Immunolocalization of calcium sensing and transport proteins in the murine endolymphatic sac indicates calciostatic functions within the inner ear
An exceptionally low calcium (Ca 2+ ) concentration in the inner ear endolymph ([Ca 2+ ] endolymph ) is crucial for proper auditory and vestibular function. The endolymphatic sac (ES) is believed to critically contribute to the maintenance of this low [Ca 2+ ] endolymph . Here, we investigated the i...
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| Veröffentlicht in: | Cell and tissue research 2019-11, Vol.378 (2), p.163-173 |
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| creator | Bächinger, David Egli, Hannes Goosmann, Madeline M. Monge Naldi, Arianne Eckhard, Andreas H. |
| description | An exceptionally low calcium (Ca
2+
) concentration in the inner ear endolymph ([Ca
2+
]
endolymph
) is crucial for proper auditory and vestibular function. The endolymphatic sac (ES) is believed to critically contribute to the maintenance of this low [Ca
2+
]
endolymph
. Here, we investigated the immunohistochemical localization of proteins that are presumably involved in the sensing and transport of extracellular Ca
2+
in the murine ES epithelium. Light microscopic and fluorescence immunolabeling in paraffin-embedded murine ES tissue sections (male C57BL/6 mice, 6–8 weeks old) demonstrated the presence of the calcium-sensing receptor CaSR, transient receptor potential cation channel subtypes TRPV5 and TRPV6, sarco/endoplasmic reticulum Ca
2+
-ATPases SERCA1 and SERCA2, Na
+
/Ca
2+
exchanger NCX2, and plasma membrane Ca
2+
ATPases PMCA1 and PMCA4 in ES epithelial cells. These proteins exhibited (i) membranous (apical or basolateral) or cytoplasmic localization patterns, (ii) a proximal-to-distal labeling gradient within the ES, and (iii) different distribution patterns among ES epithelial cell types (mitochondria-rich cells (MRCs) and ribosome-rich cells (RRCs)). Notably, in the inner ear membranous labyrinth, CaSR was exclusively localized in MRCs, suggesting a unique role of the ES epithelium in CaSR-mediated sensing and control of [Ca
2+
]
endolymph
. Structural loss of the distal ES, which is consistently observed in Meniere’s disease, may therefore critically disturb [Ca
2+
]
endolymph
and contribute to the pathogenesis of Meniere’s disease. |
| doi_str_mv | 10.1007/s00441-019-03062-2 |
| format | Article |
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2+
) concentration in the inner ear endolymph ([Ca
2+
]
endolymph
) is crucial for proper auditory and vestibular function. The endolymphatic sac (ES) is believed to critically contribute to the maintenance of this low [Ca
2+
]
endolymph
. Here, we investigated the immunohistochemical localization of proteins that are presumably involved in the sensing and transport of extracellular Ca
2+
in the murine ES epithelium. Light microscopic and fluorescence immunolabeling in paraffin-embedded murine ES tissue sections (male C57BL/6 mice, 6–8 weeks old) demonstrated the presence of the calcium-sensing receptor CaSR, transient receptor potential cation channel subtypes TRPV5 and TRPV6, sarco/endoplasmic reticulum Ca
2+
-ATPases SERCA1 and SERCA2, Na
+
/Ca
2+
exchanger NCX2, and plasma membrane Ca
2+
ATPases PMCA1 and PMCA4 in ES epithelial cells. These proteins exhibited (i) membranous (apical or basolateral) or cytoplasmic localization patterns, (ii) a proximal-to-distal labeling gradient within the ES, and (iii) different distribution patterns among ES epithelial cell types (mitochondria-rich cells (MRCs) and ribosome-rich cells (RRCs)). Notably, in the inner ear membranous labyrinth, CaSR was exclusively localized in MRCs, suggesting a unique role of the ES epithelium in CaSR-mediated sensing and control of [Ca
2+
]
endolymph
. Structural loss of the distal ES, which is consistently observed in Meniere’s disease, may therefore critically disturb [Ca
