Physiological and druggable skipping of immunoglobulin variable exons in plasma cells

The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We recently demonstrated that aberrant Ig chains lacking variable (V) domains can be produced after nonsense-associated altered splicing (NAS) events. Remarkably, the expression...

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Veröffentlicht in:	Cellular & molecular immunology 2019-10, Vol.16 (10), p.810-819
Hauptverfasser:	Ashi, Mohamad Omar, Srour, Nivine, Lambert, Jean-Marie, Marchalot, Anne, Martin, Ophélie, Le Noir, Sandrine, Pinaud, Eric, Ayala, Maria Victoria, Sirac, Christophe, Saulière, Jérôme, Moreaux, Jérôme, Cogné, Michel, Delpy, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Antibodies Antisense oligonucleotides Apoptosis B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine Cell Differentiation Chromatin Endoplasmic reticulum Endoplasmic Reticulum Stress Exon skipping Exons - genetics Genetic Variation Genetics Heavy chains Immunoglobulin Heavy Chains - genetics Immunoglobulins Immunology Introns - genetics Life Sciences Life span Lymphocytes B Medical Microbiology Mice Mice, Inbred C57BL Microbiology Molecular modelling Nonsense Mediated mRNA Decay Plasma cells Plasma Cells - metabolism RNA Splicing Splicing Transcription V(D)J Recombination Vaccine
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