Losartan does not inhibit cigarette smoke-induced lung inflammation in mice

Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease largely caused by cigarette smoking (CS) and is characterized by lung inflammation and airflow limitation that is not fully reversible. Approximately 50% of people with COPD die of a cardiovascular comorbidity and current pha...

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Veröffentlicht in:	Scientific reports 2019-10, Vol.9 (1), p.15053-11, Article 15053
Hauptverfasser:	Hepworth, M. L., Passey, S. L., Seow, H. J., Vlahos, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	38 64 64/60 692/420/256/2515 692/699/1785/4037 Alveoli Angiotensin AT1 receptors Angiotensin II Animals Bronchoalveolar Lavage Fluid Bronchus Cardiovascular diseases Cardiovascular system Chemokines Chemokines - genetics Chemokines - metabolism Chronic obstructive pulmonary disease Cigarette smoke Cigarette smoking Cigarette Smoking - adverse effects Cigarettes Drinking Behavior - drug effects Feeding Behavior - drug effects Gene expression Gene Expression Regulation - drug effects Humanities and Social Sciences Hypertension Inflammation Inflammation Mediators - metabolism Interleukin 6 Leukocytes (neutrophilic) Losartan - pharmacology Lung - drug effects Lung - pathology Lung diseases Macrophages Male Mice, Inbred BALB C multidisciplinary Obstructive lung disease Organ Size - drug effects Pneumonia - etiology Pneumonia - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) Tumor necrosis factor-α
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