Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial

AbstractObjectiveTo assess the efficacy of three months of antibiotic treatment compared with placebo in patients with chronic low back pain, previous disc herniation, and vertebral endplate changes (Modic changes).DesignDouble blind, parallel group, placebo controlled, multicentre trial.SettingHosp...

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Veröffentlicht in:	BMJ (Online) 2019-10, Vol.367, p.l5654-l5654
Hauptverfasser:	Bråten, Lars Christian Haugli, Rolfsen, Mads Peder, Espeland, Ansgar, Wigemyr, Monica, Aßmus, Jörg, Froholdt, Anne, Haugen, Anne Julsrud, Marchand, Gunn Hege, Kristoffersen, Per Martin, Lutro, Olav, Randen, Sigrun, Wilhelmsen, Maja, Winsvold, Bendik Slagsvold, Kadar, Thomas Istvan, Holmgard, Thor Einar, Vigeland, Maria Dehli, Vetti, Nils, Nygaard, Øystein Petter, Lie, Benedicte Alexandra, Hellum, Christian, Anke, Audny, Grotle, Margreth, Schistad, Elina Iordanova, Skouen, Jan Sture, Grøvle, Lars, Brox, Jens Ivar, Zwart, John-Anker, Storheim, Kjersti
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amoxicillin Amoxicillin - administration & dosage Amoxicillin - adverse effects Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Antibiotics Back pain Chronic Pain - diagnosis Chronic Pain - drug therapy Chronic Pain - etiology Disability Evaluation Double-Blind Method Double-blind studies Drug resistance Female Health sciences: 800 Helsefag: 800 Humans Intervertebral Disc Degeneration - complications Intervertebral Disc Displacement - complications Low back pain Low Back Pain - diagnosis Low Back Pain - drug therapy Low Back Pain - etiology Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - pathology Male Medical disciplines: 700 Medisinske Fag: 700 Middle Aged NMR Norway Nuclear magnetic resonance Older people Pain Measurement - methods Patients Penicillin Questionnaires Sensitivity analysis Surgery Systematic review Treatment Outcome VDP Vertebrae
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