The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus

Quinone compounds are electron carriers and have antimicrobial and toxic properties due to their mode of actions as electrophiles and oxidants. However, the regulatory mechanism of quinone resistance is less well understood in the pathogen . Methylhydroquinone (MHQ) caused a thiol-specific oxidative...

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Veröffentlicht in:	Antioxidants & redox signaling 2019-12, Vol.31 (16), p.1235-1252
Hauptverfasser:	Fritsch, Verena Nadin, Loi, Vu Van, Busche, Tobias, Sommer, Anna, Tedin, Karsten, Nürnberg, Dennis J, Kalinowski, Jörn, Bernhardt, Jörg, Fulde, Marcus, Antelmann, Haike
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Antiinfectives and antibacterials Antimicrobial agents Antimicrobial resistance Ciprofloxacin Deletion mutant Drug resistance Gene deletion Gene expression Homology Hypochlorous acid Infections Inverted repeat Macrophages Norfloxacin Original Research Communications Oxidants Oxidizing agents Penicillin Pyocyanin Quinones Reactive oxygen species Regulatory mechanisms (biology) Rifampin Staphylococcus aureus Staphylococcus infections Virulence
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