased UGCG synthesis is associated with pro-cancerous processes such as increased proliferation and multidrug resist...

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Veröffentlicht in:	Scientific reports 2019-10, Vol.9 (1), p.15665-13, Article 15665
Hauptverfasser:	Schömel, Nina, Hancock, Sarah E., Gruber, Lisa, Olzomer, Ellen M., Byrne, Frances L., Shah, Divya, Hoehn, Kyle L., Turner, Nigel, Grösch, Sabine, Geisslinger, Gerd, Wegner, Marthe-Susanna
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 13 13/51 42 631/67/1347 631/67/2327 82 82/80 96 96/63 Breast cancer Breast Neoplasms - pathology Ceramide Ceramide glucosyltransferase Disulfide reductase Energy Metabolism Enzymes Gene expression Gene Expression Regulation, Neoplastic Glucose - metabolism Glucose Transport Proteins, Facilitative - genetics Glucosyltransferase Glucosyltransferases - genetics Glucosyltransferases - metabolism Glutamine Glutamine - metabolism Glutathione Humanities and Social Sciences Humans MCF-7 Cells Metabolism multidisciplinary Multidrug resistance Oxidation-Reduction Oxidative Stress RNA, Messenger - genetics Science Science (multidisciplinary) Tricarboxylic acid cycle
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