Towards Clinical Translation of CD8 + Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules

In central lymphoid tissues, mature lymphocytes are generated and pathogenic autoreactive lymphocytes are deleted. However, it is currently known that a significant number of potentially pathogenic autoreactive lymphocytes escape the deletion and populate peripheral lymphoid tissues. Therefore, peri...

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Veröffentlicht in:	International journal of molecular sciences 2019-09, Vol.20 (19), p.4829
Hauptverfasser:	Wasnik, Samiksha, Baylink, David J, Leavenworth, Jianmei, Liu, Chenfan, Bi, Hongzheng, Tang, Xiaolei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Clinical trials Cytotoxicity Epitopes - immunology Feedback Foxp3 protein Histocompatibility antigen HLA Histocompatibility Antigens Class I - immunology Humans Immune system Immune System Diseases - etiology Immune System Diseases - metabolism Immune System Diseases - therapy Immunomodulation Immunoregulation Lymphocytes Lymphocytes T Lymphoid tissue Major histocompatibility complex Peptides - immunology Review T cell receptors T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Translation Translational Research, Biomedical Vaccination
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