2+
]
endolymph
and contribute to the pathogenesis of Meniere’s disease.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-019-03062-2</identifier><identifier>PMID: 31338584</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenosine triphosphatase ; Animals ; Auditory system ; Biomedical and Life Sciences ; Biomedicine ; Ca2+-transporting ATPase ; Calcium (extracellular) ; Calcium (reticular) ; Calcium - metabolism ; Calcium transport ; Calcium-sensing receptors ; Carrier proteins ; Carrier Proteins - metabolism ; Endolymph - metabolism ; Endolymphatic Sac - metabolism ; Endoplasmic reticulum ; Epithelial cells ; Epithelium ; Epithelium - metabolism ; Ethylenediaminetetraacetic acid ; Human Genetics ; Inner ear ; Localization ; Male ; Meniere Disease - metabolism ; Meniere's disease ; Mice ; Mice, Inbred C57BL ; Mitochondria ; Molecular Medicine ; Na+/Ca2+ exchanger ; Paraffin ; Proteins ; Proteomics ; Regular ; Regular Article ; Transient receptor potential proteins ; Vestibular system</subject><ispartof>Cell and tissue research, 2019-11, Vol.378 (2), p.163-173</ispartof><rights>The Author(s) 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Cell and Tissue Research is a copyright of Springer, (2019). All Rights Reserved. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-3c7d11dac56e34aaa35bdf58e55423f00a17ffcf3d170bab2c056a125f309fa83</citedby><cites>FETCH-LOGICAL-c572t-3c7d11dac56e34aaa35bdf58e55423f00a17ffcf3d170bab2c056a125f309fa83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00441-019-03062-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00441-019-03062-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31338584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bächinger, David</creatorcontrib><creatorcontrib>Egli, Hannes</creatorcontrib><creatorcontrib>Goosmann, Madeline M.</creatorcontrib><creatorcontrib>Monge Naldi, Arianne</creatorcontrib><creatorcontrib>Eckhard, Andreas H.</creatorcontrib><title>Immunolocalization of calcium sensing and transport proteins in the murine endolymphatic sac indicates calciostatic functions within the inner ear</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><addtitle>Cell Tissue Res</addtitle><description>An exceptionally low calcium (Ca
2+
) concentration in the inner ear endolymph ([Ca
2+
]
endolymph
) is crucial for proper auditory and vestibular function. The endolymphatic sac (ES) is believed to critically contribute to the maintenance of this low [Ca
2+
]
endolymph
. Here, we investigated the immunohistochemical localization of proteins that are presumably involved in the sensing and transport of extracellular Ca
2+
in the murine ES epithelium. Light microscopic and fluorescence immunolabeling in paraffin-embedded murine ES tissue sections (male C57BL/6 mice, 6–8 weeks old) demonstrated the presence of the calcium-sensing receptor CaSR, transient receptor potential cation channel subtypes TRPV5 and TRPV6, sarco/endoplasmic reticulum Ca
2+
-ATPases SERCA1 and SERCA2, Na
+
/Ca
2+
exchanger NCX2, and plasma membrane Ca
2+
ATPases PMCA1 and PMCA4 in ES epithelial cells. These proteins exhibited (i) membranous (apical or basolateral) or cytoplasmic localization patterns, (ii) a proximal-to-distal labeling gradient within the ES, and (iii) different distribution patterns among ES epithelial cell types (mitochondria-rich cells (MRCs) and ribosome-rich cells (RRCs)). Notably, in the inner ear membranous labyrinth, CaSR was exclusively localized in MRCs, suggesting a unique role of the ES epithelium in CaSR-mediated sensing and control of [Ca
2+
]
endolymph
. Structural loss of the distal ES, which is consistently observed in Meniere’s disease, may therefore critically disturb [Ca
2+
]
endolymph
