ROR1-CAR T-cells are effective against lung and breast cancer in advanced microphysiologic 3D tumor models

Solid tumors impose immunological and physical barriers to the efficacy of chimeric antigen receptor (CAR) T-cell therapy that are not reflected in conventional pre-clinical testing against singularized tumor cells in two-dimensional culture. Here, we established microphysiologic three-dimensional (...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	JCI insight 2019-09, Vol.4 (18)
Hauptverfasser:	Wallstabe, Lars, Göttlich, Claudia, Nelke, Lena C, Kühnemundt, Johanna, Schwarz, Thomas, Nerreter, Thomas, Einsele, Hermann, Walles, Heike, Dandekar, Gudrun, Nietzer, Sarah L, Hudecek, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Technical Advance
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!