P14.29 Prediction of overall survival in patients with malignant glioma using dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine PET

P14.29 Prediction of overall survival in patients with malignant glioma using dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine PET

Abstract BACKGROUND Characterization of gliomas according to the revised World Health Organization (WHO) classification of 2016 has gained major importance regarding prognostication. The present study aimed at exploring the prognostic value of dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) PET in...

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Veröffentlicht in:Neuro-oncology (Charlottesville, Va.) Va.), 2019-09, Vol.21 (Supplement_3), p.iii73-iii73
Hauptverfasser: Bauer, E K, Stoffels, G, Blau, T, Reifenberger, G, Werner, J M, Lohmann, P, Rapp, M, Fink, G R, Langen, K, Galldiks, N
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container_issue Supplement_3
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container_title Neuro-oncology (Charlottesville, Va.)
container_volume 21
creator Bauer, E K
Stoffels, G
Blau, T
Reifenberger, G
Werner, J M
Lohmann, P
Rapp, M
Fink, G R
Langen, K
Galldiks, N
description Abstract BACKGROUND Characterization of gliomas according to the revised World Health Organization (WHO) classification of 2016 has gained major importance regarding prognostication. The present study aimed at exploring the prognostic value of dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) PET in newly diagnosed and molecularly defined astrocytic high-grade glioma (HGG) of the WHO grades III or IV. MATERIAL AND METHODS Before initiation of treatment, dynamic FET PET imaging was performed in patients with newly diagnosed glioblastoma (GBM) and anaplastic astrocytoma (AA). Static FET PET parameters such as maximum and mean tumor/brain ratios (TBRmax/mean), as well as the dynamic FET PET parameters time-to-peak (TTP) and slope, were obtained. The predictive ability of FET PET parameters was evaluated with regard to the overall survival (OS). Using ROC analyses, threshold values for FET PET parameters were obtained. Subsequently, univariate Kaplan-Meier and multivariate Cox regression survival analyses were performed to assess their predictive power for OS. RESULTS Sixty patients (45 GBM, 15 AA) of two university centers were retrospectively identified. Patients with a methylated MGMT promoter as well as with an IDH mutation had a significantly longer OS (both P25 minutes (AUC, 0.90; sensitivity, 90%; specificity, 87%; P
doi_str_mv 10.1093/neuonc/noz126.264
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The present study aimed at exploring the prognostic value of dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) PET in newly diagnosed and molecularly defined astrocytic high-grade glioma (HGG) of the WHO grades III or IV. MATERIAL AND METHODS Before initiation of treatment, dynamic FET PET imaging was performed in patients with newly diagnosed glioblastoma (GBM) and anaplastic astrocytoma (AA). Static FET PET parameters such as maximum and mean tumor/brain ratios (TBRmax/mean), as well as the dynamic FET PET parameters time-to-peak (TTP) and slope, were obtained. The predictive ability of FET PET parameters was evaluated with regard to the overall survival (OS). Using ROC analyses, threshold values for FET PET parameters were obtained. Subsequently, univariate Kaplan-Meier and multivariate Cox regression survival analyses were performed to assess their predictive power for OS. RESULTS Sixty patients (45 GBM, 15 AA) of two university centers were retrospectively identified. Patients with a methylated MGMT promoter as well as with an IDH mutation had a significantly longer OS (both P&lt;0.001). Furthermore, ROC analysis revealed in IDH-wildtype HGG (n=45) that a TTP&gt;25 minutes (AUC, 0.90; sensitivity, 90%; specificity, 87%; P&lt;0.001) was highly prognostic for a longer OS (29 vs. 12 months; P&lt;0.001). Besides a complete resection and a methylated MGMT promoter, TTP remained significant in the multivariate survival analysis (P=0.002, P=0.016, and P=0.003, respectively), indicating an independent predictor for OS. In contrast, both TBRmax and TBRmean were not prognostic (AUC, 0.37 and 0.32, respectively). CONCLUSION Data suggest that within the subgroup of patients with newly diagnosed and untreated IDH-wildtype GBM and AA, dynamic FET PET additionally allows the identification of patients with an improved OS.