and contribute to the pathogenesis of Meniere’s disease.</description><subject>Adenosine triphosphatase</subject><subject>Animals</subject><subject>Auditory system</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Ca2+-transporting ATPase</subject><subject>Calcium (extracellular)</subject><subject>Calcium (reticular)</subject><subject>Calcium - metabolism</subject><subject>Calcium transport</subject><subject>Calcium-sensing receptors</subject><subject>Carrier proteins</subject><subject>Carrier Proteins - metabolism</subject><subject>Endolymph - metabolism</subject><subject>Endolymphatic Sac - metabolism</subject><subject>Endoplasmic reticulum</subject><subject>Epithelial cells</subject><subject>Epithelium</subject><subject>Epithelium - metabolism</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Human Genetics</subject><subject>Inner ear</subject><subject>Localization</subject><subject>Male</subject><subject>Meniere Disease - metabolism</subject><subject>Meniere's disease</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mitochondria</subject><subject>Molecular Medicine</subject><subject>Na+/Ca2+ exchanger</subject><subject>Paraffin</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Regular</subject><subject>Regular Article</subject><subject>Transient receptor potential proteins</subject><subject>Vestibular system</subject><issn>0302-766X</issn><issn>1432-0878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ktuKFDEQhhtR3HX1BbyQgCDe9JpDJ91zIyyLh4UFbxS8CzXpynSW7mRM0ivrY_jEZg6OOyKSi5Cqr_6iKn9VPWf0nFHavkmUNg2rKVvUVFDFa_6gOmWN4DXt2u5hdVqivG6V-npSPUnphlLWKLV4XJ0IJkQnu-a0-nk1TbMPYzAwuh-QXfAkWFJexs0TSeiT8ysCvic5gk_rEDNZx5DR-UScJ3lAMs3ReSTo-zDeTeuhyBiSwJR87wxkTDvBkPI2ZWdvNp0S-e7ysBdx3mMkCPFp9cjCmPDZ_j6rvrx_9_nyY3396cPV5cV1bWTLcy1M2zPWg5EKRQMAQi57KzuUsuHCUgqstdZY0bOWLmHJDZUKGJdW0IWFTpxVb3e663k5YW_QlwlHvY5ugninAzh9nPFu0Ktwq1XHJO9UEXi9F4jh24wp68klg-MIHsOcNOdKCC4EpQV9-Rd6E-boy3gbisumbcvHHagVjKidt6H0NRtRfaGoWLRSclmo839Q5fQ4ORM8WlfiRwWv7hUMCGMeUhjn7Rccg3wHmhhSimgPy2BUbyynd5bTxXJ6aznNS9GL-2s8lPz2WAHEDkgl5VcY_8z-H9lf-4jkWg</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Bächinger, David</creator><creator>Egli, Hannes</creator><creator>Goosmann, Madeline M.</creator><creator>Monge Naldi, Arianne</creator><creator>Eckhard, Andreas H.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191101</creationdate><title>Immunolocalization of calcium sensing and transport proteins in the murine endolymphatic sac indicates calciostatic functions within the inner ear</title><author>Bächinger, David ; Egli, Hannes ; Goosmann, Madeline M. ; Monge Naldi, Arianne ; Eckhard, Andreas H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-3c7d11dac56e34aaa35bdf58e55423f00a17ffcf3d170bab2c056a125f309fa83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenosine triphosphatase</topic><topic>Animals</topic><topic>Auditory system</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Ca2+-transporting ATPase</topic><topic>Calcium (extracellular)</topic><topic>Calcium (reticular)</topic><topic>Calcium - metabolism</topic><topic>Calcium transport</topic><topic>Calcium-sensing receptors</topic><topic>Carrier proteins</topic><topic>Carrier Proteins - metabolism</topic><topic>Endolymph - metabolism</topic><topic>Endolymphatic Sac - metabolism</topic><topic>Endoplasmic reticulum</topic><topic>Epithelial cells</topic><topic>Epithelium</topic><topic>Epithelium - metabolism</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Human Genetics</topic><topic>Inner ear</topic><topic>Localization</topic><topic>Male</topic><topic>Meniere Disease - metabolism</topic><topic>Meniere's disease</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mitochondria</topic><topic>Molecular Medicine</topic><topic>Na+/Ca2+ exchanger</topic><topic>Paraffin</topic><topic>Proteins</topic><topic>Proteomics</topic><topic>Regular</topic><topic>Regular Article</topic><topic>Transient receptor potential proteins</topic><topic>Vestibular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bächinger, David</creatorcontrib><creatorcontrib>Egli, Hannes</creatorcontrib><creatorcontrib>Goosmann, Madeline M.