Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study
Objective To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life. Design Prospective study of infants in the New Hampshire Birth Cohort Study (NHBCS). Settings Rural New Hampshire, USA. Population or sample Two...
Gespeichert in:
| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2020-01, Vol.127 (2), p.217-227 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 227 |
|---|---|
| container_issue | 2 |
| container_start_page | 217 |
| container_title | BJOG : an international journal of obstetrics and gynaecology |
| container_volume | 127 |
| creator | Coker, MO Hoen, AG Dade, E Lundgren, S Li, Z Wong, AD Zens, MS Palys, TJ Morrison, HG Sogin, ML Baker, ER Karagas, MR Madan, JC |
| description | Objective
To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.
Design
Prospective study of infants in the New Hampshire Birth Cohort Study (NHBCS).
Settings
Rural New Hampshire, USA.
Population or sample
Two hundred and sixty‐six full‐term infants from the NHBCS.
Methods
Intrapartum antibiotic use during labour and delivery was ed from medical records. Faecal samples collected at 6 weeks and 1 year of age were characterised by 16S rRNA sequencing, and metagenomics analysis in a subset of samples.
Exposures
Maternal exposure to antibiotics during labour and delivery.
Main outcome measure
Taxonomic and functional profiles of faecal samples.
Results
Infant exposure to intrapartum antibiotics, particularly to two or more antibiotic classes, was independently associated with lower microbial diversity scores as well as a unique bacterial community at 6 weeks (GUnifrac, P = 0.02). At 1 year, infants in the penicillin‐only group had significantly lower α diversity scores than infants not exposed to intrapartum antibiotics. Within the first year of life, intrapartum exposure to penicillins was related to a significantly lower increase in several taxa including Bacteroides, use of cephalosporins was associated with a significantly lower rise over time in Bifidobacterium and infants in the multi‐class group experienced a significantly higher increase in Veillonella dispar.
Conclusions
Our findings suggest that intrapartum antibiotics alter the developmental trajectory of the infant gut microbiome, and specific antibiotic types may impact community composition, diversity and keystone immune training taxa.
Tweetable
Class of intrapartum antibiotics administered during delivery relates to maturation of infant gut microbiota.
Tweetable
Class of intrapartum antibiotics administered during delivery relates to maturation of infant gut microbiota. |
| doi_str_mv | 10.1111/1471-0528.15799 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6803026</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2212716703</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4399-bebbaf063dc1f6ed99468ed29eb5b5d97c9cf5ca4780ff4f0a6dd658f0a5501a3</originalsourceid><addsrcrecordid>eNqFkc1v3CAQxVHVqkmTnnuLOPbiZLANNjlESqN-KlIOTc8I4yFLZBsHcNr974uz6ao9lQuj4ffeAI-QdwxOWV5nrG5YAbxsTxlvpHxBDvedl081FFCV7QF5E-M9ABMlVK_JQcUABGvgkPz6PqNx1hlqBh0j9Za6KQU965CWkeopuc755EykAQedMNLk6ajTEnRyfloFaYNZZDNL75ZER2eCX0X6nGo6Bx_ziOQekRq_8SHRmJZ-e0xeWT1EfPu8H5Efnz7eXn0prm8-f726vC5MXUlZdNh12oKoesOswF7KWrTYlxI73vFeNkYay42umxasrS1o0feCt7ngHJiujsjFzndeuhF7g-vrBjUHN-qwVV479e_J5Dbqzj8q0UIFpcgG758Ngn9YMCY1umhwGPSEfomqLFnZMNFAldGzHZo_IMaAdj-GgVrzUms6ak1HPeWVFSd_327P_wkoA3wH_HQDbv_npz58u9kZ_wZoNqRf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2212716703</pqid></control><display><type>article</type><title>Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Coker, MO ; Hoen, AG ; Dade, E ; Lundgren, S ; Li, Z ; Wong, AD ; Zens, MS ; Palys, TJ ; Morrison, HG ; Sogin, ML ; Baker, ER ; Karagas, MR ; Madan, JC</creator><creatorcontrib>Coker, MO ; Hoen, AG ; Dade, E ; Lundgren, S ; Li, Z ; Wong, AD ; Zens, MS ; Palys, TJ ; Morrison, HG ; Sogin, ML ; Baker, ER ; Karagas, MR ; Madan, JC</creatorcontrib><description>Objective
To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.