</description><identifier>ISSN: 1522-8517</identifier><identifier>EISSN: 1523-5866</identifier><identifier>DOI: 10.1093/neuonc/noz126.264</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Poster Presentations</subject><ispartof>Neuro-oncology (Charlottesville, Va.), 2019-09, Vol.21 (Supplement_3), p.iii73-iii73</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795938/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795938/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,887,1586,27931,27932,53798,53800</link.rule.ids></links><search><creatorcontrib>Bauer, E K</creatorcontrib><creatorcontrib>Stoffels, G</creatorcontrib><creatorcontrib>Blau, T</creatorcontrib><creatorcontrib>Reifenberger, G</creatorcontrib><creatorcontrib>Werner, J M</creatorcontrib><creatorcontrib>Lohmann, P</creatorcontrib><creatorcontrib>Rapp, M</creatorcontrib><creatorcontrib>Fink, G R</creatorcontrib><creatorcontrib>Langen, K</creatorcontrib><creatorcontrib>Galldiks, N</creatorcontrib><title>P14.29 Prediction of overall survival in patients with malignant glioma using dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine PET</title><title>Neuro-oncology (Charlottesville, Va.)</title><description>Abstract BACKGROUND Characterization of gliomas according to the revised World Health Organization (WHO) classification of 2016 has gained major importance regarding prognostication. The present study aimed at exploring the prognostic value of dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) PET in newly diagnosed and molecularly defined astrocytic high-grade glioma (HGG) of the WHO grades III or IV. MATERIAL AND METHODS Before initiation of treatment, dynamic FET PET imaging was performed in patients with newly diagnosed glioblastoma (GBM) and anaplastic astrocytoma (AA). Static FET PET parameters such as maximum and mean tumor/brain ratios (TBRmax/mean), as well as the dynamic FET PET parameters time-to-peak (TTP) and slope, were obtained. The predictive ability of FET PET parameters was evaluated with regard to the overall survival (OS). Using ROC analyses, threshold values for FET PET parameters were obtained. Subsequently, univariate Kaplan-Meier and multivariate Cox regression survival analyses were performed to assess their predictive power for OS. RESULTS Sixty patients (45 GBM, 15 AA) of two university centers were retrospectively identified. Patients with a methylated MGMT promoter as well as with an IDH mutation had a significantly longer OS (both P&lt;0.001). Furthermore, ROC analysis revealed in IDH-wildtype HGG (n=45) that a TTP&gt;25 minutes (AUC, 0.90; sensitivity, 90%; specificity, 87%; P&lt;0.001) was highly prognostic for a longer OS (29 vs. 12 months; P&lt;0.001). Besides a complete resection and a methylated MGMT promoter, TTP remained significant in the multivariate survival analysis (P=0.002, P=0.016, and P=0.003, respectively), indicating an independent predictor for OS. In contrast, both TBRmax and TBRmean were not prognostic (AUC, 0.37 and 0.32, respectively). CONCLUSION Data suggest that within the subgroup of patients with newly diagnosed and untreated IDH-wildtype GBM and AA, dynamic FET PET additionally allows the identification of patients with an improved OS.</description><subject>Poster Presentations</subject><issn>1522-8517</issn><issn>1523-5866</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNkF9LwzAUxYsoOKcfwLc8KpitaZM0eRFkbCoMtof5JBLSNOkibTL6Typ-eKsVwTef7oV7zuGeXxBconCGQh7PnW69U3Pn31FEZxHFR8EEkSiGhFF6_L1HkBGUnAZndf0ahhEiFE2Cjy3Cs4iDbaUzqxrrHfAG-E5XsihA3Vad7WQBrAMH2Vjtmhq82WYPSlnY3EnXgLywvpSgra3LQdY7WVoFNvAqgs-IrV6gKVpfed3s--IarmHTV36QarBd7s6DEyOLWl_8zGnwtFruFg9wvbl_XNytoUJJgiEnCjOO0jgmxiiGFQ4jGXIZY6QTzo3ODCE6Q0xrgzlNJUMspiQ1WLJUhzSeBrdj7qFNS52pocZQTxwqW8qqF15a8ffi7F7kvhM04YTHbAhAY4Aanq8rbX69KBRf_MXIX4z8xcB_8NyMHt8e_iH_BOZLjPo</recordid><startdate>20190906</startdate><enddate>20190906</enddate><creator>Bauer, E K</creator><creator>Stoffels, G</creator><creator>Blau, T</creator><creator>Reifenberger, G</creator><creator>Werner, J