</creatorcontrib><creatorcontrib>Monge Naldi, Arianne</creatorcontrib><creatorcontrib>Eckhard, Andreas H.</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell and tissue research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bächinger, David</au><au>Egli, Hannes</au><au>Goosmann, Madeline M.</au><au>Monge Naldi, Arianne</au><au>Eckhard, Andreas H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunolocalization of calcium sensing and transport proteins in the murine endolymphatic sac indicates calciostatic functions within the inner ear</atitle><jtitle>Cell and tissue research</jtitle><stitle>Cell Tissue Res</stitle><addtitle>Cell Tissue Res</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>378</volume><issue>2</issue><spage>163</spage><epage>173</epage><pages>163-173</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><abstract>An exceptionally low calcium (Ca
2+
) concentration in the inner ear endolymph ([Ca
2+
]
endolymph
) is crucial for proper auditory and vestibular function. The endolymphatic sac (ES) is believed to critically contribute to the maintenance of this low [Ca
2+
]
endolymph
. Here, we investigated the immunohistochemical localization of proteins that are presumably involved in the sensing and transport of extracellular Ca
2+
in the murine ES epithelium. Light microscopic and fluorescence immunolabeling in paraffin-embedded murine ES tissue sections (male C57BL/6 mice, 6–8 weeks old) demonstrated the presence of the calcium-sensing receptor CaSR, transient receptor potential cation channel subtypes TRPV5 and TRPV6, sarco/endoplasmic reticulum Ca
2+
-ATPases SERCA1 and SERCA2, Na
+
/Ca
2+
exchanger NCX2, and plasma membrane Ca
2+
ATPases PMCA1 and PMCA4 in ES epithelial cells. These proteins exhibited (i) membranous (apical or basolateral) or cytoplasmic localization patterns, (ii) a proximal-to-distal labeling gradient within the ES, and (iii) different distribution patterns among ES epithelial cell types (mitochondria-rich cells (MRCs) and ribosome-rich cells (RRCs)). Notably, in the inner ear membranous labyrinth, CaSR was exclusively localized in MRCs, suggesting a unique role of the ES epithelium in CaSR-mediated sensing and control of [Ca
2+
]
endolymph
. Structural loss of the distal ES, which is consistently observed in Meniere’s disease, may therefore critically disturb [Ca
2+
]
endolymph
and contribute to the pathogenesis of Meniere’s disease.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31338584</pmid><doi>10.1007/s00441-019-03062-2</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Cell and tissue research, 2019-11, Vol.378 (2), p.163-173 |
| issn | 0302-766X 1432-0878 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6815286 |
| source | MEDLINE; SpringerLink |
| subjects | Adenosine triphosphatase Animals Auditory system Biomedical and Life Sciences Biomedicine Ca2+-transporting ATPase Calcium (extracellular) Calcium (reticular) Calcium - metabolism Calcium transport Calcium-sensing receptors Carrier proteins Carrier Proteins - metabolism Endolymph - metabolism Endolymphatic Sac - metabolism Endoplasmic reticulum Epithelial cells Epithelium Epithelium - metabolism Ethylenediaminetetraacetic acid Human Genetics Inner ear Localization Male Meniere Disease - metabolism Meniere's disease Mice Mice, Inbred C57BL Mitochondria Molecular Medicine Na+/Ca2+ exchanger Paraffin Proteins Proteomics Regular Regular Article Transient receptor potential proteins Vestibular system |
| title | Immunolocalization of calcium sensing and transport proteins in the murine endolymphatic sac indicates calciostatic functions within the inner ear |
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