Design
Prospective study of infants in the New Hampshire Birth Cohort Study (NHBCS).
Settings
Rural New Hampshire, USA.
Population or sample
Two hundred and sixty‐six full‐term infants from the NHBCS.
Methods
Intrapartum antibiotic use during labour and delivery was ed from medical records. Faecal samples collected at 6 weeks and 1 year of age were characterised by 16S rRNA sequencing, and metagenomics analysis in a subset of samples.
Exposures
Maternal exposure to antibiotics during labour and delivery.
Main outcome measure
Taxonomic and functional profiles of faecal samples.
Results
Infant exposure to intrapartum antibiotics, particularly to two or more antibiotic classes, was independently associated with lower microbial diversity scores as well as a unique bacterial community at 6 weeks (GUnifrac, P = 0.02). At 1 year, infants in the penicillin‐only group had significantly lower α diversity scores than infants not exposed to intrapartum antibiotics. Within the first year of life, intrapartum exposure to penicillins was related to a significantly lower increase in several taxa including Bacteroides, use of cephalosporins was associated with a significantly lower rise over time in Bifidobacterium and infants in the multi‐class group experienced a significantly higher increase in Veillonella dispar.
Conclusions
Our findings suggest that intrapartum antibiotics alter the developmental trajectory of the infant gut microbiome, and specific antibiotic types may impact community composition, diversity and keystone immune training taxa.
Tweetable
Class of intrapartum antibiotics administered during delivery relates to maturation of infant gut microbiota.
Tweetable
Class of intrapartum antibiotics administered during delivery relates to maturation of infant gut microbiota.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/1471-0528.15799</identifier><identifier>PMID: 31006170</identifier><language>eng</language><publisher>England</publisher><subject>Antibiotic Prophylaxis ; Bacteroides - growth & development ; Bacteroidetes ; beta-Lactamases ; Bifidobacterium ; Feces - microbiology ; Female ; Gastrointestinal Microbiome - drug effects ; Gut ; Humans ; infant ; Infant, Newborn ; intestinal microbiota ; intrapartum antibiotics ; Lactobacillus ; Maternal Exposure ; Mothers ; neonate ; Pregnancy ; Prospective Studies ; RNA, Ribosomal, 16S ; Sequence Analysis, RNA ; Term Birth ; Vagina - microbiology</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2020-01, Vol.127 (2), p.217-227</ispartof><rights>2019 Royal College of Obstetricians and Gynaecologists</rights><rights>2019 Royal College of Obstetricians and Gynaecologists.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4399-bebbaf063dc1f6ed99468ed29eb5b5d97c9cf5ca4780ff4f0a6dd658f0a5501a3</citedby><cites>FETCH-LOGICAL-c4399-bebbaf063dc1f6ed99468ed29eb5b5d97c9cf5ca4780ff4f0a6dd658f0a5501a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1471-0528.15799$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1471-0528.15799$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31006170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coker, MO</creatorcontrib><creatorcontrib>Hoen, AG</creatorcontrib><creatorcontrib>Dade, E</creatorcontrib><creatorcontrib>Lundgren, S</creatorcontrib><creatorcontrib>Li, Z</creatorcontrib><creatorcontrib>Wong, AD</creatorcontrib><creatorcontrib>Zens, MS</creatorcontrib><creatorcontrib>Palys, TJ</creatorcontrib><creatorcontrib>Morrison, HG</creatorcontrib><creatorcontrib>Sogin, ML</creatorcontrib><creatorcontrib>Baker, ER</creatorcontrib><creatorcontrib>Karagas, MR</creatorcontrib><creatorcontrib>Madan, JC</creatorcontrib><title>Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Objective
To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.
Design
Prospective study of infants in the New Hampshire Birth Cohort Study (NHBCS).
Settings
Rural New Hampshire, USA.
Population or sample
Two hundred and sixty‐six full‐term infants from the NHBCS.
Methods
Intrapartum antibiotic use during labour and delivery was ed from medical records. Faecal samples collected at 6 weeks and 1 year of age were characterised by 16S rRNA sequencing, and metagenomics analysis in a subset of samples.
Exposures
Maternal exposure to antibiotics during labour and delivery.
Main outcome measure
Taxonomic and functional profiles of faecal samples.
