Phenotypically distinct anti-insulin B cells repopulate pancreatic islets after anti-CD20 treatment in NOD mice

Aims/hypothesis Autoreactive B cells escape immune tolerance and contribute to the pathogenesis of type 1 diabetes. While global B cell depletion is a successful therapy for autoimmune disease, the fate of autoreactive cells during this treatment in autoimmune diabetes is unknown. We aimed to identi...

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Veröffentlicht in:	Diabetologia 2019-11, Vol.62 (11), p.2052-2065
Hauptverfasser:	Boldison, Joanne, Da Rosa, Larissa C., Buckingham, Lucy, Davies, Joanne, Wen, Li, Wong, F. Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Antigens, CD20 - genetics Autoimmune diseases Autoimmunity B-Lymphocytes - cytology Beta cells CD19 antigen CD20 antigen Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - therapy Female Flow Cytometry Human Physiology Humans Immune Tolerance Immunological tolerance Immunotherapy Insulin Insulin - chemistry Internal Medicine Islets of Langerhans - cytology Islets of Langerhans - immunology Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred NOD Mice, Transgenic Pancreas Pancreas - immunology Transgenic mice
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