Lipid Binding Regulates Synaptic Targeting of PICK1, AMPA Receptor Trafficking, and Synaptic Plasticity

The targeting and surface expression of membrane proteins are critical to their functions. In neurons, synaptic targeting and surface expression of AMPA-type glutamate receptors were found to be critical for synaptic plasticity such as long-term potentiation and long-term depression (LTD). PICK1 (pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2006-03, Vol.26 (9), p.2380-2390
Hauptverfasser:	Jin, Wenying, Ge, Woo-Ping, Xu, Junyu, Cao, Mian, Peng, Lisheng, Yung, Wingho, Liao, Dezhi, Duan, Shumin, Zhang, Mingjie, Xia, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biotinylation - methods Blotting, Western - methods Carrier Proteins - genetics Carrier Proteins - metabolism Cells, Cultured Cercopithecus aethiops Cloning, Molecular - methods Disks Large Homolog 4 Protein Dose-Response Relationship, Drug Electric Stimulation - methods Embryo, Mammalian Green Fluorescent Proteins - metabolism Hippocampus - cytology Humans Immunoprecipitation - methods In Vitro Techniques Intracellular Signaling Peptides and Proteins - metabolism Lipids - physiology Long-Term Synaptic Depression - physiology Long-Term Synaptic Depression - radiation effects Membrane Proteins - metabolism Models, Biological Mutation Neuronal Plasticity - physiology Neurons - physiology Nuclear Proteins - genetics Nuclear Proteins - metabolism Patch-Clamp Techniques - methods Phosphatidylinositols - pharmacokinetics Protein Binding Protein Structure, Tertiary - physiology Protein Transport - physiology Rats Receptors, AMPA - metabolism Subcellular Fractions - drug effects Subcellular Fractions - physiology Transfection - methods Two-Hybrid System Techniques
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!