Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema

The majority of patients with diabetic macular edema (DME), the most common cause of vision loss in working-age Americans, do not respond adequately to current therapies targeting VEGFA. Here, we show that expression of angiopoietin-like 4 (ANGPTL4), a HIF-1-regulated gene product, is increased in t...

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Veröffentlicht in:	The Journal of clinical investigation 2019-11, Vol.129 (11), p.4593-4608
Hauptverfasser:	Sodhi, Akrit, Ma, Tao, Menon, Deepak, Deshpande, Monika, Jee, Kathleen, Dinabandhu, Aumreetam, Vancel, Jordan, Lu, Daoyuan, Montaner, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiopoietin Angiopoietin-Like Protein 4 - metabolism Animals Biomedical research Cancer Cardiovascular disease Development and progression Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic retinopathy Diabetic Retinopathy - metabolism Diabetic Retinopathy - pathology Edema Endothelial cells Endothelial growth factors Endothelium Genes Heparan sulfate Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - pathology Humans Kinases Macular Edema - metabolism Macular Edema - pathology Metabolism Mice Mutation Neuropilin Neuropilin-1 - metabolism Neuropilin-2 - metabolism Permeability Phenols (Class of compounds) Phosphorylation Proteins Retina Retinal Vessels - metabolism Retinal Vessels - pathology Rho-associated kinase rhoA GTP-Binding Protein - metabolism RhoA protein Signal Transduction Software industry Therapeutic applications Type 2 diabetes Tyrosine Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism
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