Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells
Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarray...
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| Veröffentlicht in: | Cellular & molecular immunology 2019-06, Vol.16 (6), p.580-589 |
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| creator | Wei, Yinxiang Zhang, Fanghui Zhang, Yu Wang, Xiaoqian Xing, Chen Guo, Jing Zhang, Hui Suo, Zhimin Li, Yan Wang, Jianli Wang, Renxi Cai, Zhijian |
| description | Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for molecules that are upregulated in IL-10-producing B cells and identified RNA-binding motif protein 47 (
Rbm47
) as a post-transcriptional regulator. Rbm47 was found to promote IL-10 production in B cells. We found that Rbm47 promotes the stability of IL-10 mRNA by binding to AU-rich elements in the 3′ untranslated region of
Il10
mRNA. In addition, we demonstrated that the overexpression of Rbm47 enabled B cells to facilitate Foxp3
+
regulator T-cell induction and reduce the severity of DSS-induced ulcerative colitis. Taken together, these results suggest that Rbm47 plays an important role in regulating IL-10 at the post-transcriptional level, thus promoting the regulatory functions of B cells. The findings presented in this study not only increase our understanding of the post-translational regulation of IL-10 in B cells but also identify a novel strategy for the potential application of Bregs. |
| doi_str_mv | 10.1038/s41423-018-0041-z |
| format | Article |
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Rbm47
) as a post-transcriptional regulator. Rbm47 was found to promote IL-10 production in B cells. We found that Rbm47 promotes the stability of IL-10 mRNA by binding to AU-rich elements in the 3′ untranslated region of
Il10
mRNA. In addition, we demonstrated that the overexpression of Rbm47 enabled B cells to facilitate Foxp3
+
regulator T-cell induction and reduce the severity of DSS-induced ulcerative colitis. Taken together, these results suggest that Rbm47 plays an important role in regulating IL-10 at the post-transcriptional level, thus promoting the regulatory functions of B cells. The findings presented in this study not only increase our understanding of the post-translational regulation of IL-10 in B cells but also identify a novel strategy for the potential application of Bregs.</description><identifier>ISSN: 1672-7681</identifier><identifier>EISSN: 2042-0226</identifier><identifier>DOI: 10.1038/s41423-018-0041-z</identifier><identifier>PMID: 29844590</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>3' Untranslated Regions - genetics ; Animals ; Antibodies ; B-Lymphocytes, Regulatory - immunology ; Biomedical and Life Sciences ; Biomedicine ; Colitis - immunology ; Dextran Sulfate ; Forkhead Transcription Factors ; Foxp3 protein ; Immune Tolerance ; Immunology ; Immunosuppression ; Interleukin 1 ; Interleukin 10 ; Interleukin-10 - genetics ; Interleukin-10 - metabolism ; Lymphocytes B ; Lymphocytes T ; Medical Microbiology ; Mice ; Mice, Inbred C57BL ; Microbiology ; mRNA stability ; Post-transcription ; Post-translation ; Protein Binding ; RNA Interference ; RNA-Binding Proteins - metabolism ; T-Lymphocytes, Regulatory - immunology ; Ulcerative colitis ; Up-Regulation ; Vaccine</subject><ispartof>Cellular & molecular immunology, 2019-06, Vol.16 (6), p.580-589</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-8904d0ef94be50cd754cd5cb07228b60ad222df871fa2378a82e9578310f6bc53</citedby><cites>FETCH-LOGICAL-c470t-8904d0ef94be50cd754cd5cb07228b60ad222df871fa2378a82e9578310f6bc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804925/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804925/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29844590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Yinxiang</creatorcontrib><creatorcontrib>Zhang, Fanghui</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Wang, Xiaoqian</creatorcontrib><creatorcontrib>Xing, Chen</creatorcontrib><creatorcontrib>Guo, Jing</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Suo, Zhimin</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Wang, Jianli</creatorcontrib><creatorcontrib>Wang, Renxi</creatorcontrib><creatorcontrib>Cai, Zhijian</creatorcontrib><title>Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells</title><title>Cellular & molecular immunology</title><addtitle>Cell Mol Immunol</addtitle><addtitle>Cell Mol Immunol</addtitle><description>Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for molecules that are upregulated in IL-10-producing B cells and identified RNA-binding motif protein 47 (
Rbm47
) as a post-transcriptional regulator. Rbm47 was found to promote IL-10 production in B cells. We found that Rbm47 promotes the stability of IL-10 mRNA by binding to AU-rich elements in the 3′ untranslated region of
Il10
mRNA. In addition, we demonstrated that the overexpression of Rbm47 enabled B cells to facilitate Foxp3
+
regulator T-cell induction and reduce the severity of DSS-induced ulcerative colitis. Taken together, these results suggest that Rbm47 plays an important role in regulating IL-10 at the post-transcriptional level, thus promoting the regulatory functions of B cells. The findings presented in this study not only increase our understanding of the post-translational regulation of IL-10 in B cells but also identify a novel strategy for the potential application of Bregs.</description><subject>3' Untranslated Regions - genetics</subject><subject>Animals</subject><subject>Antibodies</subject><subject>B-Lymphocytes, Regulatory - immunology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Colitis - immunology</subject><subject>Dextran Sulfate</subject><subject>Forkhead Transcription Factors</subject><subject>Foxp3 protein</subject><subject>Immune Tolerance</subject><subject>Immunology</subject><subject>Immunosuppression</subject><subject>Interleukin 1</subject><subject>Interleukin 10</subject><subject>Interleukin-10 - genetics</subject><subject>Interleukin-10 - metabolism</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Medical Microbiology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiology</subject><subject>mRNA stability</subject><subject>Post-transcription</subject><subject>Post-translation</subject><subject>Protein Binding</subject><subject>RNA Interference</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Ulcerative colitis</subject><subject>Up-Regulation</subject><subject>Vaccine</subject><issn>1672-7681</issn><issn>2042-0226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU-L1TAUxYMoznP0A7iRgBs30ZvbtEk3gg46M_BAEV2HNE3fdGibmtsOOJ_elDeOf8BVCOd3T3LuYey5hNcSCvOGlFRYCJBGACgpbh-wHYJCAYjVQ7aTlUahKyNP2BOia4DSKK0esxOsjVJlDTs2fI60iCW5iXzq56WPkxt4Cod1cEtM_EszKs3DEG7cEohf7oUEPqfYrn5juZva7TrGTV2uAu_HcZ0irfOcAtGGxI6_5z4MAz1ljzo3UHh2d56ybx8_fD27EPtP55dn7_bCKw2LMDWoFkJXqyaU4FtdKt-WvgGNaJoKXIuIbWe07BwW2jiDoS61KSR0VePL4pS9PfrOazOG1ocpBxzsnPrRpR82ut7-rUz9lT3EG1sZUDVuBq_uDFL8vgZa7NjTFsFNIa5k85I1qqqSMqMv_0Gv45ryEjOFqA3quqwzJY-UT5Eohe7-MxLs1qU9dmlzl3br0t7mmRd_prif-FVeBvAIUJamQ0i_n_6_609elavw</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Wei, Yinxiang</creator><creator>Zhang, Fanghui</creator><creator>Zhang, Yu</creator><creator>Wang, Xiaoqian</creator><creator>Xing, Chen</creator><creator>Guo, Jing</creator><creator>Zhang, Hui</creator><creator>Suo, Zhimin</creator><creator>Li, Yan</creator><creator>Wang, Jianli</creator><creator>Wang, Renxi</creator><creator>Cai, Zhijian</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190601</creationdate><title>Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells</title><author>Wei, Yinxiang ; Zhang, Fanghui ; Zhang, Yu ; Wang, Xiaoqian ; Xing, Chen ; Guo, Jing ; Zhang, Hui ; Suo, Zhimin ; Li, Yan ; Wang, Jianli ; Wang, Renxi ; Cai, Zhijian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-8904d0ef94be50cd754cd5cb07228b60ad222df871fa2378a82e9578310f6bc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>3' Untranslated Regions - genetics</topic><topic>Animals</topic><topic>Antibodies</topic><topic>B-Lymphocytes, Regulatory - immunology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Colitis - immunology</topic><topic>Dextran Sulfate</topic><topic>Forkhead Transcription Factors</topic><topic>Foxp3 protein</topic><topic>Immune Tolerance</topic><topic>Immunology</topic><topic>Immunosuppression</topic><topic>Interleukin 1</topic><topic>Interleukin 10</topic><topic>Interleukin-10 - genetics</topic><topic>Interleukin-10 - metabolism</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Medical Microbiology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiology</topic><topic>mRNA stability</topic><topic>Post-transcription</topic><topic>Post-translation</topic><topic>Protein Binding</topic><topic>RNA Interference</topic><topic>RNA-Binding Proteins - metabolism</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Ulcerative colitis</topic><topic>Up-Regulation</topic><topic>Vaccine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Yinxiang</creatorcontrib><creatorcontrib>Zhang, Fanghui</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Wang, Xiaoqian</creatorcontrib><creatorcontrib>Xing, Chen</creatorcontrib><creatorcontrib>Guo, Jing</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Suo, Zhimin</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Wang, Jianli</creatorcontrib><creatorcontrib>Wang, Renxi</creatorcontrib><creatorcontrib>Cai, Zhijian</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular & molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Yinxiang</au><au>Zhang, Fanghui</au><au>Zhang, Yu</au><au>Wang, Xiaoqian</au><au>Xing, Chen</au><au>Guo, Jing</au><au>Zhang, Hui</au><au>Suo, Zhimin</au><au>Li, Yan</au><au>Wang, Jianli</au><au>Wang, Renxi</au><au>Cai, Zhijian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells</atitle><jtitle>Cellular & molecular immunology</jtitle><stitle>Cell Mol Immunol</stitle><addtitle>Cell Mol Immunol</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>16</volume><issue>6</issue><spage>580</spage><epage>589</epage><pages>580-589</pages><issn>1672-7681</issn><eissn>2042-0226</eissn><abstract>Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for molecules that are upregulated in IL-10-producing B cells and identified RNA-binding motif protein 47 (
Rbm47
) as a post-transcriptional regulator. Rbm47 was found to promote IL-10 production in B cells. We found that Rbm47 promotes the stability of IL-10 mRNA by binding to AU-rich elements in the 3′ untranslated region of
Il10
mRNA. In addition, we demonstrated that the overexpression of Rbm47 enabled B cells to facilitate Foxp3
+
regulator T-cell induction and reduce the severity of DSS-induced ulcerative colitis. Taken together, these results suggest that Rbm47 plays an important role in regulating IL-10 at the post-transcriptional level, thus promoting the regulatory functions of B cells. The findings presented in this study not only increase our understanding of the post-translational regulation of IL-10 in B cells but also identify a novel strategy for the potential application of Bregs.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29844590</pmid><doi>10.1038/s41423-018-0041-z</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3' Untranslated Regions - genetics Animals Antibodies B-Lymphocytes, Regulatory - immunology Biomedical and Life Sciences Biomedicine Colitis - immunology Dextran Sulfate Forkhead Transcription Factors Foxp3 protein Immune Tolerance Immunology Immunosuppression Interleukin 1 Interleukin 10 Interleukin-10 - genetics Interleukin-10 - metabolism Lymphocytes B Lymphocytes T Medical Microbiology Mice Mice, Inbred C57BL Microbiology mRNA stability Post-transcription Post-translation Protein Binding RNA Interference RNA-Binding Proteins - metabolism T-Lymphocytes, Regulatory - immunology Ulcerative colitis Up-Regulation Vaccine |
| title | Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells |
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