IFNL3 genotype is associated with pulmonary fibrosis in patients with systemic sclerosis

Fibrosis across different organs and tissues is likely to share common pathophysiological mechanisms and pathways. Recently, a polymorphism (rs12979860) near the interferon lambda gene ( IFNL3 ) was shown to be associated with fibrosis in liver across multiple disease etiologies. We determined wheth...

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Veröffentlicht in:	Scientific reports 2019-10, Vol.9 (1), p.14834-5, Article 14834
Hauptverfasser:	Metwally, Mayada, Thabet, Khaled, Bayoumi, Ali, Nikpour, Mandana, Stevens, Wendy, Sahhar, Joanne, Zochling, Jane, Roddy, Janet, Tymms, Kathleen, Strickland, Gemma, Lester, Susan, Rischmueller, Maureen, Ngian, Gene-Siew, Walker, Jennifer, Hissaria, Pravin, Shaker, Olfat, Liddle, Christopher, Manolios, Nicholas, Beretta, Lorenzo, Proudman, Susanna, George, Jacob, Eslam, Mohammed
Format:	Artikel
Sprache:	eng
Schlagworte:	42/41 45/22 45/90 64/60 692/308/2056 692/308/575 Aged Female Fibrosis Gene polymorphism Genetic diversity Genetic Predisposition to Disease Genetic variance Humanities and Social Sciences Humans Interferon Interferons - blood Interferons - genetics Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver diseases Lung diseases Male Middle Aged multidisciplinary Polymorphism Polymorphism, Single Nucleotide Pulmonary fibrosis Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Risk factors Science Science (multidisciplinary) Scleroderma Scleroderma, Systemic - genetics Scleroderma, Systemic - metabolism Serum levels Skin Skin - pathology Systemic sclerosis
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