Complete Nucleotide Sequence of a Novel Plasmid Bearing the High-Level Tigecycline Resistance Gene tet (X4)
We reported the complete nucleotide sequence of a (X4)-carrying plasmid, pSTB20-1T, from a tigecycline-resistant isolate in China. Sequence analysis indicated that pSTB20-1T contains a hybrid plasmid backbone and a (X4)-containing multidrug resistance region, likely originated through recombination...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2019-11, Vol.63 (11) |
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| container_issue | 11 |
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| container_title | Antimicrobial agents and chemotherapy |
| container_volume | 63 |
| creator | Fang, Liang-Xing Chen, Chong Yu, Dong-Ling Sun, Ruan-Yang Cui, Chao-Yue Chen, Liang Liao, Xiao-Ping Liu, Ya-Hong Sun, Jian |
| description | We reported the complete nucleotide sequence of a
(X4)-carrying plasmid, pSTB20-1T, from a tigecycline-resistant
isolate in China. Sequence analysis indicated that pSTB20-1T contains a hybrid plasmid backbone and a
(X4)-containing multidrug resistance region, likely originated through recombination of multiple plasmids.
(X4) was flanked by two IS
, which may be responsible for
(X4) mobilization. The occurrence and transmission of this novel hybrid plasmid may exacerbate the spread of the clinically significant
(X4) gene. |
| doi_str_mv | 10.1128/AAC.01373-19 |
| format | Article |
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(X4)-carrying plasmid, pSTB20-1T, from a tigecycline-resistant
isolate in China. Sequence analysis indicated that pSTB20-1T contains a hybrid plasmid backbone and a
(X4)-containing multidrug resistance region, likely originated through recombination of multiple plasmids.
(X4) was flanked by two IS
, which may be responsible for
(X4) mobilization. The occurrence and transmission of this novel hybrid plasmid may exacerbate the spread of the clinically significant
(X4) gene.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.01373-19</identifier><identifier>PMID: 31481444</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Mechanisms of Resistance</subject><ispartof>Antimicrobial agents and chemotherapy, 2019-11, Vol.63 (11)</ispartof><rights>Copyright © 2019 American Society for Microbiology.</rights><rights>Copyright © 2019 American Society for Microbiology. 2019 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a418t-44a43bf66ea974bd42687e27a40a909d5b28689714bd3777508d2ce9c3000a7d3</citedby><cites>FETCH-LOGICAL-a418t-44a43bf66ea974bd42687e27a40a909d5b28689714bd3777508d2ce9c3000a7d3</cites><orcidid>0000-0002-4209-7555</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811429/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811429/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31481444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fang, Liang-Xing</creatorcontrib><creatorcontrib>Chen, Chong</creatorcontrib><creatorcontrib>Yu, Dong-Ling</creatorcontrib><creatorcontrib>Sun, Ruan-Yang</creatorcontrib><creatorcontrib>Cui, Chao-Yue</creatorcontrib><creatorcontrib>Chen, Liang</creatorcontrib><creatorcontrib>Liao, Xiao-Ping</creatorcontrib><creatorcontrib>Liu, Ya-Hong</creatorcontrib><creatorcontrib>Sun, Jian</creatorcontrib><title>Complete Nucleotide Sequence of a Novel Plasmid Bearing the High-Level Tigecycline Resistance Gene tet (X4)</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>We reported the complete nucleotide sequence of a
(X4)-carrying plasmid, pSTB20-1T, from a tigecycline-resistant
isolate in China. Sequence analysis indicated that pSTB20-1T contains a hybrid plasmid backbone and a
(X4)-containing multidrug resistance region, likely originated through recombination of multiple plasmids.
