Ribosome collisions alter frameshifting at translational reprogramming motifs in bacterial mRNAs

Translational frameshifting involves the repositioning of ribosomes on their messages into decoding frames that differ from those dictated during initiation. Some messenger RNAs (mRNAs) contain motifs that promote deliberate frameshifting to regulate production of the encoded proteins. The mechanism...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-10, Vol.116 (43), p.21769-21779
Hauptverfasser:	Smith, Angela M., Costello, Michael S., Kettring, Andrew H., Wingo, Robert J., Moore, Sean D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Biological Sciences Collisions Dependence Elongation Escherichia coli - genetics Escherichia coli - metabolism Frameshift Mutation - genetics Frameshifting, Ribosomal - genetics Maintenance Messages mRNA Nucleic Acid Conformation Peptide Elongation Factors - metabolism PNAS Plus Protein Biosynthesis - genetics Proteins Reading Frames - genetics Ribosomal Proteins - metabolism Ribosomes Ribosomes - metabolism RNA, Messenger - genetics Stalling Stimulators Translation
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