Caspase‐3‐mediated GSDME activation contributes to cisplatin‐ and doxorubicin‐induced secondary necrosis in mouse macrophages

Objective Induction of secondary necrosis/pyroptosis contributes to the toxicity of chemotherapeutic drugs, in which gasdermin E (GSDME) plays critical roles. This study aimed to explore whether GSDME is involved in mediating the cytotoxic effects of cisplatin and doxorubicin on mouse macrophages. M...

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Veröffentlicht in:	Cell proliferation 2019-09, Vol.52 (5), p.e12663-n/a
Hauptverfasser:	Mai, Feng‐Yi, He, Pengyan, Ye, Jie‐Zhou, Xu, Li‐Hui, Ouyang, Dong‐Yun, Li, Chen‐Guang, Zeng, Qiong‐Zhen, Zeng, Chen‐Ying, Zhang, Cheng‐Cheng, He, Xian‐Hui, Hu, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Animals Antibodies Apoptosis Apoptosis - drug effects Bacterial diseases Bacterial infections Biocompatibility Bone marrow Cancer therapies Caspase 3 - metabolism Caspase-3 Cells chemotherapeutic drugs Chemotherapy Cisplatin Cisplatin - pharmacology Cytokines - metabolism Cytotoxicity Depletion DNA damage Doxorubicin Doxorubicin - pharmacology Drugs Escherichia coli Infections - drug therapy Escherichia coli Infections - mortality Escherichia coli Infections - pathology Escherichia coli Infections - veterinary Experiments Flow cytometry gasdermin E Immunoblotting Immunofluorescence Infections Iodides Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Microscopy Necrosis Neurotoxicity Original Penicillin Peritoneum Phenotypes Propidium iodide Pyroptosis Pyroptosis - drug effects RAW 264.7 Cells Receptors, Estrogen - antagonists & inhibitors Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Ribose RNA Interference RNA, Small Interfering - metabolism secondary necrosis siRNA Software Statistical significance Survival Rate Toxicity Variance analysis
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