Peculiarities of Uterine Cavity Biocenosis in Patients with Different Types of Endometrial Hyperproliferative Pathology
The peculiarities of the microbiocenosis of the uterine cavity in 184 patients of reproductive age with different types of endometrial hyperproliferative processes were studied: Group 1, n=60, non-atypical endometrial hyperplasia (NAEH); Group 2, n=62, endometrial polyps (EPs); Group 3, n=62, NAEH +...
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| Veröffentlicht in: | Journal of medicine and life 2019-07, Vol.12 (3), p.266-270 |
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| creator | Horban, Natalia Ye Vovk, Iraida B Lysiana, Tamara O Ponomariova, Inna H Zhulkevych, Igor V |
| description | The peculiarities of the microbiocenosis of the uterine cavity in 184 patients of reproductive age with different types of endometrial hyperproliferative processes were studied: Group 1, n=60, non-atypical endometrial hyperplasia (NAEH); Group 2, n=62, endometrial polyps (EPs); Group 3, n=62, NAEH + EPs. Correlation analysis of the degree of association between different biological media (uterus and genital tract) was carried out. Contamination of the uterine cavity by bacterial flora was diagnosed in all groups of patients examined. Anaerobic flora was about 30% while bacteria of the genus Bacteroides were the most common. Among aerobic organisms, representatives of the Enterobacteriaceae family and coccal flora are noted. The widest was the spectrum of isolated microorganisms in patients of group 2 (with endometrial polyps). A strong positive correlation was established between indices of genital tract contamination and the uterine cavity by coccal flora, Escherichia coli, and anaerobic organisms. The findings suggest dysbiotic changes and the presence of a chronic inflammatory focus in the endometrium, which pathogenetically substantiates the application of anti-inflammatory therapy in such patients. |
| doi_str_mv | 10.25122/jml-2019-0074 |
| format | Article |
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Mayborodi Str.;Tel.: + 38-050-547-16-92; E-mail: ngorban@i.ua ; I.Ya. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine ; Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine, Kiev, Ukraine</creatorcontrib><description>The peculiarities of the microbiocenosis of the uterine cavity in 184 patients of reproductive age with different types of endometrial hyperproliferative processes were studied: Group 1, n=60, non-atypical endometrial hyperplasia (NAEH); Group 2, n=62, endometrial polyps (EPs); Group 3, n=62, NAEH + EPs. Correlation analysis of the degree of association between different biological media (uterus and genital tract) was carried out. Contamination of the uterine cavity by bacterial flora was diagnosed in all groups of patients examined. Anaerobic flora was about 30% while bacteria of the genus Bacteroides were the most common. Among aerobic organisms, representatives of the Enterobacteriaceae family and coccal flora are noted. The widest was the spectrum of isolated microorganisms in patients of group 2 (with endometrial polyps). A strong positive correlation was established between indices of genital tract contamination and the uterine cavity by coccal flora, Escherichia coli, and anaerobic organisms. The findings suggest dysbiotic changes and the presence of a chronic inflammatory focus in the endometrium, which pathogenetically substantiates the application of anti-inflammatory therapy in such patients.</description><identifier>ISSN: 1844-122X</identifier><identifier>EISSN: 1844-3117</identifier><identifier>DOI: 10.25122/jml-2019-0074</identifier><identifier>PMID: 31666829</identifier><language>eng</language><publisher>Romania: Carol Daila University Foundation</publisher><subject>Adult ; Bacteria ; E coli ; Endometrium ; Endometrium - pathology ; Female ; Humans ; Hysterectomy ; Inflammatory diseases ; Microorganisms ; Middle Aged ; Original ; Pathology ; Polyps ; Polyps - pathology ; Uterine Neoplasms - pathology ; Uterus ; Uterus - microbiology ; Uterus - pathology</subject><ispartof>Journal of medicine and life, 2019-07, Vol.12 (3), p.266-270</ispartof><rights>Carol Davila University Press.