Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2

An increasing number of studies indicate that adrenergic signalling plays a fundamental role in chronic stress-induced tumour progression and metastasis. However, its function in gastric cancer (GC) and its potential mechanisms remain unknown. The expression levels of β-adrenergic receptor (ADRB) in...

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Veröffentlicht in:	Cell death & disease 2019-10, Vol.10 (11), p.788-15, Article 788
Hauptverfasser:	Zhang, Xuan, Zhang, Yi, He, Zhongyuan, Yin, Kai, Li, Bowen, Zhang, Lu, Xu, Zekuan
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/109 13/31 13/51 13/89 13/95 14 45 45/77 59 59/5 631/67/1504/1829 64 692/308/1426 82 82/1 82/29 82/51 82/80 96 96/2 96/31 Activator protein 1 Adrenergic receptors Animals Antibodies Apoptosis Atenolol Biochemistry Biomedical and Life Sciences Catecholamines Cell Biology Cell Culture Cell cycle Cell growth Cell migration Cell Movement - physiology Cell proliferation Cell Proliferation - physiology Cell viability Cortisol Cyclic AMP response element-binding protein Disease Progression Epinephrine Female Gastric cancer Gelatinase A Gelatinase B Heterografts Hormones Humans Immunology Life Sciences Male MAP Kinase Signaling System Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Neoplasm Metastasis NF-kappa B - metabolism Polymerase chain reaction Receptors, Adrenergic, beta-2 - biosynthesis Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics Signal Transduction STAT3 Transcription Factor - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stress, Physiological - physiology Transcription factors Tumors Vascular endothelial growth factor Xenografts
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