(X4) was flanked by two IS
, which may be responsible for
(X4) mobilization. The occurrence and transmission of this novel hybrid plasmid may exacerbate the spread of the clinically significant
(X4) gene.</description><subject>Mechanisms of Resistance</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kc1PGzEQxS1EBYFy67nyEaQutb1ef1yQ0qiFShGtWipxsxzvJDF41-nai8R_j9NQVA49jUbv6Tea9xB6R8k5pUx9nE5n54TWsq6o3kMTSrSqRKPFPpoQIkTFFeGH6CilO1L2RpMDdFhTrijnfILuZ7HbBMiAr0cXIGbfAv4Jv0foHeC4xBZfxwcI-HuwqfMt_gR28P0K5zXgK79aV3PYyjd-Be7RBd8D_gHJp2y3gEsoe4aMT2_52Vv0ZmlDgpPneYx-ffl8M7uq5t8uv86m88pyqnLFueX1YikEWC35ouVMKAlMWk6sJrptFkwJpSUtWi2lbIhqmQPt6vKglW19jC523M246KB10OfBBrMZfGeHRxOtN6-V3q_NKj4YoSjlTBfA6TNgiCWJlE3nk4MQbA9xTIYxxRtRsmTF-mFndUNMaYDlyxlKzLYfU_oxf_oxdEs-29lLmMzcxXHoSxL_877_940X8N_y6icHs5ch</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Fang, Liang-Xing</creator><creator>Chen, Chong</creator><creator>Yu, Dong-Ling</creator><creator>Sun, Ruan-Yang</creator><creator>Cui, Chao-Yue</creator><creator>Chen, Liang</creator><creator>Liao, Xiao-Ping</creator><creator>Liu, Ya-Hong</creator><creator>Sun, Jian</creator><general>American Society for Microbiology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4209-7555</orcidid></search><sort><creationdate>20191101</creationdate><title>Complete Nucleotide Sequence of a Novel Plasmid Bearing the High-Level Tigecycline Resistance Gene tet (X4)</title><author>Fang, Liang-Xing ; Chen, Chong ; Yu, Dong-Ling ; Sun, Ruan-Yang ; Cui, Chao-Yue ; Chen, Liang ; Liao, Xiao-Ping ; Liu, Ya-Hong ; Sun, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a418t-44a43bf66ea974bd42687e27a40a909d5b28689714bd3777508d2ce9c3000a7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Mechanisms of Resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Liang-Xing</creatorcontrib><creatorcontrib>Chen, Chong</creatorcontrib><creatorcontrib>Yu, Dong-Ling</creatorcontrib><creatorcontrib>Sun, Ruan-Yang</creatorcontrib><creatorcontrib>Cui, Chao-Yue</creatorcontrib><creatorcontrib>Chen, Liang</creatorcontrib><creatorcontrib>Liao, Xiao-Ping</creatorcontrib><creatorcontrib>Liu, Ya-Hong</creatorcontrib><creatorcontrib>Sun, Jian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Liang-Xing</au><au>Chen, Chong</au><au>Yu, Dong-Ling</au><au>Sun, Ruan-Yang</au><au>Cui, Chao-Yue</au><au>Chen, Liang</au><au>Liao, Xiao-Ping</au><au>Liu, Ya-Hong</au><au>Sun, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complete Nucleotide Sequence of a Novel Plasmid Bearing the High-Level Tigecycline Resistance Gene tet (X4)</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>63</volume><issue>11</issue><issn>0066-4804</issn><eissn>1098-6596</eissn><abstract>We reported the complete nucleotide sequence of a
(X4)-carrying plasmid, pSTB20-1T, from a tigecycline-resistant
isolate in China. Sequence analysis indicated that pSTB20-1T contains a hybrid plasmid backbone and a
(X4)-containing multidrug resistance region, likely originated through recombination of multiple plasmids.
(X4) was flanked by two IS
, which may be responsible for
(X4) mobilization. The occurrence and transmission of this novel hybrid plasmid may exacerbate the spread of the clinically significant
(X4) gene.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>31481444</pmid><doi>10.1128/AAC.01373-19</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-4209-7555</orcidid><oa>free_for_read</oa></addata></record> |
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| source | EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Mechanisms of Resistance |
| title | Complete Nucleotide Sequence of a Novel Plasmid Bearing the High-Level Tigecycline Resistance Gene tet (X4) |
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