Results
Infant exposure to intrapartum antibiotics, particularly to two or more antibiotic classes, was independently associated with lower microbial diversity scores as well as a unique bacterial community at 6 weeks (GUnifrac, P = 0.02). At 1 year, infants in the penicillin‐only group had significantly lower α diversity scores than infants not exposed to intrapartum antibiotics. Within the first year of life, intrapartum exposure to penicillins was related to a significantly lower increase in several taxa including Bacteroides, use of cephalosporins was associated with a significantly lower rise over time in Bifidobacterium and infants in the multi‐class group experienced a significantly higher increase in Veillonella dispar.
Conclusions
Our findings suggest that intrapartum antibiotics alter the developmental trajectory of the infant gut microbiome, and specific antibiotic types may impact community composition, diversity and keystone immune training taxa.
Tweetable
Class of intrapartum antibiotics administered during delivery relates to maturation of infant gut microbiota.
Tweetable
Class of intrapartum antibiotics administered during delivery relates to maturation of infant gut microbiota.</description><subject>Antibiotic Prophylaxis</subject><subject>Bacteroides - growth & development</subject><subject>Bacteroidetes</subject><subject>beta-Lactamases</subject><subject>Bifidobacterium</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Gut</subject><subject>Humans</subject><subject>infant</subject><subject>Infant, Newborn</subject><subject>intestinal microbiota</subject><subject>intrapartum antibiotics</subject><subject>Lactobacillus</subject><subject>Maternal Exposure</subject><subject>Mothers</subject><subject>neonate</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>RNA, Ribosomal, 16S</subject><subject>Sequence Analysis, RNA</subject><subject>Term Birth</subject><subject>Vagina - microbiology</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v3CAQxVHVqkmTnnuLOPbiZLANNjlESqN-KlIOTc8I4yFLZBsHcNr974uz6ao9lQuj4ffeAI-QdwxOWV5nrG5YAbxsTxlvpHxBDvedl081FFCV7QF5E-M9ABMlVK_JQcUABGvgkPz6PqNx1hlqBh0j9Za6KQU965CWkeopuc755EykAQedMNLk6ajTEnRyfloFaYNZZDNL75ZER2eCX0X6nGo6Bx_ziOQekRq_8SHRmJZ-e0xeWT1EfPu8H5Efnz7eXn0prm8-f726vC5MXUlZdNh12oKoesOswF7KWrTYlxI73vFeNkYay42umxasrS1o0feCt7ngHJiujsjFzndeuhF7g-vrBjUHN-qwVV479e_J5Dbqzj8q0UIFpcgG758Ngn9YMCY1umhwGPSEfomqLFnZMNFAldGzHZo_IMaAdj-GgVrzUms6ak1HPeWVFSd_327P_wkoA3wH_HQDbv_npz58u9kZ_wZoNqRf</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Coker, MO</creator><creator>Hoen, AG</creator><creator>Dade, E</creator><creator>Lundgren, S</creator><creator>Li, Z</creator><creator>Wong, AD</creator><creator>Zens, MS</creator><creator>Palys, TJ</creator><creator>Morrison, HG</creator><creator>Sogin, ML</creator><creator>Baker, ER</creator><creator>Karagas, MR</creator><creator>Madan, JC</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202001</creationdate><title>Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study</title><author>Coker, MO ; Hoen, AG ; Dade, E ; Lundgren, S ; Li, Z ; Wong, AD ; Zens, MS ; Palys, TJ ; Morrison, HG ; Sogin, ML ; Baker, ER ; Karagas, MR ; Madan, JC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4399-bebbaf063dc1f6ed99468ed29eb5b5d97c9cf5ca4780ff4f0a6dd658f0a5501a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibiotic Prophylaxis</topic><topic>Bacteroides - growth & development</topic><topic>Bacteroidetes</topic><topic>beta-Lactamases</topic><topic>Bifidobacterium</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Gut</topic><topic>Humans</topic><topic>infant</topic><topic>Infant, Newborn</topic><topic>intestinal microbiota</topic><topic>intrapartum antibiotics</topic><topic>Lactobacillus</topic><topic>Maternal Exposure</topic><topic>Mothers</topic><topic>neonate</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>RNA, Ribosomal, 16S</topic><topic>Sequence Analysis, RNA</topic><topic>Term Birth</topic><topic>Vagina - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coker, MO</creatorcontrib><creatorcontrib>Hoen, AG</creatorcontrib><creatorcontrib>Dade, E</creatorcontrib><creatorcontrib>Lundgren, S</creatorcontrib><creatorcontrib>Li, Z</creatorcontrib><creatorcontrib>Wong, AD</creatorcontrib><creatorcontrib>Zens, MS</creatorcontrib><creatorcontrib>Palys, TJ</creatorcontrib><creatorcontrib>Morrison, HG</creatorcontrib><creatorcontrib>Sogin, ML</creatorcontrib><creatorcontrib>Baker, ER</creatorcontrib><creatorcontrib>Karagas, MR</creatorcontrib><creatorcontrib>Madan, JC</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coker, MO</au><au>Hoen, AG</au><au>Dade, E</au><au>Lundgren, S</au><au>Li, Z</au><au>Wong, AD</au><au>Zens, MS</au><au>Palys, TJ</au><au>Morrison, HG</au><au>Sogin, ML</au><au>Baker, ER</au><au>Karagas, MR</au><au>Madan, JC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2020-01</date><risdate>2020</risdate><volume>127</volume><issue>2</issue><spage>217</spage><epage>227</epage><pages>217-227</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><abstract>Objective
To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.