M</creator><creator>Lohmann, P</creator><creator>Rapp, M</creator><creator>Fink, G R</creator><creator>Langen, K</creator><creator>Galldiks, N</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20190906</creationdate><title>P14.29 Prediction of overall survival in patients with malignant glioma using dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine PET</title><author>Bauer, E K ; Stoffels, G ; Blau, T ; Reifenberger, G ; Werner, J M ; Lohmann, P ; Rapp, M ; Fink, G R ; Langen, K ; Galldiks, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1774-95c4891b335ffc84c402a09a341e799fedf55ed18eef496ba818365bf4a8be063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Poster Presentations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bauer, E K</creatorcontrib><creatorcontrib>Stoffels, G</creatorcontrib><creatorcontrib>Blau, T</creatorcontrib><creatorcontrib>Reifenberger, G</creatorcontrib><creatorcontrib>Werner, J M</creatorcontrib><creatorcontrib>Lohmann, P</creatorcontrib><creatorcontrib>Rapp, M</creatorcontrib><creatorcontrib>Fink, G R</creatorcontrib><creatorcontrib>Langen, K</creatorcontrib><creatorcontrib>Galldiks, N</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bauer, E K</au><au>Stoffels, G</au><au>Blau, T</au><au>Reifenberger, G</au><au>Werner, J M</au><au>Lohmann, P</au><au>Rapp, M</au><au>Fink, G R</au><au>Langen, K</au><au>Galldiks, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P14.29 Prediction of overall survival in patients with malignant glioma using dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine PET</atitle><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle><date>2019-09-06</date><risdate>2019</risdate><volume>21</volume><issue>Supplement_3</issue><spage>iii73</spage><epage>iii73</epage><pages>iii73-iii73</pages><issn>1522-8517</issn><eissn>1523-5866</eissn><abstract>Abstract BACKGROUND Characterization of gliomas according to the revised World Health Organization (WHO) classification of 2016 has gained major importance regarding prognostication. The present study aimed at exploring the prognostic value of dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) PET in newly diagnosed and molecularly defined astrocytic high-grade glioma (HGG) of the WHO grades III or IV. MATERIAL AND METHODS Before initiation of treatment, dynamic FET PET imaging was performed in patients with newly diagnosed glioblastoma (GBM) and anaplastic astrocytoma (AA). Static FET PET parameters such as maximum and mean tumor/brain ratios (TBRmax/mean), as well as the dynamic FET PET parameters time-to-peak (TTP) and slope, were obtained. The predictive ability of FET PET parameters was evaluated with regard to the overall survival (OS). Using ROC analyses, threshold values for FET PET parameters were obtained. Subsequently, univariate Kaplan-Meier and multivariate Cox regression survival analyses were performed to assess their predictive power for OS. RESULTS Sixty patients (45 GBM, 15 AA) of two university centers were retrospectively identified. Patients with a methylated MGMT promoter as well as with an IDH mutation had a significantly longer OS (both P&lt;0.001). Furthermore, ROC analysis revealed in IDH-wildtype HGG (n=45) that a TTP&gt;25 minutes (AUC, 0.90; sensitivity, 90%; specificity, 87%; P&lt;0.001) was highly prognostic for a longer OS (29 vs. 12 months; P&lt;0.001). Besides a complete resection and a methylated MGMT promoter, TTP remained significant in the multivariate survival analysis (P=0.002, P=0.016, and P=0.003, respectively), indicating an independent predictor for OS. In contrast, both TBRmax and TBRmean were not prognostic (AUC, 0.37 and 0.32, respectively). CONCLUSION Data suggest that within the subgroup of patients with newly diagnosed and untreated IDH-wildtype GBM and AA, dynamic FET PET additionally allows the identification of patients with an improved OS.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/neuonc/noz126.264</doi><oa>free_for_read</oa></addata></record>
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title P14.29 Prediction of overall survival in patients with malignant glioma using dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine PET
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