</rights><rights>Copyright Carol Daila University Foundation Jul-Sep 2019</rights><rights>Carol Davila University Press 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3334-26d4cc70e729f1295bcaa78bd67fdd5a8fe4b87f09307203e6c7417d2c08f6823</citedby><cites>FETCH-LOGICAL-c3334-26d4cc70e729f1295bcaa78bd67fdd5a8fe4b87f09307203e6c7417d2c08f6823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814878/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814878/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31666829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horban, Natalia Ye</creatorcontrib><creatorcontrib>Vovk, Iraida B</creatorcontrib><creatorcontrib>Lysiana, Tamara O</creatorcontrib><creatorcontrib>Ponomariova, Inna H</creatorcontrib><creatorcontrib>Zhulkevych, Igor V</creatorcontrib><creatorcontrib>Horban Natalia, Senior Researcher at the Department of Family Planning, State Institution Institute of Pediatrics, Obstetrics and Gynecology named after Academician OM Lukianova NAMS of Ukraine, Ukraine, 04050, Kyiv, 8 P. Mayborodi Str.;Tel.: + 38-050-547-16-92; E-mail: ngorban@i.ua</creatorcontrib><creatorcontrib>I.Ya. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine</creatorcontrib><creatorcontrib>Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine, Kiev, Ukraine</creatorcontrib><title>Peculiarities of Uterine Cavity Biocenosis in Patients with Different Types of Endometrial Hyperproliferative Pathology</title><title>Journal of medicine and life</title><addtitle>J Med Life</addtitle><description>The peculiarities of the microbiocenosis of the uterine cavity in 184 patients of reproductive age with different types of endometrial hyperproliferative processes were studied: Group 1, n=60, non-atypical endometrial hyperplasia (NAEH); Group 2, n=62, endometrial polyps (EPs); Group 3, n=62, NAEH + EPs. Correlation analysis of the degree of association between different biological media (uterus and genital tract) was carried out. Contamination of the uterine cavity by bacterial flora was diagnosed in all groups of patients examined. Anaerobic flora was about 30% while bacteria of the genus Bacteroides were the most common. Among aerobic organisms, representatives of the Enterobacteriaceae family and coccal flora are noted. The widest was the spectrum of isolated microorganisms in patients of group 2 (with endometrial polyps). A strong positive correlation was established between indices of genital tract contamination and the uterine cavity by coccal flora, Escherichia coli, and anaerobic organisms. The findings suggest dysbiotic changes and the presence of a chronic inflammatory focus in the endometrium, which pathogenetically substantiates the application of anti-inflammatory therapy in such patients.</description><subject>Adult</subject><subject>Bacteria</subject><subject>E coli</subject><subject>Endometrium</subject><subject>Endometrium - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Inflammatory diseases</subject><subject>Microorganisms</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Pathology</subject><subject>Polyps</subject><subject>Polyps - pathology</subject><subject>Uterine Neoplasms - pathology</subject><subject>Uterus</subject><subject>Uterus - microbiology</subject><subject>Uterus - pathology</subject><issn>1844-122X</issn><issn>1844-3117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkc9PHCEcxUljU4312mND4sXLKL9mYC4m7WprE5N60KQ3wjLgsmGGFWbW7H_vd7urseXCF_i8F14eQl8oOWc1Zexi2ceKEdpWhEjxAR1RJUTFKZUH-xmgP4fopJQlgSXqpmn4J3TIKQyKtUfo-c7ZKQaTwxhcwcnjh9HlMDg8M-swbvD3kKwbUgkFhwHfGcCGseDnMC7wVfDeZTjj-81qp74eutS7MQcT8Q1c5lVOMQAFwrXb6hcppsfNZ_TRm1jcyX4_Rg8_ru9nN9Xt75-_Zt9uK8s5FxVrOmGtJE6y1lPW1nNrjFTzrpG-62qjvBNzJT1pOZGMcNdYKajsmCXKQ0J-jC53vqtp3rsOoozZRL3KoTd5o5MJ-t-XISz0Y1rrRlGhpAKDs71BTk-TK6PuQ7EuRjO4NBXNOCWS8pYIQE__Q5dpygPEA4o3rFaSSqDOd5TNqZTs_NtnKNF_a9VQq97Wqre1guDr-whv-GuJ_AX4vaCQ</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Horban, Natalia Ye</creator><creator>Vovk, Iraida B</creator><creator>Lysiana, Tamara