Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation

Type I interferon (IFN-I) production is efficiently induced to ensure a potent innate immune response to viral infection. How this response can be enhanced, however, remains to be explored. Here, we identify a new cytoplasmic long non-coding RNA (lncRNA), lncLrrc55-AS, that drives a positive feedbac...

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Veröffentlicht in:	Cell research 2019-08, Vol.29 (8), p.641-654
Hauptverfasser:	Zhou, Yumei, Li, Mengxuan, Xue, Yiquan, Li, Zhiqing, Wen, Weitao, Liu, Xingguang, Ma, Yuanwu, Zhang, Lianfeng, Shen, Zhongyang, Cao, Xuetao
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/21 13/89 14/19 38/71 38/77 631/250/262 631/337/384/2568 64/60 96/95 Animals Antiviral drugs Biomedical and Life Sciences Cell Biology Deactivation Demethylation Dogs Feedback loops Female HEK293 Cells Humans Immune response Immune system Immunity Immunity, Innate Inactivation Innate immunity Interferon Interferon regulatory factor Interferon regulatory factor 3 Interferon Regulatory Factor-3 - genetics Interferon Regulatory Factor-3 - metabolism Interferon Type I - immunology Interferon Type I - metabolism Life Sciences Madin Darby Canine Kidney Cells Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout NIH 3T3 Cells Non-coding RNA Phosphatase Phosphorylation Positive feedback RAW 264.7 Cells Rhabdoviridae Infections - immunology Rhabdoviridae Infections - virology RNA, Long Noncoding Signaling Vesicular stomatitis Indiana virus - immunology Viruses
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