Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation

The characteristics of DNA methylation changes that occur during neurogenesis in vivo remain unknown. We used whole-genome bisulfite sequencing to quantitate DNA cytosine modifications in differentiating neurons and their progenitors isolated from mouse brain at the peak of embryonic neurogenesis. L...

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Veröffentlicht in:	Science advances 2019-10, Vol.5 (10), p.eaax0080-eaax0080
Hauptverfasser:	Hahn, Maria A, Jin, Seung-Gi, Li, Arthur X, Liu, Jiancheng, Huang, Zhijun, Wu, Xiwei, Kim, Byung-Wook, Johnson, Jennifer, Bilbao, Adrienne-Denise V, Tao, Shu, Yim, Jacob A, Fong, Yuman, Goebbels, Sandra, Schwab, Markus H, Lu, Qiang, Pfeifer, Gerd P
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - metabolism Animals Base Sequence Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Differentiation Cell Line Cerebral Cortex - cytology DNA Methylation DNA-Binding Proteins - metabolism Enhancer Elements, Genetic - genetics Genetics Mice, Inbred C57BL Mice, Knockout Neurogenesis Neurons - cytology Neuropeptides - metabolism Nucleotide Motifs - genetics Oxidation-Reduction Protein Binding Proto-Oncogene Proteins - metabolism SciAdv r-articles
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