IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes: JAKinibs suppress the interferon response in RA-FLSs

Rheumatoid arthritis (RA) is an autoimmune disease characterized by persistent synovial inflammation. The major drivers of synovial inflammation are cytokines and chemokines. Among these molecules, TNF activates fibroblast-like synoviocytes (FLSs), which leads to the production of inflammatory media...

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Veröffentlicht in:	Experimental & molecular medicine 2019-07, Vol.51 (7), p.1-11
Hauptverfasser:	Bonelli, Michael, Dalwigk, Karolina, Platzer, Alexander, Olmos Calvo, Isabel, Hayer, Silvia, Niederreiter, Birgit, Holinka, Johannes, Sevelda, Florian, Pap, Thomas, Steiner, Günter, Superti-Furga, Giulio, Smolen, Josef S., Kiener, Hans P., Karonitsch, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/51 13/95 42/89 45/90 631/250/127/1212 631/250/256/2515 64/110 64/60 96/109 Animals Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Azetidines - therapeutic use Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Female Gene Expression Humans Inflammation Interferon Regulatory Factor-1 - genetics Interferon Regulatory Factor-1 - metabolism Interferons - genetics Interferons - metabolism Janus Kinase Inhibitors - therapeutic use Medical Biochemistry Mice Mice, Inbred C57BL Mice, Transgenic Molecular Medicine Piperidines - therapeutic use Pyrimidines - therapeutic use Pyrroles - therapeutic use Signal Transduction - drug effects Stem Cells Sulfonamides - therapeutic use Synovial Membrane - immunology Synovial Membrane - metabolism Synovial Membrane - pathology Synoviocytes - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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