Comparison of BNP and NT-proBNP assays in the approach to the emergency diagnosis of acute dyspnea
N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and BNP measurement could have a significant role in differentiating dyspnea between cardiac or pulmonary origin in the emergency room. The development of new and different commercial assays for these B‐type natriuretic peptides offers the possibi...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 2006, Vol.20 (6), p.227-232 |
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| creator | Sanz, M.P. Borque, L. Rus, A. Vicente, B. Ramírez, Y. Lasa, L. |
| description | N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and BNP measurement could have a significant role in differentiating dyspnea between cardiac or pulmonary origin in the emergency room. The development of new and different commercial assays for these B‐type natriuretic peptides offers the possibility of improving and simplifying their measurements but this could be defaulted due to the differences in methodology and the lack of assay standardization. We compared four available methods of measuring NT‐proBNP and BNP and evaluated their usefulness in diagnosing the causes of breathlessness in the emergency room. The correlation of BNP with different assays was strong with r>0.98 (P0.87. The area under the receiver‐operating characteristic curve (ROC) for BNP or NT‐proBNP for detecting any cardiac dysfunction was higher than 0.96 (95% CI). A BNP value of 116 pg/mL measurement with the Access BNP assay (Beckman Coulter Inc., Fullerton, CA), a BNP value of 79 pg/mL with Advia Centaur BNP assay (Bayer Diagnostics, Tarrytown, NY), and an NT‐proBNP level of 817 pg/mL in Elecsys NT‐proBNP assay (Roche Diagnostic, Mannheim, Germany), showed both high sensitivity (>92%) and high specificity (>93%). We have found that NT‐proBNP and BNP present similar diagnostic accuracies for the differential diagnosis of dyspnea. J. Clin. Lab. Anal. 20:227–232, 2006. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jcla.20146 |
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The development of new and different commercial assays for these B‐type natriuretic peptides offers the possibility of improving and simplifying their measurements but this could be defaulted due to the differences in methodology and the lack of assay standardization. We compared four available methods of measuring NT‐proBNP and BNP and evaluated their usefulness in diagnosing the causes of breathlessness in the emergency room. The correlation of BNP with different assays was strong with r>0.98 (P<0.0001). Comparison studiesbetween NT‐proBNP and BNP procedureswere in good agreement with r>0.87. The area under the receiver‐operating characteristic curve (ROC) for BNP or NT‐proBNP for detecting any cardiac dysfunction was higher than 0.96 (95% CI). A BNP value of 116 pg/mL measurement with the Access BNP assay (Beckman Coulter Inc., Fullerton, CA), a BNP value of 79 pg/mL with Advia Centaur BNP assay (Bayer Diagnostics, Tarrytown, NY), and an NT‐proBNP level of 817 pg/mL in Elecsys NT‐proBNP assay (Roche Diagnostic, Mannheim, Germany), showed both high sensitivity (>92%) and high specificity (>93%). We have found that NT‐proBNP and BNP present similar diagnostic accuracies for the differential diagnosis of dyspnea. J. Clin. Lab. 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Clin. Lab. Anal</addtitle><description>N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and BNP measurement could have a significant role in differentiating dyspnea between cardiac or pulmonary origin in the emergency room. The development of new and different commercial assays for these B‐type natriuretic peptides offers the possibility of improving and simplifying their measurements but this could be defaulted due to the differences in methodology and the lack of assay standardization. We compared four available methods of measuring NT‐proBNP and BNP and evaluated their usefulness in diagnosing the causes of breathlessness in the emergency room. The correlation of BNP with different assays was strong with r>0.98 (P<0.0001). Comparison studiesbetween NT‐proBNP and BNP procedureswere in good agreement with r>0.87. The area under the receiver‐operating characteristic curve (ROC) for BNP or NT‐proBNP for detecting any cardiac dysfunction was higher than 0.96 (95% CI). A BNP value of 116 pg/mL measurement with the Access BNP assay (Beckman Coulter Inc., Fullerton, CA), a BNP value of 79 pg/mL with Advia Centaur BNP assay (Bayer Diagnostics, Tarrytown, NY), and an NT‐proBNP level of 817 pg/mL in Elecsys NT‐proBNP assay (Roche Diagnostic, Mannheim, Germany), showed both high sensitivity (>92%) and high specificity (>93%). We have found that NT‐proBNP and BNP present similar diagnostic accuracies for the differential diagnosis of dyspnea. J. Clin. Lab. Anal. 20:227–232, 2006. © 2006 Wiley‐Liss, Inc.