Serum levels of neopterin and interleukin-2 receptor in women with severe preeclampsia
Preeclampsia continues to be a major cause of maternal and perinatal mortality and morbidity worldwide. The etiopathogenesis of preeclampsia is not fully understood. Neopterin and interleukin‐2 (IL‐2) production reflects cellular immunity. Our purpose was to determine the levels of neopterin and int...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 2005, Vol.19 (2), p.36-39 |
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| creator | Kaleli, Ilknur Kaleli, Babur Demir, Melek Yildirim, Basak Cevahir, Nural Demir, Suleyman |
| description | Preeclampsia continues to be a major cause of maternal and perinatal mortality and morbidity worldwide. The etiopathogenesis of preeclampsia is not fully understood. Neopterin and interleukin‐2 (IL‐2) production reflects cellular immunity. Our purpose was to determine the levels of neopterin and interleukin‐2 receptor (IL‐2R) in pregnant women with severe preeclampsia, and assess the implications of these findings in the pathophysiology of preeclampsia. Fourteen women with preeclampsia were compared with 14 healthy pregnant women. Serum levels of neopterin were measured by an enzyme‐linked immunoassay (ELISA), and IL‐2R levels were determined by an immunoassay method with an Immulite analyzer. The levels of neopterin and IL‐2R were significantly higher in the preeclamptic subjects than in normotensive women (P |
| doi_str_mv | 10.1002/jcla.20053 |
| format | Article |
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The etiopathogenesis of preeclampsia is not fully understood. Neopterin and interleukin‐2 (IL‐2) production reflects cellular immunity. Our purpose was to determine the levels of neopterin and interleukin‐2 receptor (IL‐2R) in pregnant women with severe preeclampsia, and assess the implications of these findings in the pathophysiology of preeclampsia. Fourteen women with preeclampsia were compared with 14 healthy pregnant women. Serum levels of neopterin were measured by an enzyme‐linked immunoassay (ELISA), and IL‐2R levels were determined by an immunoassay method with an Immulite analyzer. The levels of neopterin and IL‐2R were significantly higher in the preeclamptic subjects than in normotensive women (P<0.05). There was a significant correlation between neopterin and IL‐2R. We found that serum neopterin and IL‐2R levels are increased in women with severe preeclampsia. The results of this study suggest that a T‐helper 1 (Th1) type immune mechanism is involved in the pathogenesis of preeclampsia. J. Clin. Lab. Anal. 19:36–39, 2005. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.20053</identifier><identifier>PMID: 15756710</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; IL-2R ; immunity ; Immunity, Cellular ; Interleukin-2 - blood ; neopterin ; Neopterin - blood ; Original ; Pre-Eclampsia - immunology ; preeclampsia ; Pregnancy</subject><ispartof>Journal of clinical laboratory analysis, 2005, Vol.19 (2), p.36-39</ispartof><rights>2005 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4883-52cb4fe13e922cfc7c82463fc768bd1ccd226f9b02a11ccda360d61522305c23</citedby><cites>FETCH-LOGICAL-c4883-52cb4fe13e922cfc7c82463fc768bd1ccd226f9b02a11ccda360d61522305c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807976/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807976/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,4009,27902,27903,27904,45553,45554,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15756710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaleli, Ilknur</creatorcontrib><creatorcontrib>Kaleli, Babur</creatorcontrib><creatorcontrib>Demir, Melek</creatorcontrib><creatorcontrib>Yildirim, Basak</creatorcontrib><creatorcontrib>Cevahir, Nural</creatorcontrib><creatorcontrib>Demir, Suleyman</creatorcontrib><title>Serum levels of neopterin and interleukin-2 receptor in women with severe preeclampsia</title><title>Journal of clinical laboratory analysis</title><addtitle>J. Clin. Lab. Anal</addtitle><description>Preeclampsia continues