Design
Prospective study of infants in the New Hampshire Birth Cohort Study (NHBCS).
Settings
Rural New Hampshire, USA.
Population or sample
Two hundred and sixty‐six full‐term infants from the NHBCS.
Methods
Intrapartum antibiotic use during labour and delivery was ed from medical records. Faecal samples collected at 6 weeks and 1 year of age were characterised by 16S rRNA sequencing, and metagenomics analysis in a subset of samples.
Exposures
Maternal exposure to antibiotics during labour and delivery.
Main outcome measure
Taxonomic and functional profiles of faecal samples.
Results
Infant exposure to intrapartum antibiotics, particularly to two or more antibiotic classes, was independently associated with lower microbial diversity scores as well as a unique bacterial community at 6 weeks (GUnifrac, P = 0.02). At 1 year, infants in the penicillin‐only group had significantly lower α diversity scores than infants not exposed to intrapartum antibiotics. Within the first year of life, intrapartum exposure to penicillins was related to a significantly lower increase in several taxa including Bacteroides, use of cephalosporins was associated with a significantly lower rise over time in Bifidobacterium and infants in the multi‐class group experienced a significantly higher increase in Veillonella dispar.
Conclusions
Our findings suggest that intrapartum antibiotics alter the developmental trajectory of the infant gut microbiome, and specific antibiotic types may impact community composition, diversity and keystone immune training taxa.
Tweetable
Class of intrapartum antibiotics administered during delivery relates to maturation of infant gut microbiota.
Tweetable
Class of intrapartum antibiotics administered during delivery relates to maturation of infant gut microbiota.</abstract><cop>England</cop><pmid>31006170</pmid><doi>10.1111/1471-0528.15799</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2020-01, Vol.127 (2), p.217-227 |
| issn | 1470-0328 1471-0528 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6803026 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Antibiotic Prophylaxis Bacteroides - growth & development Bacteroidetes beta-Lactamases Bifidobacterium Feces - microbiology Female Gastrointestinal Microbiome - drug effects Gut Humans infant Infant, Newborn intestinal microbiota intrapartum antibiotics Lactobacillus Maternal Exposure Mothers neonate Pregnancy Prospective Studies RNA, Ribosomal, 16S Sequence Analysis, RNA Term Birth Vagina - microbiology |
| title | Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T04%3A28%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Specific%20class%20of%20intrapartum%20antibiotics%20relates%20to%20maturation%20of%20the%20infant%20gut%20microbiota:%20a%20prospective%20cohort%20study&rft.jtitle=BJOG%20:%20an%20international%20journal%20of%20obstetrics%20and%20gynaecology&rft.au=Coker,%20MO&rft.date=2020-01&rft.volume=127&rft.issue=2&rft.spage=217&rft.epage=227&rft.pages=217-227&rft.issn=1470-0328&rft.eissn=1471-0528&rft_id=info:doi/10.1111/1471-0528.15799&rft_dat=%3Cproquest_pubme%3E2212716703%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2212716703&rft_id=info:pmid/31006170&rfr_iscdi=true |