Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation

Artemisitene (ATT) activates the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) by increasing its stabilization and reducing ubiquitination. The cysteine (Cys) residues of the cytosolic Nrf2 repressor Kelch-like ECH-associated protein-1 (Keap1) function as redox sensors and may be crucial in act...

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Veröffentlicht in:	BioMed research international 2019, Vol.2019 (2019), p.1-8
Hauptverfasser:	Chen, Weimin, Li, Wenjuan, Xie, Li, Wei, Renxiong, Wu, Xiaoyun, Cui, Zhizhong, Wei, Renrong, Xu, Shengmei, Liu, Shanshan, Zhou, Yingye
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Activation Amino Acid Substitution - genetics Antioxidants Artemisinins - pharmacology Biomedical research Cell lines Cellular biology Cysteine - genetics Enzymes Genes Genetic transcription Humans Kelch-Like ECH-Associated Protein 1 - genetics Mutagenesis Mutant Proteins - genetics NF-E2-Related Factor 2 - genetics Oxidation-Reduction Oxidative stress Plasmids Proteins Serine - genetics Stabilization Transcription Transcription factors Transcriptional Activation - genetics Ubiquitin Ubiquitination
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