O</creator><creator>Ponomariova, Inna H</creator><creator>Zhulkevych, Igor V</creator><general>Carol Daila University Foundation</general><general>Carol Davila University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201907</creationdate><title>Peculiarities of Uterine Cavity Biocenosis in Patients with Different Types of Endometrial Hyperproliferative Pathology</title><author>Horban, Natalia Ye ; Vovk, Iraida B ; Lysiana, Tamara O ; Ponomariova, Inna H ; Zhulkevych, Igor V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3334-26d4cc70e729f1295bcaa78bd67fdd5a8fe4b87f09307203e6c7417d2c08f6823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Bacteria</topic><topic>E coli</topic><topic>Endometrium</topic><topic>Endometrium - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Inflammatory diseases</topic><topic>Microorganisms</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Pathology</topic><topic>Polyps</topic><topic>Polyps - pathology</topic><topic>Uterine Neoplasms - pathology</topic><topic>Uterus</topic><topic>Uterus - microbiology</topic><topic>Uterus - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Horban, Natalia Ye</creatorcontrib><creatorcontrib>Vovk, Iraida B</creatorcontrib><creatorcontrib>Lysiana, Tamara O</creatorcontrib><creatorcontrib>Ponomariova, Inna H</creatorcontrib><creatorcontrib>Zhulkevych, Igor V</creatorcontrib><creatorcontrib>Horban Natalia, Senior Researcher at the Department of Family Planning, State Institution Institute of Pediatrics, Obstetrics and Gynecology named after Academician OM Lukianova NAMS of Ukraine, Ukraine, 04050, Kyiv, 8 P. 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Horbachevsky Ternopil National Medical University, Ternopil, Ukraine</aucorp><aucorp>Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine, Kiev, Ukraine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peculiarities of Uterine Cavity Biocenosis in Patients with Different Types of Endometrial Hyperproliferative Pathology</atitle><jtitle>Journal of medicine and life</jtitle><addtitle>J Med Life</addtitle><date>2019-07</date><risdate>2019</risdate><volume>12</volume><issue>3</issue><spage>266</spage><epage>270</epage><pages>266-270</pages><issn>1844-122X</issn><eissn>1844-3117</eissn><abstract>The peculiarities of the microbiocenosis of the uterine cavity in 184 patients of reproductive age with different types of endometrial hyperproliferative processes were studied: Group 1, n=60, non-atypical endometrial hyperplasia (NAEH); Group 2, n=62, endometrial polyps (EPs); Group 3, n=62, NAEH + EPs. Correlation analysis of the degree of association between different biological media (uterus and genital tract) was carried out. Contamination of the uterine cavity by bacterial flora was diagnosed in all groups of patients examined. Anaerobic flora was about 30% while bacteria of the genus Bacteroides were the most common. Among aerobic organisms, representatives of the Enterobacteriaceae family and coccal flora are noted. The widest was the spectrum of isolated microorganisms in patients of group 2 (with endometrial polyps). A strong positive correlation was established between indices of genital tract contamination and the uterine cavity by coccal flora, Escherichia coli, and anaerobic organisms. The findings suggest dysbiotic changes and the presence of a chronic inflammatory focus in the endometrium, which pathogenetically substantiates the application of anti-inflammatory therapy in such patients.</abstract><cop>Romania</cop><pub>Carol Daila University Foundation</pub><pmid>31666829</pmid><doi>10.25122/jml-2019-0074</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Bacteria E coli Endometrium Endometrium - pathology Female Humans Hysterectomy Inflammatory diseases Microorganisms Middle Aged Original Pathology Polyps Polyps - pathology Uterine Neoplasms - pathology Uterus Uterus - microbiology Uterus - pathology |
| title | Peculiarities of Uterine Cavity Biocenosis in Patients with Different Types of Endometrial Hyperproliferative Pathology |
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