Tumor acidity activated triphenylphosphonium-based mitochondrial targeting nanocarriers for overcoming drug resistance of cancer therapy

The drug resistance in cancer treatment with DOX is mainly related to the overexpression of drug efflux proteins, residing in the plasma and nuclear membranes. Delivering DOX into the mitochondria, lacking drug efflux proteins, is an interesting method to overcome DOX resistance. To solve the proble...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Theranostics 2019-01, Vol.9 (23), p.7033-7050
Hauptverfasser:	Yu, Hui, Li, Jia-Mi, Deng, Kai, Zhou, Wei, Wang, Cai-Xia, Wang, Qian, Li, Kun-Heng, Zhao, Hong-Yang, Huang, Shi-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Breast cancer Cancer therapies Chemotherapy Drug resistance Ligands Lipids Mitochondria Nanoparticles Polymers Proteins Research Paper
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!