Whole genome sequencing of drug resistant Mycobacterium tuberculosis isolates from a high burden tuberculosis region of North West Pakistan

Tuberculosis (TB), caused by Mycobacterium tuberculosis bacteria, is a leading infectious cause of mortality worldwide, including in Pakistan. Drug resistant M. tuberculosis is an emerging threat for TB control, making it important to detect the underlying genetic mutations, and thereby inform treat...

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Veröffentlicht in:	Scientific reports 2019-10, Vol.9 (1), p.14996-9, Article 14996
Hauptverfasser:	Jabbar, Abdul, Phelan, Jody E., de Sessions, Paola Florez, Khan, Taj Ali, Rahman, Hazir, Khan, Sadiq Noor, Cantillon, Daire M., Wildner, Leticia Muraro, Ali, Sajid, Campino, Susana, Waddell, Simon J., Clark, Taane G.
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/23 631/208/212/2304 631/208/325 Adolescent Adult Antitubercular Agents - therapeutic use Base Sequence Decision making Disease control Disease transmission DNA, Bacterial - genetics Drug resistance Drug Resistance, Multiple, Bacterial - genetics Epidemiology Ethambutol Ethionamide Female Fluoroquinolones Genomes Humanities and Social Sciences Humans Isoniazid Male Microbial Sensitivity Tests Middle Aged multidisciplinary Multidrug resistance Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Pakistan - epidemiology Phylogeny Polymorphism, Single Nucleotide Pyrazinamide Rifampin RpoB protein Science Science (multidisciplinary) Strains (organisms) Streptomycin Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - microbiology Tuberculosis, Multidrug-Resistant - transmission Whole Genome Sequencing - methods Young Adult
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