Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells

The tight junctional pore-forming protein claudin-2 (CLDN-2) mediates paracellular Na+ and water transport in leaky epithelia and alters cancer cell proliferation. Previously, we reported that tumor necrosis factor-α time-dependently alters CLDN-2 expression in tubular epithelial cells. Here, we fou...

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Veröffentlicht in:	The Journal of biological chemistry 2019-10, Vol.294 (42), p.15446-15465
Hauptverfasser:	Dan, Qinghong, Shi, Yixuan, Rabani, Razieh, Venugopal, Shruthi, Xiao, Jenny, Anwer, Shaista, Ding, Mei, Speight, Pam, Pan, Wanling, Alexander, R. Todd, Kapus, András, Szászi, Katalin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Biology claudin Claudins - genetics Claudins - metabolism epithelial cell epithelial-mesenchymal transition (EMT) Female guanine nucleotide exchange factor (GEF) Humans Kidney Tubules - metabolism LLC-PK1 Cells Male Mice Mice, Inbred C57BL p27KIP1 Phenotype pro-fibrotic epithelial phenotype Ras homolog gene family, member A (RhoA) renal tubules Rho Guanine Nucleotide Exchange Factors - genetics Rho Guanine Nucleotide Exchange Factors - metabolism rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism small GTPase Swine tight junction Trans-Activators - genetics Trans-Activators - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Ureteral Obstruction - genetics Ureteral Obstruction - metabolism
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