Synergistic Meropenem-Tobramycin Combination Dosage Regimens against Clinical Hypermutable Pseudomonas aeruginosa at Simulated Epithelial Lining Fluid Concentrations in a Dynamic Biofilm Model

Exacerbations of chronic infections are a major treatment challenge in cystic fibrosis due to biofilm formation and hypermutation. We aimed to evaluate different dosage regimens of meropenem and tobramycin as monotherapies and in combination against hypermutable carbapenem-resistant A hypermutable i...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2019-11, Vol.63 (11)
Hauptverfasser:	Bilal, Hajira, Bergen, Phillip J, Kim, Tae Hwan, Chung, Seung Eun, Peleg, Anton Y, Oliver, Antonio, Nation, Roger L, Landersdorfer, Cornelia B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biofilms Meropenem Pharmacology Pseudomonas aeruginosa Pseudomonas Infections Tobramycin
Online-Zugang:	Volltext
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