Glycan targeted polymeric antibiotic prodrugs for alveolar macrophage infections

Alveolar macrophages resident in the lung are prominent phagocytic effector cells of the pulmonary innate immune response, and paradoxically, are attractive harbors for pathogens. Consequently, facultative intracellular bacteria, such as Francisella tularensis, can cause severe systemic disease and...

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Veröffentlicht in:	Biomaterials 2019-03, Vol.195, p.38-50
Hauptverfasser:	Chen, Jasmin, Su, Fang-Yi, Das, Debobrato, Srinivasan, Selvi, Son, Hye-Nam, Lee, Brian, Radella, Frank, Whittington, Dale, Monroe-Jones, Taylor, West, T. Eoin, Convertine, Anthony J., Skerrett, Shawn J., Stayton, Patrick S., Ratner, Daniel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar macrophage Antibiotic prodrug Francisella tularensis - metabolism Glycopolymer Intracellular infection Macrophages, Alveolar - metabolism Magnetic Resonance Spectroscopy Mannose Mannose - metabolism Microbial Sensitivity Tests Polysaccharides - chemistry Prodrugs - chemistry
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