Fc Gamma Receptor Polymorphisms Modulated the Vaccine Effect on HIV-1 Risk in the HVTN 505 HIV Vaccine Trial

HIV Vaccine Trials Network (HVTN) 505 was a phase 2b efficacy trial of a DNA/recombinant adenovirus 5 (rAd5) HIV vaccine regimen. Although the trial was stopped early for lack of overall efficacy, later correlates of risk and sieve analyses generated the hypothesis that the DNA/rAd5 vaccine regimen...

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Veröffentlicht in:	Journal of virology 2019-11, Vol.93 (21)
Hauptverfasser:	Li, Shuying S, Gilbert, Peter B, Carpp, Lindsay N, Pyo, Chul-Woo, Janes, Holly, Fong, Youyi, Shen, Xiaoying, Neidich, Scott D, Goodman, Derrick, deCamp, Allan, Cohen, Kristen W, Ferrari, Guido, Hammer, Scott M, Sobieszczyk, Magdalena E, Mulligan, Mark J, Buchbinder, Susan P, Keefer, Michael C, DeJesus, Edwin, Novak, Richard M, Frank, Ian, McElrath, M Juliana, Tomaras, Georgia D, Geraghty, Daniel E, Peng, Xinxia
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - virology Case-Control Studies CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - virology Clinical Trials, Phase II as Topic env Gene Products, Human Immunodeficiency Virus - immunology Genetic Vectors - administration & dosage HIV Infections - epidemiology HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV Seropositivity HIV-1 - genetics HIV-1 - immunology Humans Incidence Phagocytosis Polymorphism, Single Nucleotide Receptors, IgG - genetics United States - epidemiology Vaccination Vaccines and Antiviral Agents Vaccines, DNA - administration & dosage
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