PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer

Helicobacter pylori (H. pylori) infection is the main risk factor for gastric cancer. The role of antioxidant enzyme peroxiredoxin 2 (PRDX2) in gastric tumorigenesis remains unknown. In vitro (AGS and SNU-1 cell lines) and in vivo mouse models were utilized to investigate the role of PRDX2 in respon...

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Veröffentlicht in:	Redox biology 2020-01, Vol.28, p.101319, Article 101319
Hauptverfasser:	Wang, Sen, Chen, Zheng, Zhu, Shoumin, Lu, Heng, Peng, Dunfa, Soutto, Mohammed, Naz, Huma, Peek, Richard, Xu, Hao, Zaika, Alexander, Xu, Zekuan, El-Rifai, Wael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant response Apoptosis Biochemistry & Molecular Biology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cisplatin - pharmacology Gene Expression Regulation, Neoplastic - drug effects Helicobacter Infections - complications Helicobacter Infections - genetics Helicobacter Infections - metabolism Helicobacter pylori - pathogenicity Humans Infection Life Sciences & Biomedicine Mice Neoplasm Staging NF-κB Oxidative DNA damage Oxidative Stress Peroxiredoxins - genetics Peroxiredoxins - metabolism Prognosis Research Paper Science & Technology Stomach Neoplasms - etiology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Survival Analysis Up-Regulation
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