Regulation of oral immune tolerance by the microbiome in food allergy

•Food allergy (FA) is characterized by pathogenic dysbiosis.•The dysbiosis in FA disrupts oral tolerance to dietary antigens by impairing the generation of ROR-γt+ induced regulatory T cells.•Therapy with Clostridiales and Bacteroidales commensal bacteria activates a MyD88- ROR-γt axis in nascent iT...

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Veröffentlicht in:	Current opinion in immunology 2019-10, Vol.60, p.141-147
Hauptverfasser:	Stephen-Victor, Emmanuel, Chatila, Talal A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Susceptibility - immunology Dysbiosis - immunology Food Hypersensitivity - genetics Food Hypersensitivity - immunology Food Hypersensitivity - therapy Gene-Environment Interaction Genetic Predisposition to Disease Humans Immune Tolerance Immunomodulation Microbiota - immunology Precision Medicine T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism
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