to be a major cause of maternal and perinatal mortality and morbidity worldwide. The etiopathogenesis of preeclampsia is not fully understood. Neopterin and interleukin‐2 (IL‐2) production reflects cellular immunity. Our purpose was to determine the levels of neopterin and interleukin‐2 receptor (IL‐2R) in pregnant women with severe preeclampsia, and assess the implications of these findings in the pathophysiology of preeclampsia. Fourteen women with preeclampsia were compared with 14 healthy pregnant women. Serum levels of neopterin were measured by an enzyme‐linked immunoassay (ELISA), and IL‐2R levels were determined by an immunoassay method with an Immulite analyzer. The levels of neopterin and IL‐2R were significantly higher in the preeclamptic subjects than in normotensive women (P<0.05). There was a significant correlation between neopterin and IL‐2R. We found that serum neopterin and IL‐2R levels are increased in women with severe preeclampsia. The results of this study suggest that a T‐helper 1 (Th1) type immune mechanism is involved in the pathogenesis of preeclampsia. J. Clin. Lab. Anal. 19:36–39, 2005. © 2005 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>IL-2R</subject><subject>immunity</subject><subject>Immunity, Cellular</subject><subject>Interleukin-2 - blood</subject><subject>neopterin</subject><subject>Neopterin - blood</subject><subject>Original</subject><subject>Pre-Eclampsia - immunology</subject><subject>preeclampsia</subject><subject>Pregnancy</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctuFDEQRS0EIkNgwwcgr0BC6lC224_eIEUDJEQjWCSCpeVxVxMn_YrdnZC_x5MZQthkY1fZ516VfQl5zeCAAfAPF751BxxAiidkwaAyBTdcPiULMEYXBpjYIy9SugAAUzH1nOwxqaXSDBbkxynGuaMtXmOb6NDQHodxwhh66vqahj7XLc6XoS84jehxnIaYj-nN0GFew3ROUxZHpGNEzJN0YwruJXnWuDbhq92-T86-fD5bHher70dfl4erwpfGiEJyvy4bZAIrzn3jtTe8VCIXyqxr5n3NuWqqNXDHNp0TCmrFJOcCpOdin3zc2o7zusPaYz9F19oxhs7FWzu4YP-_6cO5_TVcW2VAV1plg3c7gzhczZgm24XksW1d_oc5WV2WqgJV6Uy-fZRUWoIWRmTw_Rb0cUgpYnM_DgO7yctu8rJ3eWX4zcMH_EN3AWWAbYGb0OLtI1b2ZLk6_GtabDUhTfj7XuPiZZ5SaGl_fjuyBj6dLstSWCn-AOU0sLg</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Kaleli, Ilknur</creator><creator>Kaleli, Babur</creator><creator>Demir, Melek</creator><creator>Yildirim, Basak</creator><creator>Cevahir, Nural</creator><creator>Demir, Suleyman</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>2005</creationdate><title>Serum levels of neopterin and interleukin-2 receptor in women with severe preeclampsia</title><author>Kaleli, Ilknur ; Kaleli, Babur ; Demir, Melek ; Yildirim, Basak ; Cevahir, Nural ; Demir, Suleyman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4883-52cb4fe13e922cfc7c82463fc768bd1ccd226f9b02a11ccda360d61522305c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>IL-2R</topic><topic>immunity</topic><topic>Immunity, Cellular</topic><topic>Interleukin-2 - blood</topic><topic>neopterin</topic><topic>Neopterin - blood</topic><topic>Original</topic><topic>Pre-Eclampsia - immunology</topic><topic>preeclampsia</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaleli, Ilknur</creatorcontrib><creatorcontrib>Kaleli, Babur</creatorcontrib><creatorcontrib>Demir, Melek</creatorcontrib><creatorcontrib>Yildirim, Basak</creatorcontrib><creatorcontrib>Cevahir, Nural</creatorcontrib><creatorcontrib>Demir, Suleyman</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaleli, Ilknur</au><au>Kaleli, Babur</au><au>Demir, Melek</au><au>Yildirim, Basak</au><au>Cevahir, Nural</au><au>Demir, Suleyman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum levels of neopterin and interleukin-2 receptor in women with severe preeclampsia</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J. 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| subjects | Adult Enzyme-Linked Immunosorbent Assay Female Humans IL-2R immunity Immunity, Cellular Interleukin-2 - blood neopterin Neopterin - blood Original Pre-Eclampsia - immunology preeclampsia Pregnancy |
| title | Serum levels of neopterin and interleukin-2 receptor in women with severe preeclampsia |
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