More than efficacy revealed by single-cell analysis of antiviral therapeutics

Because many aspects of viral infection dynamics and inhibition are governed by stochastic processes, single-cell analysis should provide more information than approaches using population averaging. We have developed a microfluidic device composed of ~6000 wells, with each well containing a microstr...

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Veröffentlicht in:	Science advances 2019-10, Vol.5 (10), p.eaax4761
Hauptverfasser:	Liu, Wu, Caglar, Mehmet U, Mao, Zhangming, Woodman, Andrew, Arnold, Jamie J, Wilke, Claus O, Cameron, Craig E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - therapeutic use Drug Therapy, Combination HeLa Cells HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - metabolism Humans Microfluidics Nucleic Acid Synthesis Inhibitors - therapeutic use Poliovirus - enzymology Principal Component Analysis Protease Inhibitors - therapeutic use SciAdv r-articles Single-Cell Analysis Systems Biology Virology
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