</description><subject>Aged</subject><subject>Blood Chemical Analysis - methods</subject><subject>Blood Chemical Analysis - statistics & numerical data</subject><subject>brain natriuretic peptides</subject><subject>Case-Control Studies</subject><subject>Diagnosis, Differential</subject><subject>dyspnea</subject><subject>Dyspnea - blood</subject><subject>Dyspnea - diagnosis</subject><subject>Dyspnea - etiology</subject><subject>Emergency Medical Services</subject><subject>Female</subject><subject>heart failure</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - diagnosis</subject><subject>Humans</subject><subject>Immunoassay - methods</subject><subject>Immunoassay - statistics & numerical data</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Original</subject><subject>Peptide Fragments - blood</subject><subject>Prospective Studies</subject><subject>respiratory disease method comparison</subject><subject>Respiratory Tract Diseases - blood</subject><subject>Respiratory Tract Diseases - complications</subject><subject>Respiratory Tract Diseases - diagnosis</subject><subject>Sensitivity and Specificity</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAURi1ERacDG34A8ooFUlrbiR_ZIHUiWlpGA0hFXVqOczPjksTBzgD592QeFNiwsq597vG1P4ReUnJOCWEXD7Yx54zQTDxBM0pylTDF-FM0I0rJRBGanqKzGB8IISqn4hk6pZJSnjEyQ2Xh294EF32HfY0Xq0_YdBVe3SV98PsqRjNG7Do8bACbfto2doMHv6-hhbCGzo64cmbd-ejiTmPsdgBcjbHvwDxHJ7VpIrw4rnP05erdXfE-WX68vikul4nljIlE1qxSKq8raSFnoiKQijQllmWU57YESWurcjM9zVJOTCp5xgmtuUhFWZtSpnP09uDtt2ULlYVuCKbRfXCtCaP2xul_Tzq30Wv_XQtFZMb5JHh9FAT_bQtx0K2LFprGdOC3ceKoVPk01By9OYA2-BgD1I-XUKJ3kehdJHofyQS_-nusP-gxgwmgB-CHa2D8j0rfFsvL39Lk0OPiAD8fe0z4qoWcvkbfr651cf_hc5EVC71IfwGCO6Yw</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Sanz, M.P.</creator><creator>Borque, L.</creator><creator>Rus, A.</creator><creator>Vicente, B.</creator><creator>Ramírez, Y.</creator><creator>Lasa, L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2006</creationdate><title>Comparison of BNP and NT-proBNP assays in the approach to the emergency diagnosis of acute dyspnea</title><author>Sanz, M.P. ; Borque, L. ; Rus, A. ; Vicente, B. ; Ramírez, Y. ; Lasa, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5226-7f2d889fd7ce926d0e36330c24159cbe71fc89a282c150a3754501f5636bfab73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Blood Chemical Analysis - methods</topic><topic>Blood Chemical Analysis - statistics & numerical data</topic><topic>brain natriuretic peptides</topic><topic>Case-Control Studies</topic><topic>Diagnosis, Differential</topic><topic>dyspnea</topic><topic>Dyspnea - blood</topic><topic>Dyspnea - diagnosis</topic><topic>Dyspnea - etiology</topic><topic>Emergency Medical Services</topic><topic>Female</topic><topic>heart failure</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - diagnosis</topic><topic>Humans</topic><topic>Immunoassay - methods</topic><topic>Immunoassay - statistics & numerical data</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Original</topic><topic>Peptide Fragments - blood</topic><topic>Prospective Studies</topic><topic>respiratory disease method comparison</topic><topic>Respiratory Tract Diseases - blood</topic><topic>Respiratory Tract Diseases - complications</topic><topic>Respiratory Tract Diseases - diagnosis</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanz, M.P.</creatorcontrib><creatorcontrib>Borque, L.</creatorcontrib><creatorcontrib>Rus, A.</creatorcontrib><creatorcontrib>Vicente, B.</creatorcontrib><creatorcontrib>Ramírez, Y.</creatorcontrib><creatorcontrib>Lasa, L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanz, M.P.</au><au>Borque, L.</au><au>Rus, A.</au><au>Vicente, B.</au><au>Ramírez, Y.</au><au>Lasa, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of BNP and NT-proBNP assays in the approach to the emergency diagnosis of acute dyspnea</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J. Clin. Lab. Anal</addtitle><date>2006</date><risdate>2006</risdate><volume>20</volume><issue>6</issue><spage>227</spage><epage>232</epage><pages>227-232</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and BNP measurement could have a significant role in differentiating dyspnea between cardiac or pulmonary origin in the emergency room. The development of new and different commercial assays for these B‐type natriuretic peptides offers the possibility of improving and simplifying their measurements but this could be defaulted due to the differences in methodology and the lack of assay standardization. We compared four available methods of measuring NT‐proBNP and BNP and evaluated their usefulness in diagnosing the causes of breathlessness in the emergency room. The correlation of BNP with different assays was strong with r>0.98 (P<0.0001). Comparison studiesbetween NT‐proBNP and BNP procedureswere in good agreement with r>0.87. The area under the receiver‐operating characteristic curve (ROC) for BNP or NT‐proBNP for detecting any cardiac dysfunction was higher than 0.96 (95% CI). A BNP value of 116 pg/mL measurement with the Access BNP assay (Beckman Coulter Inc., Fullerton, CA), a BNP value of 79 pg/mL with Advia Centaur BNP assay (Bayer Diagnostics, Tarrytown, NY), and an NT‐proBNP level of 817 pg/mL in Elecsys NT‐proBNP assay (Roche Diagnostic, Mannheim, Germany), showed both high sensitivity (>92%) and high specificity (>93%). We have found that NT‐proBNP and BNP present similar diagnostic accuracies for the differential diagnosis of dyspnea. J. Clin. Lab. Anal. 20:227–232, 2006. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17115420</pmid><doi>10.1002/jcla.20146</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Blood Chemical Analysis - methods Blood Chemical Analysis - statistics & numerical data brain natriuretic peptides Case-Control Studies Diagnosis, Differential dyspnea Dyspnea - blood Dyspnea - diagnosis Dyspnea - etiology Emergency Medical Services Female heart failure Heart Failure - blood Heart Failure - complications Heart Failure - diagnosis Humans Immunoassay - methods Immunoassay - statistics & numerical data Male Middle Aged Natriuretic Peptide, Brain - blood Original Peptide Fragments - blood Prospective Studies respiratory disease method comparison Respiratory Tract Diseases - blood Respiratory Tract Diseases - complications Respiratory Tract Diseases - diagnosis Sensitivity and Specificity |
| title | Comparison of BNP and NT-proBNP assays in the approach to the emergency diagnosis of acute dyspnea |
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